Curcuma Oil Isolated from Turmeric, A Natural Prevention and Treatment of Insulin Resistance

Insulin resistance is a condition that the signals sent out by hormone insulin were ignored by the cells in your muscles, body fat and liver.

In other words, your cells in the body are no longer respond to the insulin produced by the body to convert the glucose into energy, leading to high levels of glucose in the bloodstream.

The condition can induce more and more production of insulin hormone. Over time, the syndrome can cause overwork of the beta cells in the pancreas that no longer keep up with the demand for insulin, leading to the onset of diabetes.

Insulin resistance is a hallmark of type II diabetes, accompanied by the hallmark of hyperglycemia.

The causes of insulin resistance may be associated with beta-cell gradually died off or insulin receptor sites clogged up with fat and cholesterol.

According to the statistics, approximately, one in three Americans are living with insulin resistance, including half of those aged 60 and older.

The exact causes of insulin resistance are unidentified. Aging and ethnicity, excess body weight, too much fat on the belly, physical inactivity, and smoking are some prevalent factors of the condition.

Some researchers suggested the promotion of the Western diet over the past few decades may be the culprit for the widespread insulin resistance in the West.

Dr. Merat S, the lead scientist at the University of California San Diego said, "the Western diets commonly used in LDLR-/- mice may not only induce atherosclerosis, but also IR, potentially complicating the interpretation of results".

And, "LDLR-/- mice may be used as models to elucidate the effect of IR on atherosclerosis, eg, by feeding them Western diets with or without insulin-sensitizing agents".

The results strongly suggested if you follow the Western diet pattern, you are at a higher risk of insulin resistance compared to people who follow the traditional diet.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
Researchers on finding a potential compound for the prevention and treatment of insulin resistance (IR) evaluated the effect of Curcuma oil (C. oil) isolated from turmeric (Curcuma longa L.) in animal models of diet-induced insulin resistance.

The study included
* Male Golden Syrian hamsters on high fructose diet (HFr) for 12 wk were treated orally with the vehicle, fenofibrate (30 mg/kg) or C. oil (300 mg/kg) for four weeks.

* Wistar rats fed HFr for 12 wk treated orally with C. oil (300 mg/kg) for two weeks.

During the experiment, researchers found that before injection of C. oil, animals fed with HFr diet for 12 wk demonstrated hyperlipidemia, hyperglycemia, hyperinsulinemia, alteration of insulin sensitivity accompanied by symptoms associated with patients with insulin resistance such as increased lipid peroxidation, inflammation, endothelial dysfunction.

Injection of C. oil for 4 weeks in hamster ameliorated HFr-induced hyperlipidemia, hyperglycemia, insulin resistance, oxidative stress, inflammation, endothelial dysfunction.

The effect of C. oil at 300 mg/kg [ ] was comparable with the standard drug fenofibrate.


Rats treated with C. oils for 4 weeks also showed a statistical significance in the amelioration of HFr-induced hyperglycemia and hyperinsulinemia by modulating the expression of the genes involved in lipid and glucose metabolism.

Dr. Singh V the lead scientist wrote in the final report, "High fructose feeding to rats and hamsters led to the development of insulin resistance, hyperglycemia,.....and oxidative stress. C. oil prevented the development of thrombotic complications associated with insulin resistance perhaps by modulating genes involved in lipid and glucose metabolism".


Taken altogether, Curcuma oil (C. oil) isolated from turmeric (Curcuma longa L.) may be considered supplements for the prevention and treatment of insulin resistance, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin and insulin resistance-Molecular targets and clinical evidences by Jiménez-Osorio AS1, Monroy A2, Alavez S. (PubMed)
(2) Curcuma oil ameliorates insulin resistance & associated thrombotic complications in hamster & rat by Singh V, Jain M, Misra A, Khanna V, Prakash P, Malasoni R, Dwivedi AK, Dikshit M, Barthwal MK. (PubMed)
(3) Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet by Merat S1, Casanada F, Sutphin M, Palinski W, Reaven PD. (PubMed)