Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
1. Honey, The Rich Golden Liquid May Process Anti Prostate Cancer Potency
2, Honey, Protects the Breast Cells integrity Against the Onset of Breast Cancer
3. Honey Protects Our Skin Pigment Against the Onset of Melanoma Skin Cancer
4. Honey, the Potential Anti-Colon Cancer Functional Food
5. Honey, the Potential Chemo Replacement for the Treatment Cancers, Scientists Say
6. Tualang Honey Which Kills Leukemia Cancer Cells In Vivo and Vitro, Scientists Say
7. Manaku Honey, the Potential Cartilage Repair Functional Food
8. Manuka Honey, the Best for Tissue Regeneration
9. Tualang Honey May Process a Potential for the Prevention and Treatment of Osteosarcoma
10. Tualang Honey Protects the Oral Cells Against Cancer With No Side Effects
11. Honey, The Functional Food Which Kills Bladder Cancer Cells in Vivo and Vitro, Scientists
Find
12. Honey, The Best to Inhibits Chemo-toxicity and ImprovesChemotherapy For Treatment of Cancers
13. Manuka Honey, the Best for the Prevention and Treatment of Acute and Chronic Inflammatory Diseases
14. Manuka Honey (MH) and Tualang Honey (TH), the Potential Natural Antibiotics Alternative with No Side Effects
15. Manuka Honey, The Anti Antioxidants Functional Sweety
16. Honey, the Natural Whole Food for Prevention and Treatment of Dandruff
17. Manuka Honey, the Best Anti-influenza Functional Food
18. Honey, the Anti Varicella Zoster Virus (VZV) Functional Food, According to Studies
19. Honey, Better Than Over the Counter Medicine for Treatment of Acute Cough in Children
20. Thyme Honey, the Potential Anti-Endometrial Cancer Functional Food
21. Monofloral Honey, the Potential Anti- Human immunodeficiency virus HIV-1 Functional Foods
22. Localized Honey, the Best for the Treatment of Allergies with No Side Effects, According to Studies
23. Tualang Honey the Best to Boosts Memory
24. Honey, the Natural Ingredient that Normalizes Your Blood Pressure with No Side Effects
25. Honey, the Heart Friendly Natural Remedy
26. Honey Relives Hangover, Scientists Reveal
27. Manuka Honey, the Best Natural Liquid for Treatment Atopic Dermatitis, Researchers Reveal
28. Tualang Honey, The Potential Anti-Cervical Cancer Functional Food
29. Honey In the Controlling of Obesity
30. Honey Detoxes the Liver Against Toxicity in Vivo, According to Scientists
31. Honey, the Natural Remedy for Influenza with No Side Effects
32. Honey Speeds Up Wound Healing with Anti-infection Activity
33. Honey, the Best for the Treatment of Ocular Demodex and Dry-Eye with No Side Effects
34. Honey, the Natural Treatment of Anxiety Disorder with No Side Effects, According to Studies
35. Honey, the Best Remedy for the treatment of Asthma with No Side Effects
36. Honey Improves the sleep Quality Naturally with No Side Effects, Scientists Say
37. Honey, Eliminates the Bad Breath Instantly
38. Honey, the Best Remedy for Depression with No Side Effects
39. Honey, the Natural Pain Reliever with No Side Effects
40. Honey, the Best for the Treatment of Chronic Cough with No Side Effects
41. Honey, the Best to inhibit the Expression of Oxidative Stress with No Side Effects
42. The Best Remedy for Prevention and Treatment of Stomach Ulcers, According to Studies
43. Honey, the Best Remedy for the Prevention and Treatment of Diarrhea
44. Honey Normalizes the Levels of Blood Cholesterol with No Side Effects
45. Honey, the Best Remedy for the Prevention and Treatment of Reflux Esophagitis
46. Honey, the Herbal Remedy Which Suppresses Osteoarthritis
47. Honey the Magic Cure Gastroenteritis (Stomach Flu)
48. Honey the Best Natural Treatment of High Blood Pressure with No Side Effects, Scientists Say
49. Honey, the Best Natural Remedy for Chronic Otitis Externa With No Side Effects
50. Honey, the Best for treatment of First and Second Degrees of Burns
51. Honey Promotes Drainage of Bile and Pancreatic Duct Against Obstructive Jaundice
52. Honey, the Best Remedy In the Modulation of the Immune System for the Body Needs
53. Honey Protects the Bone Mass with No Side Effect, According to Studies
54. Honey, Antidepressant Functional and Natural Remedy
55. Honey, the Anti Obesity Functional Food
56. Tualang Honey Protects the Neuron Integrity Against Memory Deficits
57. Honey, the Best for the Treatment of Acute and Chronic Infection
58. Honey Improves Sexual Behavior and Fertility In Male Smokers in Vivo
59. 1015. Honey Improved the Digestive Functioning
60. Whole Food Honey, the Best to Speed Up Wound Healing
61. Whole Food Honey, the Best to Inhibit Oxidative Stress-Related Disease-
To Be Continued
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.
