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Sunday, July 8, 2012

Soy protein and antibiotic release, bacterial inhibition and cellular response

 Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the study of soy protein isolate (SPI)  as a matrix for wound-dressing applications, posted in PubMed, found that The cytotoxicity and in vitro biocompatibility of these films were also examined. The gentamicin release profiles exhibited a moderate burst effect followed by a decreasing release rate, which was maintained for at least 4 weeks, thus enabling a suitable bacterial inhibition effect. The materials released from the films during an indirect cytotoxicity test were found to be safe, except for a slight inhibitory effect in the presence of high concentrations of glycerol. The biocompatibility test showed confluent cell cultures in close proximity to the SPI films.

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