Posted by Chantel M. Contributed by US National
Library of Medicine National Institutes of Health
In the study to assess "Daidzein and genistein glucuronides in vitro are weakly estrogenic
and activate human natural killer cells at nutritionally relevant
concentrations" by Zhang Y, Song TT, Cunnick JE, Murphy PA, Hendrich S., posted in US National Library of Medicine National Institutes of Health, researchers found that The glucuronides only inhibited NK cytotoxicity at 50 micromol/L. Isoflavones,
and especially the isoflavone glucuronides, enhanced activation of NK
cells by interleukin-2 (IL-2), additively. At physiological
concentrations, DG and GG were weakly estrogenic, and they activated
human NK cells in nutritionally relevant concentrations in vitro,
probably at a site different from IL-2 action.
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