During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.
1. Immune system
Chaste tree contains irioid glycoside (570), a plant element that helps to increase the secondary metabolism which strengthens our immune system to fight inflammation(3), abnormal cell growth(570), and the invasion of virus(570).
2. Nervous system(571)
Irioids also helps to release the tension of overactive cells in the brain during menstrual cycle resulting in lowering the symptoms of endometriosis such as depression, anxiety, craving, etc.(573).
Some women with endometriosis may experience heavy flow during menstruation caused by the breaking off of the small vein in the abdomen. Isoflavones in the chaste tree berry helps to strengthen the capillary wall, thus reducing the flow and the tension of overactive uterine muscles(574) that cause menstrual pain(572).
4. Hormone balancing(6)
Chaste tree berry contains high levels of plant progesterone which is necessary for women with endometriosis to balance the levels of estrogen(575)(576) that cause menstrual cramps(577).
5. Absence of period
Since absence of period may be caused by high levels of hyperprolactinaemia(579), affecting the function of ovaries in ovulation. Chaste tree reduces levels of prolactinaemia, which is necessary to bring on the menstruation(578).
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(570) Iridoid glycoside from the leaves of Clerodendrum volubile beauv. shows potent antioxidant activity against oxidative stress in rat brain and hepatic tissues by Erukainure OL1, Ebuehi OA, Choudhary IM, Adhikari A, Hafizur RM, Perveen S, Muhammad A, Elemo GN.(PubMed)
(571) [Effects of cornel iridoid glycoside on activity of cholinesterases in vitro].[Article in Chinese] By Chu SJ1, Zhang L, Liu G, Zhou WX, Li L.(PubMed)
(572) Anti-inflammatory activity of iridoids and verbascoside isolated from Castilleja tenuiflora by Carrillo-Ocampo D1, Bazaldúa-Gómez S, Bonilla-Barbosa JR, Aburto-Amar R, Rodríguez-López V.(PubMed)
(573) Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus by Loch EG1, Selle H, Boblitz N.(PubMed)
(574) Associations of menstrual pain with intakes of soy, fat and dietary fiber in Japanese women by Nagata C1, Hirokawa K, Shimizu N, Shimizu H.(PubMed)
(575) Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnus castus in the treatment of climacteric complaints: a systematic review by Laakmann E1, Grajecki D, Doege K, zu Eulenburg C, Buhling KJ.(PubMed)
(576) Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry) by Liu J1, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR.(PubMed)
(577) Complementary and alternative medicine (CAM) in reproductive-age women: a review of randomized controlled trials by Fugh-Berman A1, Kronenberg F.(PubMed)
(578) Evaluation and management of adolescent amenorrhea byDeligeoroglou E1, Athanasopoulos N, Tsimaris P, Dimopoulos KD, Vrachnis N, Creatsas G.(PubMed)
(579) Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials by van Die MD1, Burger HG, Teede HJ, Bone KM.(PubMed)