Broccoli, the Natural Detoxified Remedy

Detoxification is a natural process in the removal of toxic substances of the human body, mainly carried out by the liver and kidney.

According to statistics, thousands of new chemicals are registered for use in foods, medications, household products, and lawn-care products, these types of environmental toxins also add to the risk of chronic illness in long term exposure.

Particularly, these chemical substances induced developmental toxins and neurotoxins exposed to pre- or post-natal babies have never been studied.


Some researchers suggested that detoxification also includes balancing the levels of antioxidants and free radicals.

Overexpression of ROS species caused by toxins accumulation may precipitate the elevation of oxidative stress and cytotoxicity that can lead to healthy cell DNA alternation.

In other words, increased antioxidant enzymes in the production of host antioxidants such as superoxide dismutase, superoxide dismutases (SODs),..... that break down the superoxide anion into oxygen and hydrogen peroxide may decrease oxidative stress by restoring the ratio of free radicals and antioxidants in the body.

Other common symptoms of toxin accumulation in the body include chronic fatigue, body odor, insomnia, food or chemical sensitivities and headaches.


Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anticarcinogenic activity, researchers examined the effects of broccoli sprout extract (BSEx) on liver gene expression and acute liver injury in the rat.

The study included male rats that were divided into the control group fed the AIN-76 diet, and the BSEx group fed the AIN-76 diet containing BSEx for 10-days.


According to the results of rats, after a 10-d feeding period sacrificed, BSEx promoted the expression of genes related to detoxification and glutathione synthesis in normal rat liver.

APAP + BSEx fed groups significantly suppressed the levels of AST (70.91 ± 15.74 IU/mL vs 5614.41 ± 1997.83 IU/mL, P < 0.05) and ALT (11.78 ± 2.08 IU/mL vs 1297.71 ± 447.33 IU/mL, P < 0.05), compared to the APAP group.


Furthermore, he level of antioxidant ezymes, GSH (2.61 ± 0.75 nmol/g tissue vs 1.66 ± 0.59 nmol/g tissue, P < 0.05) and liver GST activity (93.19 ± 16.55 U/g tissue vs 51.90 ± 16.85 U/g tissue, P < 0.05) were significantly increased in the APAP + BSEx group compared with the APAP group.


Although AST (4820.05 ± 3094.93 IU/mL vs 12465.63 ± 3223.97 IU/mL, P < 0.05) and ALT (1808.95 ± 1014.04 IU/mL vs 3936.46 ± 777.52 IU/mL, P < 0.05) levels were significantly suppressed in the D-GalN + BSEx group. However, compared with the D-GalN group, the levels of AST and ALT in the D-GalN + BSEx group were higher than those in the APAP + BSEx group.

And, the level of GST activity was significantly higher in the D-GalN + BSEx group compared with the D-GalN group (98.04 ± 15.75 U/g tissue vs 53.15 ± 8.14 U/g tissue, P < 0.05).

Based on the evidence, researchers said, "BSEx protected the liver from various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis".


Taken altogether, broccoli may be considered liver detoxed functional food, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury by Yoshida K1, Ushida Y1, Ishijima T1, Suganuma H1, Inakuma T1, Yajima N1, Abe K1, Nakai Y. (PubMed)