Tuesday, April 30, 2019
Phytochemical 3,3'-Diindolylmethane Kills Pancreatic Cancer Cells in Vitro
Pancreatic cancer is a medical condition characterized by irregular cell growth in the tissue of the pancreas.
Most cases of pancreatic cancer start in the cell on the surface of the inner lining of the pancreatic tissue, before penetrating into the deeper layers to form a large and invasive tumor.
At the early stage, patients with pancreatic cancer may be asymptomatic. However, at the later stage, besides the common symptoms shared by all types of cancer such as unintended weight loss, loss of appetite, fatigue and gastrointestinal discomforts, patients with the condition may also experience localized symptoms such as internal bleeding and severe pain due to the oversize tumor which suppresses the nerve cells and blood vessels.
According to the statistic, in the US, every year, approximately 55,440 adults (29,200 men and 26,240 women) are diagnosed with pancreatic cancer.
The 5-year survival rate including all stages of people with pancreatic cancer is 8%, compared to 32% of cancer detected at an early stage.
The exact causes of pancreatic cancer are identified. However, epidemiological studies suggested that the increase in age, family history, race, gender, smoking, being obese or overweight and a medical condition such as diabetes is a most prevalent risk of the disease.
Some researchers indicated that genetic preposition may have a strong implication in the initiation of the onset of pancreatic cancer.
Dr. Alison P. Klein wrote, "These consist of high penetrance genes including BRCA2 or PALB2, to more common genetic variation associated with a modest increase risk of pancreatic cancer such as genetic variation at the ABO blood group locus".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
On finding a bioactive ingredient for the treatment of pancreatic cancer, researchers investigated the 3,3'-Diindolylmethane (DIM), ring-substituted DIMs and 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl) methanes (C-DIMs) against the growth of Panc-1 and Panc-28 pancreatic cancer cells.
According to assays, Both DIM and DIM-C-pPhtBu induced pancreatic cancer cells. apoptosis observed by the increased endoplasmic reticulum (ER) staining and ER calcium release in Panc-1 cells.
Glucose-regulated protein 78, a protein in the endoplasmic reticulum in the cell played an important role in cellular adaptation and oncogenic survival also increased by the injection of both DIM and DIM-C-pPhtBu.
Furthermore, both DIM and DIM-C-pPhtBu. also exerted a significant activity against the pancreatic cancer cells through increasing the C/EBP homologous transcription factor in the regulation of cells apoptosis in response to cellular oxidative stress, similar to those of thapsigargin (Tg).
Moreover, DIM/DIM-C-pPhtBu- and Tg-induced ER stress in facilitating the pancreatic cancer cells death through cell death receptors and proteins associated with programming cell death.
