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Friday, April 18, 2014

Herbal Aloe vera and Skin Aging

  Posted by Chantel Martiromo 

Skin aging is one of most visible process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin,  affected skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading  injuries damage regulation pathways of skin,  including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
The degradation of the epidermal and dermal layers of the extracellular matrix (ECM), the non-cellular component present within all tissues and organs, such as UV Exposure, decline of lysosomal/endosomal cathepsin K, S and V activity(c) as well as some environmental factors on skin produces visible signs such as irregular dryness, dark/light pigmentation, sallowness, severe atrophy, telangiectases, premalignant lesions, laxity, leathery appearance and deep wrinkling, etc.,  cause modification of the surface of skin and the physical properties of that lead to skin aging.
Certain chemical ingredients, such as aloin, ginsenoside, curcumin, epicatechin, asiaticoside, ziyuglycoside I, magnolol, gallic acid, hydroxychavicol, hydroxycinnamic acids, hydroxybenzoic acids, etc.  derived from herbs have been found to be intergraded  into some cosmetic products in treating premature aging(d)
Aloe vera
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herb studied in scientific ways with some conflicted results.
In a study of a total of 30 healthy female subjects over the age of 45 recruited and received 2 different doses (low-dose: 1,200 mg/d, high-dose: 3,600 mg/d) of aloe vera gel supplementation for 90 days, aloe gel significantly improved wrinkles and elasticity in photoaged human skin, with an increase in collagen production in the photoprotected skin and a decrease in the collagen-degrading MMP-1 gene expression(1). In skin condition in the elderly caused by several incurable, but treatable, chronic diseases, researchers suggested that the use of lanolin, aloe vera, and parabens may contribute to  delayed hypersensitivity reaction and aging process(2). In photo aging, combination of sodium selenite and aloin in a certain range of concentration have shown protective effects against ultraviolet radiation induced fibroblast proliferation inhibition, oxidative injury, and decreased collagen synthesis(3).

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References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(c) Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis by Sage J1, De Quéral D2, Leblanc-Noblesse E2, Kurfurst R2, Schnebert S2, Perrier E2, Nizard C2, Lalmanach G3, Lecaille F4.(PubMed)
(d) Bioactive compounds from natural resources against skin aging by Mukherjee PK1, Maity N, Nema NK, Sarkar BK.(PubMed)
(1) Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo by Cho S1, Lee S, Lee MJ, Lee DH, Won CH, Kim SM, Chung JH.(PubMed)
(2) Dry skin in the elderly: complexities of a common problem by White-Chu EF1, Reddy M.(PubMed)
(3) [The protective effects of sodium selenite and aloin against ultraviolet A radiation].

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