Topical delivery and potential dermal use of soy isoflavones

Posted by Chantel M. research contributed by US National Library of Medicine National Institutes of Health   
In the study to assesst he effects of vehicles on the in vitro topical delivery from saturated solutions such as aqueous buffers and soybean oil. posted in PubMed, showed that the isoflavones in a non-ionized form (pH 6) showed higher skin deposition compared to the ionized form (pH 10.8). Soybean oil reduced the isoflavone amount retained in the skin, especially for genistein. Genistein generally exhibited greater skin absorption than did daidzein. However, daidzein permeation was enhanced when an aglycone mixture was used as the active ingredient. An eutectic effect was proposed as the enhancing mechanism. In vivo skin deposition showed a linear correlation with the in vitro results. The safety profiles suggested no or only negligible stratum corneum disruption and skin erythema by topical application of soy isoflavones.

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