Dr. the lead scientists after taking into account co and confounders wrote in the final report, "Activation of both receptor-dependent and receptor-independent (ER stress) pathways by DIM and DIM-C-pPhtBu in pancreatic cancer cells enhances the efficacy and potential clinical importance of these compounds for cancer chemotherapeutic applications".
Additionally, in order to reveal more information about DIM induced pancreatic cancer cells apoptosis, researchers analyzed the DIM effect by examing the process through multiple molecular assays.
According to the Western blot analysis, 3,3'-diindolylmethane (DIM) a chemopreventive agent, specifically its more bioavailable formulation, B-DIM, inhibited Par-4, in L3.6pl and Colo-357 pancreatic cancer cells at low doses (20 micromol/L).
At similar doses, DIM reduced cell viability and caused cell growth inhibition and apoptosis.
Also, pretreatment of DIM sensitized the cells to the cytotoxic action of chemotherapeutic drug gemcitabine.
In other words, DIM not only processed anti-pancreatic cancer cells proliferation and induced apoptosis but also promoted the chemotherapeutic drug cytotoxic activity against pancreatic cancer cells.
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of pancreatic cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5,Abdelrahim M1, Newman K, Vanderlaag K, Samudio I, Safe S. (PubMed)
(2) Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM) by Azmi AS1, Ahmad A, Banerjee S, Rangnekar VM, Mohammad RM, Sarkar FH. (PubMed)
(3) Genetic Susceptibility to Pancreatic Cancer by Alison P. Klein. (PMC)
Most cases of pancreatic cancer start in the cell on the surface of the inner lining of the pancreatic tissue, before penetrating into the deeper layers to form a large and invasive tumor.
At the early stage, patients with pancreatic cancer may be asymptomatic. However, at the later stage, besides the common symptoms shared by all types of cancer such as unintended weight loss, loss of appetite, fatigue and gastrointestinal discomforts, patients with the condition may also experience localized symptoms such as internal bleeding and severe pain due to the oversize tumor which suppresses the nerve cells and blood vessels.
According to the statistic, in the US, every year, approximately 55,440 adults (29,200 men and 26,240 women) are diagnosed with pancreatic cancer.
The 5-year survival rate including all stages of people with pancreatic cancer is 8%, compared to 32% of cancer detected at an early stage.
The exact causes of pancreatic cancer are identified. However, epidemiological studies suggested that the increase in age, family history, race, gender, smoking, being obese or overweight and a medical condition such as diabetes is a most prevalent risk of the disease.
Some researchers indicated that genetic preposition may have a strong implication in the initiation of the onset of pancreatic cancer.
Dr. Alison P. Klein wrote, "These consist of high penetrance genes including BRCA2 or PALB2, to more common genetic variation associated with a modest increase risk of pancreatic cancer such as genetic variation at the ABO blood group locus".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
On finding a bioactive ingredient for the treatment of pancreatic cancer, researchers investigated the 3,3'-Diindolylmethane (DIM), ring-substituted DIMs and 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl) methanes (C-DIMs) against the growth of Panc-1 and Panc-28 pancreatic cancer cells.
According to assays, Both DIM and DIM-C-pPhtBu induced pancreatic cancer cells. apoptosis observed by the increased endoplasmic reticulum (ER) staining and ER calcium release in Panc-1 cells.
Glucose-regulated protein 78, a protein in the endoplasmic reticulum in the cell played an important role in cellular adaptation and oncogenic survival also increased by the injection of both DIM and DIM-C-pPhtBu.
Furthermore, both DIM and DIM-C-pPhtBu. also exerted a significant activity against the pancreatic cancer cells through increasing the C/EBP homologous transcription factor in the regulation of cells apoptosis in response to cellular oxidative stress, similar to those of thapsigargin (Tg).
Moreover, DIM/DIM-C-pPhtBu- and Tg-induced ER stress in facilitating the pancreatic cancer cells death through cell death receptors and proteins associated with programming cell death.
