Posted by Chantel M. research contributed by US National Library of Medicine National Institutes of Health
the study to assesst he effects of vehicles on the in vitro topical
delivery from saturated solutions such as aqueous buffers and soybean
oil. posted in PubMed, showed that the isoflavones in a non-ionized form (pH 6) showed higher skin
deposition compared to the ionized form (pH 10.8). Soybean oil reduced
the isoflavone amount retained in the skin, especially for genistein.
Genistein generally exhibited greater skin absorption than did daidzein.
However, daidzein permeation was enhanced when an aglycone mixture was
used as the active ingredient. An eutectic effect was proposed as the
enhancing mechanism. In vivo skin deposition showed a linear correlation
with the in vitro results. The safety profiles suggested no or only
negligible stratum corneum disruption and skin erythema by topical
application of soy isoflavones.
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