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Friday, April 25, 2014

Herbal Rosemary and Skin Aging

Posted by Chantel Martiromo 

Skin aging is one of most visible process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin,  affected skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading  injuries damage regulation pathways of skin,  including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
The degradation of the epidermal and dermal layers of the extracellular matrix (ECM), the non-cellular component present within all tissues and organs, such as UV Exposure, decline of lysosomal/endosomal cathepsin K, S and V activity(c) as well as some environmental factors on skin produces visible signs such as irregular dryness, dark/light pigmentation, sallowness, severe atrophy, telangiectases, premalignant lesions, laxity, leathery appearance and deep wrinkling, etc.,  cause modification of the surface of skin and the physical properties of that lead to skin aging.
Certain chemical ingredients, such as aloin, ginsenoside, curcumin, epicatechin, asiaticoside, ziyuglycoside I, magnolol, gallic acid, hydroxychavicol, hydroxycinnamic acids, hydroxybenzoic acids, etc.  derived from herbs have been found to be intergraded  into some cosmetic products in treating premature aging(d).

Rosemary is a perennial herb with fragrant, evergreen, needle-like leaves, the genus 
Rosmarinus,
belonging to the family Lamiaceae. Its fresh and dried leaves has been used frequently in traditional
Mediterranean cuisine and as flavor foods while barbecuing. Rosnary has been used in traditional
medicine as an antiseptic, antioxidant, and antispasmodic agent to treat circulatory problem, eczema,
rheumatism, muscle pain, etc.
Rosemary containing flavonoid compounds with phenolic structures may potentiate in reduced reactive
oxygen species and biologic macromolecules, to neutralize free radicals or initiate biological effects to
prevent skin damage(35). According to University of Catania, natural extract isolated from rosemary
leaves, showed to be effective in antiaging skin management due to its endogenous antioxidant
potential(36).


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References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(c) Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis by Sage J1, De Quéral D2, Leblanc-Noblesse E2, Kurfurst R2, Schnebert S2, Perrier E2, Nizard C2, Lalmanach G3, Lecaille F4.(PubMed)
(d) Bioactive compounds from natural resources against skin aging by Mukherjee PK1, Maity N, Nema NK, Sarkar BK.(PubMed)
(35) Green tea and the skin by Hsu S.(PubMed)
(36) Biochemical studies of a natural antioxidant isolated from rosemary and its application in cosmetic dermatology by Calabrese V1, Scapagnini G, Catalano C, Dinotta F, Geraci D, Morganti P.
(PubMed)

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