Dr. the lead scientists after taking into account co and confounders wrote in the final report, "Activation of both receptor-dependent and receptor-independent (ER stress) pathways by DIM and DIM-C-pPhtBu in pancreatic cancer cells enhances the efficacy and potential clinical importance of these compounds for cancer chemotherapeutic applications".
Additionally, in order to reveal more information about DIM induced pancreatic cancer cells apoptosis, researchers analyzed the DIM effect by examing the process through multiple molecular assays.
According to the Western blot analysis, 3,3'-diindolylmethane (DIM) a chemopreventive agent, specifically its more bioavailable formulation, B-DIM, inhibited Par-4, in L3.6pl and Colo-357 pancreatic cancer cells at low doses (20 micromol/L).
At similar doses, DIM reduced cell viability and caused cell growth inhibition and apoptosis.
Also, pretreatment of DIM sensitized the cells to the cytotoxic action of chemotherapeutic drug gemcitabine.
In other words, DIM not only processed anti-pancreatic cancer cells proliferation and induced apoptosis but also promoted the chemotherapeutic drug cytotoxic activity against pancreatic cancer cells.
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of pancreatic cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5,Abdelrahim M1, Newman K, Vanderlaag K, Samudio I, Safe S. (PubMed)
(2) Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM) by Azmi AS1, Ahmad A, Banerjee S, Rangnekar VM, Mohammad RM, Sarkar FH. (PubMed)
(3) Genetic Susceptibility to Pancreatic Cancer by Alison P. Klein. (PMC)
Monday, April 29, 2019
Herbal Ginger, A Natural Treatment for Parkinson disease (PD) with No Side Effects
Parkinson disease (PD) is a disabling, progressive condition caused by the gradual loss of neurons cells.
In other words, PD is a cognitive deficit associated with the interruption of frontal-subcortical loops that facilitate cognition and parallel the motor loop and loss of substantia nigra pars compacta (SNc) dopamine (DA) neurons.
According to the statistics, more than 10 million people worldwide are living with PD. In the US, every year, 60,000 adults are diagnosed with PD. Approximately, over 95% of people diagnosed with PD are over 50 years of age.
PD can be classified into 5 stages, depending on the severity
* Stage 1
In stage 1, symptoms of PD do not interfere with daily activities.
* Stage 2
In stage 2, the symptoms start to get worse over time. Making living alone to carry daily task now may be difficult.
* Stage 3
The symptoms are now interfering with daily activity, including the impairment of dressing and eating.
* Stage 4
The symptoms are severe with limited functioning, Patients in this stage have required the help of others to carry out daily activity.
* Stage 5, the most advanced stage of PD. Around-the-clock care is required for all activities.
The exact causes of PD are unidentified. However, the epidemiological study suggested that age and sex, genetic factors, head trauma, exposure to chemicals, long-term use of certain medications and drugs are some of the prevalent risks of Parkinson disease (PD).
Some researchers suggested lifelong cigarette smoking may have a strong impact on the risk of PD.
Dr. Chaoran Ma, the lead scientist wrote, "Evidence from epidemiological studies suggest a relationship between cigarette smoking and low risk of Parkinson disease (PD). As a major component of tobacco smoke, nicotine has been proposed to be a substance for preventing against PD risk, with a key role in regulating striatal activity and behaviors mediated through the dopaminergic system".
And, "Animal studies also showed that nicotine could modulate dopamine transmission and reduce levodopa-induced dyskinesias".
The results strongly suggested that if you smoke, your risk of PD is increased substantially compared to never smoke healthy adults.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers in the concern about Parkinson's disease (PD) associated with the progressive degeneration of dopaminergic neurons in the nigrostriatal system and dopamine (DA) depletion in the striatum, examined the Zingerone and eugenol, essential oils extracted from ginger and cloves, free radical scavenging and antioxidant effects.
