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Monday, April 25, 2016

The Tasty and Delicious Smoothie of Green Tea, Coffee and Grape for Reduced Risk and Treatment of Renal Cell Carcinoma

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of  Kidney Cancer (Renal Cell Carcinoma)
Yield: 2 serving (about 8 ounce each)
1/2 cup grape
3/4 cup regular coffee
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Renal cell carcinoma is a type of kidney cancer caused by malignant cells of the limning of the tubules in the kidney. It tends first to spread via bloodstream and the second tumor generally found in the lung, but it may also spread to lymph nodes and other organs as well.

The finding the natural ingredients for treatment of kidney cancer (renal cell carcinoma) is considered as a dream of many scientist to replace the long term chemotherapy adverse effect of conventional medicine. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi centers.

Recent studies back by some prominent institutions suggested that green tea(1), coffee(4) and grape(7) may be next generation of natural ingredients for reduced risk and treatment of kidney cancer (renal cell carcinoma) due to their phytochemicals in induced apoptosis in several human cell lines.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

According to the study lead by the Agricultural University of Georgia, green tea extract GTE and corresponding nanocomposites may be effective for treatment as auxiliary agents in cancer chemotherapy(1). Dr, The incidence of renal cell carcinoma (RCC) is high in Western and Northern Europe and North America, and low in Asia. and the research team at the in the investigation of prevalence of higher incidence of renal cell carcinoma (RCC) in Western and Northern Europe and North America,in comparison of Asia counter part, insisted that the differences of the pervasiveness of renal cell carcinoma (RCC) may be due to chronic tea drinking(2).
In a cohort included 47,997 males and 66,520 females aged 40 years and older study, Dr. Washio M and colleagues at the Sapporo Medical University School of Medicine said, "consumption of black tea were associated with an increased risk of kidney cancer death(3).

Coffee drink made from roasted coffee beans is considered as one most popular beverage in Western countries may also consist the property in ameliorate risk of kidney cancer. According to the Keimyung University, its phytochemical cafestol, has been reported for its tumor cell growth inhibitory activity and anti-carcinogenic activity, including kidney cancer through modulating multiple components in apoptotic response of human renal Caki cell line(4).
Kahweol, a coffee-specific diterpene, found in the beans of Coffea arabica, also exhibited anti kidney cancer effects in down regulating pro apoptosis in Bcl-2 and anti-apoptotic regulator in c-FLIP pathways(5).
Dr. Lee JE and colleagues at the Brigham and Women's Hospital and Harvard Medical School said," Our findings provide strong evidence that neither coffee nor tea consumption increases renal cell cancer risk. Instead, greater consumption of coffee and tea may be associated with a lower risk of renal cell cancer"(6).

Resveratrol (Res) is a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape may also be potential ingredient for treatment of kidney cancer. According to the Marshall University, resveratrol reduced risk of kidney cancer through diminished cisplatin in vitro renal toxicity and modify the development of oxidative stress(7) as well as protecting kidney damage against exposure to arsenic(9).
Dr. Yang R and colleagues at the Xinxiang Medical University said, "Res significantly inhibits the proliferation of 786-0 cells and exerts an antitumor effect by suppressing the expression of the VEGF gene in regulation of the growth of new blood vessels"(8).

The discovery of combined ingredients of green tea(1), coffee(4) and grape(7) may act as a cornerstone for induction of further investigation of the effectiveness of natural smoothie in reduced risk and treatment of kidney cancer.
People who are at increased risk of kidney cancer due to family history, gene mutation, obesity.....should drink at least one serving daily and people with kidneycancer should drink no more than 4 serving a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

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(1) Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity by Zaletok SP1, Gulua L2, Wicker L3, Shlyakhovenko VA1, Gogol S1, Orlovsky O1, Karnaushenko OV1, Verbinenko A1, Milinevska V1, Samoylenko O1, Todor I1,Turmanidze T2.(PubMed)
(2) Risk factors for renal cell carcinoma in a Japanese population by Washio M1, Mori M, Mikami K, Miki T, Watanabe Y, Nakao M, Kubo T, Suzuki K, Ozasa K, Wakai K, Tamakoshi A.(PubMed)
(3) Risk factors for kidney cancer in a Japanese population: findings from the JACC Study by Washio M1, Mori M, Sakauchi F, Watanabe Y, Ozasa K, Hayashi K, Miki T, Nakao M, Mikami K, Ito Y, Wakai K, Tamakoshi A; JACC Study Group.(PubMed)
(4) Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation by Choi MJ1, Park EJ, Oh JH, Min KJ, Yang ES, Kim YH, Lee TJ, Kim SH, Choi YH, Park JW, Kwon TK.(PubMed)
(5) The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP by Um HJ1, Oh JH, Kim YN, Choi YH, Kim SH, Park JW, Kwon TK.(PubMed)
(6) Intakes of coffee, tea, milk, soda and juice and renal cell cancer in a pooled analysis of 13 prospective studies by Lee JE1, Hunter DJ, Spiegelman D, Adami HO, Bernstein L, van den Brandt PA, Buring JE, Cho E, English D, Folsom AR, Freudenheim JL, Gile GG,Giovannucci E, Horn-Ross PL, Leitzmann M, Marshall JR, Männistö S, McCullough ML, Miller AB, Parker AS, Pietinen P, Rodriguez C, Rohan TE, Schatzkin A,Schouten LJ, Willett WC, Wolk A, Zhang SM, Smith-Warner SA.(PubMed)
(7) Resveratrol attenuates cisplatin renal cortical cytotoxicity by modifying oxidative stress by Valentovic MA1, Ball JG2, Brown JM2, Terneus MV3, McQuade E2, Van Meter S2, Hedrick HM2, Roy AA2, Williams T2.(PubMed)
(8) Inhibitory effect of resveratrol on the expression of the VEGF gene and proliferation in renal cancer cells by Yang R1, Zhang H, Zhu L.(PubMed)
(9) Protective effect of resveratrol on arsenic trioxide-induced nephrotoxicity in rats by Zhang W1, Liu Y2, Ge M1, Jing J1, Chen Y1, Jiang H1, Yu H1, Li N1, Zhang Z1.(PubMed)

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