Posted by Chantel Martiromo
Ovarian cancer is defined as
a condition of abnormal ovarian cells growth of ovaries. It is
one of most common cancer in US, according to the statistics adapted
from the American Cancer Society's publication, Cancer Facts &
Figures 2010, an estimated 21,880 women in the United States will be
diagnosed with ovarian cancer and 13,850 deaths.
Cranberry is a evergreen dwarf shrubs, genus
Vaccinium, belonging to the family Ericaceae, native to Northern
America and Southern Asia. Because of health benefits, it has been
cultivated in some parts of the world forcommercial profits and used in
traditional and herbal medicine to treat wounds,urinary disorders,
diarrhea, diabetes, stomach ailments, and liver problems.
Proanthocyanidin (PAC)-rich isolate from cranberry
(PAC-1), inhibited ovarian cancer SKOV-3 cell line through blocked cell
cycle progression through the G2/M phase, increased the
generation of reactive oxygen species (ROS), and induced
apoptosis through activation of intrinsic and extrinsic pathway
components(18). Treatment with Proanthocyanidin in SKOV-3 ovarian cancer
cells exhibited classic apoptotic changesnd pretreatment of SKOV-3
cells with PACs (106 microg/ml) resulted in a significant reduction of
the paraplatin IC50 value(19).
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References
(18) Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells by Kim KK1, Singh AP, Singh RK, Demartino A, Brard L, Vorsa N, Lange TS, Moore RG.(PubMed)
(19) Cranberry proanthocyanidins are cytotoxic to human cancer cells and sensitize platinum-resistant ovarian cancer cells to paraplatin by Singh AP1, Singh RK, Kim KK, Satyan KS, Nussbaum R, Torres M, Brard L, Vorsa N.(PubMed)
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".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.
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