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Saturday, April 5, 2014

Ovarian Cancer and Devil's Club

  Posted by Chantel Martiromo

Ovarian cancer is defined as a condition of  abnormal ovarian cells growth of ovaries.  It is one of most common cancer in US, according to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, an estimated 21,880 women in the United States will be diagnosed with ovarian cancer and 13,850 deaths.
Devil's Club is a large shrub, genus Oplopanax, belonging to the family Aralioideae, native to the cool moist forests of western North America. The herb has been used in traditional and herbal medicine as Adaptogen, Antipyretic, Pain Reliever, Antitussive, Antibacterial agent and to treat Arthritis, Diabetes, Colds, Cough, Sore throat, Chest congestion, Stomach pain, Constipation, Gall stones, Influenza, Cancer, etc.
Ethanolic extract of Devil club dry root bark powder, showed to inhibit the proliferation of some cancer cell lines including K562, HL60, MCF7 and MDA-MB-468 cell growth with the 50% inhibition (IC(50))(22). Water, 70% ethanol, 100% ethanol, and ethyl acetate extracts of OH exhibited significant anti-proliferation effect against both cisplatin sensitive and resistant human ovarian cell lines, including human ovarian cancer cell lines A2780, A2780CP70, OVCAR3, and OVCAR10, according the University of British Columbia(23). In comparison with stem and berry, researchers found that stem extract after administration of 72 h, increased cells apoptosis cells through cell cycle arrest and induction of apoptosis on different human cancer cell lines (SW-480, HCT-116, HT-29, MCF-7 and NSCLC)(24).
 
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References   

(22) In vitro anti-proliferative and antioxidant studies on Devil's Club Oplopanax horridus by Tai J1, Cheung S, Cheah S, Chan E, Hasman D.(PubMed)
(23) Inhibition of human ovarian cancer cell lines by devil's club Oplopanax horridus by Tai J1, Cheung S, Chan E, Hasman D.(PubMed)
(24) High performance liquid chromatographic analysis and anticancer potential of Oplopanax horridus: comparison of stem and berry extracts by Wang CZ1, Aung HH, Mehendale SR, Shoyama Y, Yuan CS.(PubMed

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