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Tuesday, February 16, 2016

The smoothie of Green Tea, Carrot and Strawberry for reduced Risk and Treatment of Fibroids back by Respectable Institutions

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and Treatment of  Fibroids
Yield: 2 serving (about 8 ounce each)
11/4 cup strawberry
1/4 cup carrot
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of fibroids  is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Fibroids also known as uterine fibroids, is a condition of irregular cell growth of non cancerous tumor from the muscle layers of the uterus.
Recent studies suggested that scientist in some research centers have found the naturally potential ingredients, such as Green tea(1), Carrot(4) and Strwberry(6) for reduced risk and treatment for
Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. Its phytochemical, epigallocatechin gallate (EGCG),  dramatically reduced the volume and weight of fibroids tumors at 4 and 8 weeks on rat leiomyoma (ELT3) cells in vitro and in a nude mice mode(1).
In a pilot randomized controlled clinical study, epigallocatechin gallate (EGCG) also inhibited the Uterine fibroids, significantly reduced fibroid-specific symptom severity as well as improved quality of life of patients(2).
Dr. Ozercan IH and the research team at the University of Firat said,"dietary supplementation with EGCG reduces the incidence and size of spontaneously occurring leiomyoma of the oviduct" in Japanese quail study(3).

Lycopene, a major phytochemical and antioxidant supplementation, found in tomato, exhibited a decreased incidence of leiomyomas in the oviduct of Japanese quail, according to the University of Firat(3).
According to Dr. Sahin K1 and research team at the Firat University, lycopene intake reduced risk leiomyomas (fibroids), benign tumors of the uterus affecting millions of women through its anti inflammatory activities in cell cycle arrest pathways(4).
In fact, in a 6627 incident cases of UL diagnosed by ultrasonography, dietary vitamin A is associated to reduce risk of uterine leiomyomata, according to the Slone Epidemiology Center at Boston University(5).

Flavonoid, a class of phytochemical found abundantly in strawberry, including apigenin and luteolin inhibited proliferation of of human leiomyomal smooth muscle cells, through significantly reduced cell numbers in culture, arrested cell proliferation, and induced cells apoptosis via down-regulated the IGF-I expression in growth hormone production(6).

Flavopiridol is a potent CDK inhibitor exhibited antiproliferative effect against Fibroids as flavonoid compound through cell cycle phase I arrest, according to the joint study lead by the Keimyung University School of Medicine(7).

The combined epigallocatechin gallate (EGCG), lycopene and apigenin and luteolin, found in green tea, carrot and strawberry respectively may contribute to further investigation of therapeutic natural ingredients for reduced risk and treatment of Fibroids
Women who are at increased risk of Fibroids due to family history, genetic mutation,... should drink at least one serving daily and women with Fibroids should drink as much as they can, depending to digestive toleration.

(1) Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice by Zhang D1, Al-Hendy M, Richard-Davis G, Montgomery-Rice V, Sharan C, Rajaratnam V, Khurana A, Al-Hendy A.(PubMed)
(2) Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study by Roshdy E1, Rajaratnam V, Maitra S, Sabry M, Allah AS, Al-Hendy A.(PubMed)
(3) Chemoprevention of fibroid tumors by [-]-epigallocatechin-3-gallate in quail by Ozercan IH1, Sahin N, Akdemir F, Onderci M, Seren S, Sahin K, Kucuk O.(PubMed)
(4) Lycopene supplementation prevents the development of spontaneous smooth muscle tumors of the oviduct in Japanese quail by Sahin K1, Ozercan R, Onderci M, Sahin N, Gursu MF, Khachik F, Sarkar FH, Munkarah A, Ali-Fehmi R, Kmak D, Kucuk O.(PubMed)
(5) Intake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata by Wise LA1, Radin RG, Palmer JR, Kumanyika SK, Boggs DA, Rosenberg L.(PubMed)
(6) Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by Scutellaria barbata D. Don in vitro: isolation of flavonoids of apigenin and luteolin as acting compounds by Kim DI1, Lee TK, Lim IS, Kim H, Lee YC, Kim CH.(PubMed)
(7) Antitumor effects of flavopiridol on human uterine leiomyoma in vitro and in a xenograft model by Lee HG1, Baek JW2, Shin SJ3, Kwon SH3, Cha SD3, Park WJ3, Chung R1, Choi ES3, Lee GH2, Cho CH4.(PubMed)

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