Rodents used in the study were induced PD by injected with 6-hydroxydopamine (6-OHDA) intracerebroventricularly.
According to the assays, daily oral administration of eugenol/zingerone and injection of L-DOPA intraperitoneally for 4 weeks following a single 6-OHDA injection did not improve abnormal behaviors induced by L-DOPA treatment.
Where 3-(3,4-Dihydroxyphenyl)-L-alanine (L-DOPA) is the most popular therapeutic medicine for treating PD with adverse effects.
However, injection of zingerone and eugenol alone enhanced the reduction of striatal DA and its metabolites and zingerone decreased the oxidative stress and increased the levels of antioxidants such as glutathione peroxidase and the oxidized L-ascorbate in the striatum.
In other words, compared to the effects of zingerone against PD through its antioxidant activity, pre-treatment with zingerone or eugenol do not prevent 6-OHDA-induced DA depression by preventing lipid peroxidation.
Taken altogether, ginger may be considered a functional spice for the prevention and treatment of PD, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Effects of zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] and eugenol [2-methoxy-4-(2-propenyl)phenol] on the pathological progress in the 6-hydroxydopamine-induced Parkinson's disease mouse model by Kabuto H1, Yamanushi TT. (PubMed)
(2) Nicotine from cigarette smoking and diet and Parkinson disease: a review by Chaoran Ma,1 Yesong Liu,2 Samantha Neumann,3 and Xiang Gao. (PMC)
(3) Stages of Parkinson's by Parkinson's Foundation
In other words, PD is a cognitive deficit associated with the interruption of frontal-subcortical loops that facilitate cognition and parallel the motor loop and loss of substantia nigra pars compacta (SNc) dopamine (DA) neurons.
According to the statistics, more than 10 million people worldwide are living with PD. In the US, every year, 60,000 adults are diagnosed with PD. Approximately, over 95% of people diagnosed with PD are over 50 years of age.
PD can be classified into 5 stages, depending on the severity
* Stage 1
In stage 1, symptoms of PD do not interfere with daily activities.
* Stage 2
In stage 2, the symptoms start to get worse over time. Making living alone to carry daily task now may be difficult.
* Stage 3
The symptoms are now interfering with daily activity, including the impairment of dressing and eating.
* Stage 4
The symptoms are severe with limited functioning, Patients in this stage have required the help of others to carry out daily activity.
* Stage 5, the most advanced stage of PD. Around-the-clock care is required for all activities.
The exact causes of PD are unidentified. However, the epidemiological study suggested that age and sex, genetic factors, head trauma, exposure to chemicals, long-term use of certain medications and drugs are some of the prevalent risks of Parkinson disease (PD).
Some researchers suggested lifelong cigarette smoking may have a strong impact on the risk of PD.
Dr. Chaoran Ma, the lead scientist wrote, "Evidence from epidemiological studies suggest a relationship between cigarette smoking and low risk of Parkinson disease (PD). As a major component of tobacco smoke, nicotine has been proposed to be a substance for preventing against PD risk, with a key role in regulating striatal activity and behaviors mediated through the dopaminergic system".
And, "Animal studies also showed that nicotine could modulate dopamine transmission and reduce levodopa-induced dyskinesias".
The results strongly suggested that if you smoke, your risk of PD is increased substantially compared to never smoke healthy adults.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers in the concern about Parkinson's disease (PD) associated with the progressive degeneration of dopaminergic neurons in the nigrostriatal system and dopamine (DA) depletion in the striatum, examined the Zingerone and eugenol, essential oils extracted from ginger and cloves, free radical scavenging and antioxidant effects.
Rodents used in the study were induced PD by injected with 6-hydroxydopamine (6-OHDA) intracerebroventricularly.
According to the assays, daily oral administration of eugenol/zingerone and injection of L-DOPA intraperitoneally for 4 weeks following a single 6-OHDA injection did not improve abnormal behaviors induced by L-DOPA treatment.
