Endometriosis and Vitamins : The Effects Of Vitamin B1

Posted by Chantel Martiromo, Research article by Kyle J. Norton

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

The Vitamins
Vitamin B1 is one of the members of the vitamin B complex, it is also known as thiamin or thiamine. It's most common form is a colorless chemical compound with the formula C12H17N4OS. It was discovered in 1910 by Umetaro Suzuki in Japan. It is a water soluble vitamin, therefore it can be stored in the body and is required to be taken regularly.


The Health Effects(103)
Women with endometriosis are found to have vitamin B complex deficiency during the menstrual cycle. It is not known if it is caused by unhealthy diet or the inability of digestive absorption.
a) Level of estrogen(105)
Vitamin B1 helps to detoxify the liver which may be caused by intake of of alcohol, smoking and heavy metals. A strong liver is particularly important for secretion of cholesterol in breaking down estrogen that causes menstrual cramps as well as hormone balancing in the body(104).
b) Immune system(107)
Vitamin B1 is an antioxidant that helps to strengthen the immune system against the forming of free radicals, endometrial implants, and adhesion somewhere else in the body except the endometrium(106).
c) Red blood cells(108)
Study shows that vitamin B1 helps to normalize the activity of an enzyme called transketolase in red blood cells resulting in increased amounts of the two proteins THTR-1 and RFC-1 which helps to transport thiamine into red blood cells. This increases the production of red blood cells in the bloodstream.
d) Nervous system(109)(112)
It helps to reduce tension of the nervous system as a resulting of converting carbohydrates to energy which is necessary for the proper functions of the nervous system. Thereby it reduces symptoms of endometriosis in some women such as anxiety, depression, and mood swings(110).
e) Intestine muscle tone
Vitamin B1 helps to secrete hydrochloric acid in the stomach which is essential for the complete digestion of food particles and decreases the risk of nutrient deficiency causing hormone imbalance in the menstrual cycle(111)(112).

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References
(103) A prospective cohort study of Vitamins B, C, E, and multivitamin intake and endometriosis.

Darling AM¹, Chavarro JE², Malspeis S³, Harris HR⁴, Missmer SA⁵.(PubMed)

(104) Hepatocyte susceptibility to glyoxal is dependent on cell thiamin content by Shangari N¹, Mehta R, O'brien PJ.(PubMed)
(105) [Action of vitamin B1 on estrogen employed as inhibitors of lactation].[Article in Undetermined Language]by DUMONT M, GUIRAN G.(PubMed)
(106)An influence of immunomodulation on Th1 and Th2 immune response in endometriosis in an animal model by Szymanowski K¹, Niepsuj-Biniaś J, Dera-Szymanowska A, Wołuń-Cholewa M, Yantczenko A, Florek E, Opala T, Murawski M, Wiktorowicz K.(PubMed)
(107)Thiamin function, metabolism, uptake, and transport by Manzetti S¹, Zhang J, van der Spoel D.(PubMed
(108)Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients(Warwick)
()[Effect of diet on distribution of vitamin B1 in sections of the nervous system].[Article in Undetermined Language]by ZAPRUDSKAIA DS.(PubMed)
(109)The social and psychological impact of endometriosis on women's lives: a critical narrative review. by Culley L¹, Law C, Hudson N, Denny E, Mitchell H, Baumgarten M, Raine-Fenning N.(PubMed)
(110)[2 cases of digestive system endometriosis].[Article in French] by Hoyez A, Renaux J, Conreur Y, Van Cauter J, Ligny G.(PubMed)
(111)Chronic pelvic pain in endometriosis: an overview by Triolo O¹, Laganà AS, Sturlese E.(PubMed)
(112)Constipation in patients with thiamine deficiency after Roux-en-Y gastric bypass surgery. by Shah HN¹, Bal BS, Finelli FC, Koch TR.(PubMed)