Scientists may have found a bioactive ingredient for the prevention and treatment of hypertension with no side effects, according to studies.
Hypertension is a medical condition characterized by abnormally high blood pressure.
Blood pressure is a measurement of a force against the walls of blood vessels that the heart pumps blood around the body.
Chronic and untreated high blood pressure has been associated epidemiologically with an increased risk of heart disease and stroke.
According to the statistics provided by the American Heart Association, there are over 103 million Americans living with high blood pressure.
In other words, nearly half of all adults in the US have hypertension.
According to the new definition in the measurement of blood pressure, the percentage of U.S. adults with high blood pressure jumped from 32 percent under the old definition to nearly 46 percent.
Most people with mild hypertension can control the blood pressure by a change of lifestyles such as a change to diet and exercise.
There are many prevalent factors associated with the onset of hypertension, including age, ethnicity and gender, diet, physical inactivity, exercise, and smoking.
Some researchers suggested widespread hypertension in obese subjects may be correlated to the promotion of a high-fat diet over the past few decades.
Dr. Lia Taylor, the lead scientist wrote, "Diets high in fat and cholesterol have been linked to weight gain and hypertension, and T cell activation has been suggested to mediate these diet-induced changes in male animal models".
And, "a 4wk-HF diet increased BP and decreased renal anti-inflammatory T cells in female DSS rats. The loss of renal anti-inflammatory T cells is expected to lead to a more pro-inflammatory immune cell profile that may sensitize female DSS rats to HF-diet induced increases in BP".
Tomato is red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, tomatoes are cultivated worldwide for commercial purpose and often in the greenhouse.
On finding a potential compound for the treatment of hypertension with no side effects, researchers assessed whether the addition of standardized tomato extract (STE) or acetylsalicylic acid (ASA) to standard antihypertensive therapy can improve BP control in patients with arterial hypertension (HT).
The study included 82 high-risk hypertensive patients with primary HT at high to a very high total CV risk were randomized in a blinded fashion to one of two groups, i.e. the ASA and STE group.
STE treated group showed a statistically significant reduction in 24-h systolic BP, diastolic BP, and mean arterial pressure values measured in ABPM after four weeks compared to ASA treated group.
Furthermore, after four weeks of treatment, the STE group exhibited a statistically significant reduction in pulse pressure (PP) during the daytime and during 24 h.
Moreover, STE treatment in obese patients also significantly decreased the day PP.
Based on the results, researchers said, "The results of this study show that the addition of STE to standard antihypertensive therapy improves BP control in hypertensive patients with high CV risk. This effect, together with the anti-aggregatory effect, may indicate the pleiotropic effect of tomato extract."
Additionally, in the study of 65 patients with arterial hypertension and high cardiovascular risk. researchers compared the influence of adding acetylsalicylic acid (ASA) or standardized tomato extract (STE) to standard hypotensive therapy on the values of arterial pressure and the daily blood pressure profiles of patients with hypertension and high cardiovascular risk.
All patients evaluated with high-risk of primary hypertension were randomly allocated in a blinded fashion to one of two groups (ASA or STE).
Similar to the aforementioned study, the blood pressure values during the day, during the night, and in 24-h BP profiles obtained with ABPM were significantly lower in the STE group in compared to the ASA group, after 4 weeks of treatment.
The addition of STE to standard hypotensive treatment resulted in a favorable increase in the nocturnal fall of diastolic blood pressure (DBP) (by 6.5%) and mean arterial pressure (MAP) (by 3.3%).
In other words, tomato normalized the blood pressure against the risk of CVD regardless of the levels of blood pressure.
Dr. Osińska AN, the lead scientist wrote in the final report, "The use of STE is significant in HT patients with high total cardiovascular risk; it is associated with better BP control and improvements in the daily BP profile.".
Taken altogether, tomatoes may be considered supplements for the prevention and treatment of hypertension, pending to the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Favourable hypotensive effect after standardised tomato extract treatment in hypertensive subjects at high cardiovascular risk: a randomised controlled trial by Krasińska B1, Osińska A, Krasińska A, Osiński M, Rzymski P, Tykarski A, Krasiński Z. (PubMed)
(2) The influence of adding tomato extract and acetylsalicylic acid to hypotensive therapy on the daily blood pressure profiles of patients with arterial hypertensionand high cardiovascular risk by Osińska AN1, Begier-Krasińska B1, Rzymski P2, Krasińska A3, Tykarski A1, Krasiński Z. (PubMed)
(3) A High Fat Diet Increases Blood Pressure and Leads to a Renal Proinflammatory Immune Cell Profile in Female Dahl Salt-Sensitive Rats by Lia Taylor, Jacqueline Musall, Babak Baban, Eric J Belin de Chantemele, and Jennifer Sullivan. (Faseb Journal)
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