Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.
Most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions included Parkinson’s, Alzheimer’s, and Huntington’s disease, leading to a negative influence the body's functioning, including balance, movement, talking, breathing, and heart function.
There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition, medical conditions, such as alcoholism, brain cancer or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases.
Other risk factors associated with the disease prevalence are the increase in age, the most consistent risk factor for developing a neurodegenerative disease, especially AD or PD, as the disease has been found over 60% in the population aged 65 and beyond compared to another group.
A prolonged period of toxins, toxic chemicals accumulated that affects the brain function also have a strong impact to induce the onset of the disease.
The progressive loss of neurons induced neurological and neuropsychological signs and symptoms have also been found in comparison to the stage of disease onset of patients.
Dementia is a condition of deterioration of the cognitive ability of memory, thinking, language, judgment, and behavior, gradually.
The loss of mental ability in patients with dementia in most cases is severe enough to interfere with people's every life. Alzheimer's disease is the most common type of dementia in aging people.
According to the statistics, about 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years and above that age.
Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
According to the WHO, neurological disorders, ranging from epilepsy to Alzheimer's disease, from stroke to headache, affect up to one billion people worldwide.
On finding a potential plant that treats age-related diseases, researchers examined the effects sulforaphane (SF), derived from the hydrolysis of the glucosinolate glucoraphanin mainly present in Brassica vegetables, anti-neuroprotective effects
The study included 16 subjects randomized, into 3-phase crossover dietary trial of standard broccoli, high glucosinolate broccoli, and water.
According to the results of the trial,
* Sulforaphane (SF) inhibited the oxidative stress that results from an imbalance of pro-oxidant/antioxidant homeostasis associated with abnormal production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the damage of neurons induced neurodegenerative diseases (NDDs).
* In a neonatal hypoxia/ischemia brain injury model, SF significantly increased Nrf2 and HO-1 expression involved in the production of antioxidants enzymes in the host against oxidative stress accompanied by reduced infarct volume.
* In a rat model of traumatic brain injury (TBI), the postinjury administration of SF reduced the BBB impairment and cerebral edema after TBI.
* In chronic degenerative diseases, SF inhibited the increase of oxidative stress, the impaired protein-folding function of the endoplasmatic reticulum, and deficient proteasome- and autophagic-mediated clearance of damaged proteins accelerated the accumulation of Aβ peptides and Tau protein in AD.
Taken altogether, the consequences of these results suggest that the broccoli process abundantly SF, may be considered a functional food for the prevention and treatment of neurodegenerative diseases (NDDs), pending to the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases by Andrea Tarozzi, 1 Cristina Angeloni, 1 ,* Marco Malaguti, 1 Fabiana Morroni, 2 Silvana Hrelia, 1and Patrizia Hrelia. (PMC)
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