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Thursday, April 3, 2014

Ovarian Cancer and Herbal Cranberry

  Posted by Chantel Martiromo

Ovarian cancer is defined as a condition of  abnormal ovarian cells growth of ovaries.  It is one of most common cancer in US, according to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, an estimated 21,880 women in the United States will be diagnosed with ovarian cancer and 13,850 deaths.

Cranberry is a evergreen dwarf shrubs, genus Vaccinium, belonging to the family  Ericaceae, native to Northern America and Southern Asia. Because of health benefits, it has been cultivated in some parts of the world forcommercial profits and used in traditional and herbal medicine to treat wounds,urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
Proanthocyanidin (PAC)-rich isolate from cranberry (PAC-1), inhibited ovarian cancer SKOV-3 cell line through blocked cell cycle progression through the G2/M phase, increased the generation of reactive oxygen species (ROS), and induced apoptosis through activation of intrinsic and extrinsic pathway components(18). Treatment with Proanthocyanidin in SKOV-3 ovarian cancer cells  exhibited classic apoptotic changesnd pretreatment of SKOV-3 cells with PACs (106 microg/ml) resulted in a significant reduction of the paraplatin IC50 value(19).
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References  

(18) Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells by Kim KK1, Singh AP, Singh RK, Demartino A, Brard L, Vorsa N, Lange TS, Moore RG.(PubMed)
(19) Cranberry proanthocyanidins are cytotoxic to human cancer cells and sensitize platinum-resistant ovarian cancer cells to paraplatin by Singh AP1, Singh RK, Kim KK, Satyan KS, Nussbaum R, Torres M, Brard L, Vorsa N.(PubMed
 

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