Healthy Food Onion Kills Colon Cancer in Vitro

Colon cancer is a chronic condition caused by irregular cell growth in the colon tissue.

The colon formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Most cases of colon cancer start with the alternation of cells DNA on the surface of the inner lining colon tissue before proliferating into deeper tissues to form a tumor.

Colon cancer is relatively very common, slowly growing and progressing cancer.

According to the statistics provided by the American Cancer Society, in 2019, colorectal cancer including colon and rectal cancer is the third most common cancer diagnosed in both men and women in the United States.


In 2019, 101,420 people in the US will be diagnosed with colon cancer.
The exact causes of colon cancer are unknown. However, out of many risk factors associated with the onset of the disease, inherited syndromes may have a strong implication involved in cancer developing, including
* Familial adenomatous polyposis (FAP):
Familial adenomatous polyposis is an inherited condition in which numbers of benign polyp form mainly in the lining of the large intestine, but they can become malignant due to the mutations in the APC gene inherited from the parents.

* Hereditary non-polyposis colon cancer (HNPCC)
HNPCC, also known as Lynch syndrome. HNPCC) increases the risk of developing colon cancer due to the mutation of genes in repairing DNA damage.

*Turcot syndrome
Turcot syndrome is also a rare inherited condition in which cells become abnormal and form multiple adenomatous colon polyps and eventually turn malignant.

* Peutz-Jeghers syndrome
Peutz-Jeghers syndrome is an autosomal dominant genetic disease with the condition of the development of benign hamartomatous polyps in the gastrointestinal tract and hyperpigmented macules on the lips and oral mucosa due to mutations in the gene STK1.

* MUTYH-associated polyposis
MUTYH is a human gene encoding a DNA glycosylase. Mutations in the gene MUTYH increases the risk of developing colon polyps which eventually become cancerous if the polyps are not removed.

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.


On finding a natural ingredient for the treatment of colon cancer, researchers examined the effects of fisetin, a natural compound found in fruits and vegetables such as strawberries, apples, cucumbers, and onions in HT-29 colon cancer cells.


According to the tested assays, at the ranges from 20-60 micromol/l, Fisetin induced colon cancer cell apoptosis by inhibiting the expression of proteins associated with the antiapoptosis(Bcl-xL and Bcl-2) and promoting the expression of proteins (Bak and Bim) involved in pro-apoptosis.

More precisely, fisetin caused an increase in the protein levels associated with the apoptosis and increased of proteins involved in the suppression of fisetin-induced apoptosis.


The inhibition of cancer cell death was also observed by the effect of Fisetin on the enhanced permeability of the mitochondrial membrane and induced the release of cytochrome c.

Moreover, a gene that suppressed the cancer cell initiation, progression and proliferation such as p53 was also exhibited by Fisetin accompanied by activating the proteins (cleavage of poly (ADP-ribose) polymerase (PARP) associated with cell death programming.


Based on the findings, researchers said, "fisetin induces apoptosis in HCT-116 cells via the activation of the death receptor- and mitochondrial-dependent pathway and subsequent activation of the caspase cascade".

Taken altogether, onion used alone or combined with other remedies may be considered a remedy for the prevention and treatment of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin by Lim DY1, Park JH. (PubMed)