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Monday, April 28, 2014

Herbal Huang Qi. and Skin Aging

Posted by Chantel Martiromo 

Skin aging is one of most visible process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin,  affected skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading  injuries damage regulation pathways of skin,  including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
The degradation of the epidermal and dermal layers of the extracellular matrix (ECM), the non-cellular component present within all tissues and organs, such as UV Exposure, decline of lysosomal/endosomal cathepsin K, S and V activity(c) as well as some environmental factors on skin produces visible signs such as irregular dryness, dark/light pigmentation, sallowness, severe atrophy, telangiectases, premalignant lesions, laxity, leathery appearance and deep wrinkling, etc.,  cause modification of the surface of skin and the physical properties of that lead to skin aging.
Certain chemical ingredients, such as aloin, ginsenoside, curcumin, epicatechin, asiaticoside, ziyuglycoside I, magnolol, gallic acid, hydroxychavicol, hydroxycinnamic acids, hydroxybenzoic acids, etc.  derived from herbs have been found to be intergraded  into some cosmetic products in treating premature aging(d).
Huang Qi (Radix astragali) 
Huang Qi or Bei Qi is also known as Astragalus root. The sweet herb
 has been used as diuretic agent and to lower blood pressure, increase blood pressure, lessens
proteinuria, improve endurance, protect liver function, regulate blood sugar, etc. as it tonifies Qi,
raises Yang, strengthens the Defensive-Qi and the Exterior, expels toxins, etc. by enhancing the
functions of lung and spleen channels.
The study of non-fermented (HQNB) and fermented preparations (HQB) of Radix astragali on
hyaluronic acid (HA) production in primary human skin cells, showed that HQB significantly
stimulated HA production in both cultured primary human epidermal keratinocytes and human dermal
fibroblasts and  increased the expression of hyaluronan synthase 3 and hyaluronan synthase 2 mRNA
in HaCaT cells and human fibroblasts, respectively in dose-dependent manners(42)
.
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References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(c) Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis by Sage J1, De Quéral D2, Leblanc-Noblesse E2, Kurfurst R2, Schnebert S2, Perrier E2, Nizard C2, Lalmanach G3, Lecaille F4.(PubMed)
(d) Bioactive compounds from natural resources against skin aging by Mukherjee PK1, Maity N, Nema NK, Sarkar BK.(PubMed)

(41) Biochemical Composition and Antioxidant Properties of Lavandula angustifolia Miller Essential Oil are Shielded by Propolis Against UV Radiations by Angelo G1, Lorena C, Marta G, Antonella C.(PubMed)
(42) Stimulating effects of Bacillus subtilis natto-fermented Radix astragali on hyaluronic acid production in human skin cells by Hsu MF1, Chiang BH.(PubMed)

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