Healthy Food Amtak Baechu Cabbage Induces Pancreatic Cancer Cells Death

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas aids the digestive system to break down carbohydrates, proteins, and lipids.

Traditional Chinese medicine suggested that the pancreas is a vital organ responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our body.

Pancreatic cancer is a chronic condition characterized by cell growth irregularly in the tissues of the pancreas.

Most cases of pancreas cancer start in the cell on the surface of the inner lining tissue. However, as the cancer progress, the malignant cells of the pancreas, although unusual may travel a far distance away to infect other healthy tissue and organs.

The pancreas cancer was found to be the site of metastasis from renal cell cancer, lung, colon and breast cancers.

According to statistics, every year, approximately, over 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.

The survival rate of pancreatic cancer even diagnosed early is very low compared to other types of cancer. The 5-year survival rate at stage IA pancreatic cancer is only14%.

The exact causes of pancreatic cancer are identified. However, epidemiological studies suggested that the increase in age, family history, race, gender, smoking, being obese or overweight and a medical condition such as diabetes is the most prevalent risk of the disease.

The genetic and acquired genetic mutation of p16 and TP53 and KRAS, BRAF, and DPC4 (SMAD4) were also found in patients with pancreatic cancer.

On finding a potential plant that processes anti-cancer property activity researchers investigated the effects of kimchi prepared using the standard Baechu cabbage and Amtak Baechu cabbage on hepatic cancer cells.

The study included 4 different kimchi samples prepared for this study which are t(1) the standard Baechu cabbage and dry salt treatment method (SK-D); (2) the Amtak Baechu cabbage and dry salt treatment method (AK-D); (3) the standard Baechu cabbage and brine solution treatment method (SK-B); and (4) the Amtak Baechu cabbage and brine solution treatment method (AK-B).


Based on the results of the analysis,
* The liver cancer cells showed a significant increase in cell growth inhibition when exposed to AK-D and AK-B compared with SK-D and SK-B (p < 0.05). At 2.0 mg/mL,

* AK-B and AK-D treatment exerted 2.0 times against the Capan-2 cells, compared with SK-B and SK-D.

* AK-D and AK-B treatment compared with SK-D and SK-B demonstrated a significant increase of tumor-suppressive p21 levels associated with apoptosis and cell cycle arrest.

* AK-B displayed higher ongoing cytotoxic effects compared with AK-D.


Based on the evidence, researchers said,. "Overall, these results indicate that kimchi made with Amtak Baechu cabbage and treated with brine solution (AK-B) had a superior anticancer potential against both types of cancer cells, with the effects being greater in pancreatic cancer cells compared with liver cancer cells".


Taken altogether, cabbage may be considered a functional food for the prevention and treatment of
pancreatic cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Beneficial Outcomes of Kimchi Prepared with Amtak Baechu Cabbage and Salting in Brine Solution: Anticancer Effects in Pancreatic and Hepatic Cancer Cells by Song GH1, Park ES1, Lee SM1, Park DB2, Park KY. (PubMed)