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Monday, April 11, 2016

The Smoothie of Reishi mushroom and Cooked Artichokes for Prevention and Treatment of Primary Biliary Cirrhosis

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  Primary Biliary Cirrhosis
Yield: 2 servings (about 8 ounces each)
1 1/2 cups of cooked artichokes
1 cup Reishi mushroom tea (Make from t tea bags of Reishi mushroom tea and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Primary Biliary Cirrhosiss has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Primary Biliary Cirrhosis is a condition of slowly destroyed of bile dusts, causing damage to liver as a result of bile building up. Antioxidant therapy is found effectively in improvement of the pruritus and fatigue of PBC(1).

Recent studies back by well known institutions proposed, Reishi mushroom and Cooked Artichokes may be the next generation of natural ingredients for prevention and treatment of Primary Biliary Cirrhosis.

According to the China Medical University, glycyrrhizin, silymarin, and ursodeoxycholic acid may have potential for prevention and treatment of primary biliary cirrhosis due to antioxidants effect in regulated the expression of genes relevant to apoptosis and oxidative stress in HepG2 cells(2).

Glycyrrhizin, found abundantly in Reishi mushroom or Lingzhi is a fungal species in the genus Ganoderma, belongings to the family Ganodermataceae, native to Asia. According to the Wonkwang University, has an antifibrotic effect on fibrotic rats induced by a bile duct ligation and scission (BDL/S)(3).

Silymarin, an antioxidant found in milk thistle and cooked artichokes may also be important ingredient for prevention and treatment of Primary Biliary Cirrhosis(2). According to the joint study led by the University of Foggia, silybin exerted antioxidant effects against accumulation of toxic hydrophobic bile acids in hepatocytes,caused by chronic cholestasis, through inhibition of mitochondrial failure in rat with secondary biliarycirrhosis(4).
Dr. Matveev AV and colleagues in the study of liver protective effects of silymarin ssaid," clinical trials and systematic reviews of silymarin use show high efficacy of the drug in patients with amanitine, drugs, and other toxic injuries of liver, viral hepatitis, NASH. In patients with carcinoma and primarily biliary cirrhosis efficacy of silymarin is ambiguous"(5).

The effectiveness of Reishi mushroom and Cooked Artichokes may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Primary Biliary Cirrhosis with little or no adverse effects.

People who are at high risk of Primary Biliary Cirrhosis due to family history, environment factors, .... should drink at least one serving daily and women with Primary Biliary Cirrhosis should drink the smoothie as much as they can, depending to digestive toleration.

Life style and dietary pattern(reduced intake of  bad cholesterol)change are recommended.

(1) Case report: oral antioxidant therapy for the treatment of primary biliary cirrhosis: a pilot study by Watson JP1, Jones DE, James OF, Cann PA, Bramble MG.(PubMed)
(2) Glycyrrhizin, silymarin, and ursodeoxycholic acid regulate a common hepatoprotective pathway in HepG2 cells by Hsiang CY1, Lin LJ2, Kao ST2, Lo HY3, Chou ST3, Ho TY4.(PubMed)
(3) Antifibrotic effects of a polysaccharide extracted from Ganoderma lucidum, glycyrrhizin, and pentoxifylline in rats with cirrhosis induced by biliary obstruction by Park EJ1, Ko G, Kim J, Sohn DH.(PubMed)
(4) Silybin exerts antioxidant effects and induces mitochondrial biogenesis in liver of rat with secondary biliarycirrhosis by Serviddio G1, Bellanti F1, Stanca E2, Lunetti P2, Blonda M1, Tamborra R1, Siculella L2, Vendemiale G1, Capobianco L3, Giudetti AM4.(PubMed)
(5) [Hepatoprotective properties of silymarin].[Article in Russian] by Matveev AV, Koniaeva EI, Kurchenko VP, Shchekatikhina AS.(PubMed)

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