Where 3-(3,4-Dihydroxyphenyl)-L-alanine (L-DOPA) is the most popular therapeutic medicine for treating PD with adverse effects.
However, injection of zingerone and eugenol alone enhanced the reduction of striatal DA and its metabolites and zingerone decreased the oxidative stress and increased the levels of antioxidants such as glutathione peroxidase and the oxidized L-ascorbate in the striatum.
In other words, compared to the effects of zingerone against PD through its antioxidant activity, pre-treatment with zingerone or eugenol do not prevent 6-OHDA-induced DA depression by preventing lipid peroxidation.
Taken altogether, ginger may be considered a functional spice for the prevention and treatment of PD, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Effects of zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] and eugenol [2-methoxy-4-(2-propenyl)phenol] on the pathological progress in the 6-hydroxydopamine-induced Parkinson's disease mouse model by Kabuto H1, Yamanushi TT. (PubMed)
(2) Nicotine from cigarette smoking and diet and Parkinson disease: a review by Chaoran Ma,1 Yesong Liu,2 Samantha Neumann,3 and Xiang Gao. (PMC)
(3) Stages of Parkinson's by Parkinson's Foundation
Herbal Artichoke, The Best Reactive Oxygen Species Inhibitor, Researchers Find
Artichoke may be used as a natural ingredient to inhibit the overexpression of reactive oxygen species (ROS), according to studies.
Reactive oxygen species (ROS) or free radicals are highly reactive chemical species containing oxygen molecules. In other words, free radicals are unstable atoms with an unpaired electron in the outer ring.
Therefore, in order to become stable, free radicals must either donate or steal an electron from other atoms, leading to a chain reaction that can not be stopped until all electrons are paired or inhibited by antioxidants.
Believe it or not, free radicals in moderate amounts are needed for our body for cell signaling and activation of several transcriptional factors, apoptosis, immunity, and differentiation. However, overexpression of free radicles can cause damage to protein, lipid and cell alternation, leading a number of chronic illness, including cancer.
Free radicals are generated as metabolic by-products by biological systems. Environmental stressors (i.e., the air we breathe, UV, ionizing radiations, pollutants, and heavy metals) and xenochemicals are also found to contribute to the great increase of ROS production.
In a healthy individual, the production of free radicals is balanced by the antioxidant enzymes produced by the body.
Some researchers suggested that an unhealthy diet may also induce overexpression of free radicals through a number of mechanisms.
Dr. Vial G, the lead scientist said, "A high-fat diet results in both a decrease in mitochondrial quinone pool and a profound modification in mitochondrial lipid composition" and, "These changes appear to play a key role in the resulting inhibition of fatty acid oxidation and of mitochondrial oxidative-phosphorylation associated with an increased mitochondrial ROS production".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural free radical scavenger evaluated the scavenging capacity against the most physiologically relevant reactive oxygen species (ROS) and reactive nitrogen species (RNS) of 3 artichoke extract from the leaves.
According to the tested assays, all extracts of artichoke leaves processed a remarkable capacity to scavenge ROS and RNS with IC50 values in a low μg/mL range (3.4-43μg/mL).
In HUVEC cells, preincubation of HUVEC cells with the artichoke extract at concentrations of 25-100 microg/mL for 24 h showed the complete inhibition of ROS generation induced by LPS which process biological effects on hosts infected with Gram-negative bacteria.
Where HUVEC cells are normally used for the study of the function and pathology of endothelial cells derived from the endothelium of veins from the umbilical cord.
Injection of the extracts also inhibited the lipid peroxidation in the tested HUVEC cells.
Artichoke also reduced the cell apoptosis caused by free radicals damage by inhibiting the ROS generation and reducing the function of cytochrome c, a component of the electron transport chain in mitochondria in triggering programmed cell death through apoptosis.
