Posted by Chantel Martiromo
Skin aging is one of most visible process which occurs constantly
in our skin organ. According to the Clinical Centre of Nis, certain
plant extracts may have the ability to scavenge free radicals, to
protect the skin matrix through the inhibition of enzymatic degradation,
or to promote collagen synthesis in the skin, affected skin elasticity
and tightness(a). Other suggested that free radicals induced domino
effects in production of reactive oxygen species, can react with DNA,
proteins, and fatty acids, causing oxidative damage and impairment of
antioxidant system, leading injuries damage regulation pathways of
skin, including wrinkles, roughness, appearance of fine lines, lack of
elasticity, and de- or hyperpigmentation marks(b).
The degradation of the epidermal and dermal layers of the extracellular
matrix (ECM), the non-cellular component present within all tissues and
organs, such as UV Exposure, decline of lysosomal/endosomal cathepsin K,
S and V activity(c) as well as some environmental factors on skin
produces visible signs such as irregular dryness, dark/light
pigmentation, sallowness, severe atrophy, telangiectases, premalignant
lesions, laxity, leathery appearance and deep wrinkling, etc., cause
modification of the surface of skin and the physical properties of that lead to skin aging.
Certain chemical ingredients, such as aloin,
ginsenoside, curcumin, epicatechin, asiaticoside, ziyuglycoside I,
magnolol, gallic acid, hydroxychavicol, hydroxycinnamic acids,
hydroxybenzoic acids, etc. derived from herbs have been found to be
intergraded into some cosmetic products in treating premature aging(d).
Grape Seed Extract is the commercial extracts from whole grape seeds that contains many
concentrations, including vitamin E, flavonoids, linoleic acid, oligomeric proanthocyanidins(OPCs),
etc..The herb has been used in traditional medicine as antioxidant, anti-inflammatory agents and to treat
skin wounds with less scarring, allergies, macular degeneration, arthritis, enhance circulation of blood
vessels, lower cholesterol, etc.
Grape seed extract may be beneficial in promoting youthful skin, cell health, elasticity, and flexibility
because of its antioxidant effect to bond with collagen(37).
According to Dr. Bojanowski K., grape seed extract may have a potential in anti-aging effects
throughout all skin compartments, including dermal and epidermal layers because of its induced signal
transduction pathways in facial hypodermis(38). In a study of a total of men from 35 to 60 years of age,
phototypes I to III, indictaed a positive effect in counteract skin photoaging, in daily application of
mixture containing lycopene, acerola extract, grape seed extract and Biomarine ComplexT(39).
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(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(c) Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis by Sage J1, De Quéral D2, Leblanc-Noblesse E2, Kurfurst R2, Schnebert S2, Perrier E2, Nizard C2, Lalmanach G3, Lecaille F4.(PubMed)
(d) Bioactive compounds from natural resources against skin aging by Mukherjee PK1, Maity N, Nema NK, Sarkar BK.(PubMed)
(37) enolics in grape seeds-biochemistry and functionality by Shi J1, Yu J, Pohorly JE, Kakuda Y.by (PubMed)
(38) Hypodermal delivery of cosmetic actives for improved facial skin morphology and functionality by Bojanowski K.(PubMed)
(39)Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and Biomarine Complex in photoaged human skin by Costa A1, Lindmark L, Arruda LH, Assumpção EC, Ota FS, Pereira Mde O, Langen SS.(PubMed)
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