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Friday, May 29, 2015

Endometriosis and Vitamins: The Effects of Vitamin B2

Posted by Chantel Martiromo, Research article by Kyle J. Norton


During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

The Vitamin B2
Vitamin B2 is water soluble, also known as riboflavin. It has a chemical compound formula of C17H20N4O6. Like many other vitamin B complexes, it plays an important role in providing energy to our body by the metabolism of fat, carbohydrates and protein.

The Health effects
1. Red blood cell formation
Vitamin B2 includes the active co-enzyme forms of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) that helps to transport vitamin b2 into the red blood cell as well as maintaining the red blood cell formation(113)

 2. Strengthens the immune system(114)
Vitamin B2 is an antioxidant that helps to rejuvenate the immune system caused by toxins accumulated in the liver that helps to maintain our body's function fighting against any abnormality of cell growth including abnormal endometrial cells(115) and to maintain normal cell division or cell growth which decreases the risk of cell abnormality and prevent endometrial cells to grow somewhere else in the body excluding the endometrium.

3. Migraine(118)(119)(120)
The Riboflavin that is found in Vitamin B2 has shown beneficial results by assisting in decreasing the time as well as the frequency in which one gets a migraine headache due to symptoms of endometriosis during menstruation.

4. Nervous system(116)
Vitamin B2 can assist with alleviating stress as well as reducing symptoms of depression that are brought on by digestive disorders that generally affects women with endometriosis during the menstrual cycle(117).

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References
(113) Covalent attachment of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) to enzymes: the current state of affairs by M. Mewies, W. S. McIntire, and N. S. Scrutton(PubMed)
(114)[Effect of some vitamins on activity of immunocompetent cells].[Article in Russian] by Nezgovorov DV.(PubMed)
(115)An influence of immunomodulation on Th1 and Th2 immune response in endometriosis in an animal model. by Szymanowski K1, Niepsuj-Biniaś J, Dera-Szymanowska A, Wołuń-Cholewa M, Yantczenko A, Florek E, Opala T, Murawski M, Wiktorowicz K.(PubMed)
(116)Attenuated neuroprotective effect of riboflavin under UV-B irradiation via miR-203/c-Jun signaling pathway in vivo and in vitro by Tripathi AK, Dwivedi A, Pal MK, Rastogi N, Gupta P, Ali S, Prabhu MB, Kushwaha HN, Ray RS, Singh SK, Duggal S, Narayan B, Mishra DP1.(PubMed)
(117)Estimation of vitamin needs--riboflavin, vitamin B6 and ascorbic acid-according to blood parameters and functional-cognitive and emotional indices in a selected well-established group of elderly in a home for the aged in Israel by Dror Y1, Stern F, Nemesh L, Hart J, Grinblat J.(PubMed)
(118)Effectiveness of riboflavin in pediatric migraine prevention by Sherwood M1, Goldman RD.(PubMed)
(119)Riboflavin and migraine: the bridge over troubled mitochondria by Colombo B1, Saraceno L, Comi G.(PubMed)
(120) Endometriosis is associated with prevalence of comorbid conditions in migraine by Tietjen GE1, Bushnell CD, Herial NA, Utley C, White L, Hafeez F.(PubMed)

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