Taken altogether, artichoke may be considered a free radical scavenger for the prevention and treatment of diseases associated with oxidative stress, pending to the result of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Infusion, decoction and hydroalcoholic extracts of leaves from artichoke (Cynaracardunculus L. subsp. cardunculus) are effective scavengers of physiologically relevant ROS and RNS by Pistón M1, Machado I1, Branco CS2, Cesio V3, Heinzen H3, Ribeiro D4, Fernandes E4, Chisté RC5, Freitas M. (PubMed)
(2) The effect of artichoke (Cynara scolymus L.) extract on ROS generation in HUVEC cells by Juzyszyn Z1, Czerny B, Pawlik A, Droździk M. (PubMed)
(3) Effects of a high-fat diet on energy metabolism and ROS production in rat liver by Vial G1, Dubouchaud H, Couturier K, Cottet-Rousselle C, Taleux N, Athias A, Galinier A, Casteilla L, Leverve XM. (PubMed)
Reactive oxygen species (ROS) or free radicals are highly reactive chemical species containing oxygen molecules. In other words, free radicals are unstable atoms with an unpaired electron in the outer ring.
Therefore, in order to become stable, free radicals must either donate or steal an electron from other atoms, leading to a chain reaction that can not be stopped until all electrons are paired or inhibited by antioxidants.
Believe it or not, free radicals in moderate amounts are needed for our body for cell signaling and activation of several transcriptional factors, apoptosis, immunity, and differentiation. However, overexpression of free radicles can cause damage to protein, lipid and cell alternation, leading a number of chronic illness, including cancer.
Free radicals are generated as metabolic by-products by biological systems. Environmental stressors (i.e., the air we breathe, UV, ionizing radiations, pollutants, and heavy metals) and xenochemicals are also found to contribute to the great increase of ROS production.
In a healthy individual, the production of free radicals is balanced by the antioxidant enzymes produced by the body.
Some researchers suggested that an unhealthy diet may also induce overexpression of free radicals through a number of mechanisms.
Dr. Vial G, the lead scientist said, "A high-fat diet results in both a decrease in mitochondrial quinone pool and a profound modification in mitochondrial lipid composition" and, "These changes appear to play a key role in the resulting inhibition of fatty acid oxidation and of mitochondrial oxidative-phosphorylation associated with an increased mitochondrial ROS production".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural free radical scavenger evaluated the scavenging capacity against the most physiologically relevant reactive oxygen species (ROS) and reactive nitrogen species (RNS) of 3 artichoke extract from the leaves.
According to the tested assays, all extracts of artichoke leaves processed a remarkable capacity to scavenge ROS and RNS with IC50 values in a low μg/mL range (3.4-43μg/mL).
In HUVEC cells, preincubation of HUVEC cells with the artichoke extract at concentrations of 25-100 microg/mL for 24 h showed the complete inhibition of ROS generation induced by LPS which process biological effects on hosts infected with Gram-negative bacteria.
Where HUVEC cells are normally used for the study of the function and pathology of endothelial cells derived from the endothelium of veins from the umbilical cord.
Injection of the extracts also inhibited the lipid peroxidation in the tested HUVEC cells.
Artichoke also reduced the cell apoptosis caused by free radicals damage by inhibiting the ROS generation and reducing the function of cytochrome c, a component of the electron transport chain in mitochondria in triggering programmed cell death through apoptosis.
Taken altogether, artichoke may be considered a free radical scavenger for the prevention and treatment of diseases associated with oxidative stress, pending to the result of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Infusion, decoction and hydroalcoholic extracts of leaves from artichoke (Cynaracardunculus L. subsp. cardunculus) are effective scavengers of physiologically relevant ROS and RNS by Pistón M1, Machado I1, Branco CS2, Cesio V3, Heinzen H3, Ribeiro D4, Fernandes E4, Chisté RC5, Freitas M. (PubMed)
(2) The effect of artichoke (Cynara scolymus L.) extract on ROS generation in HUVEC cells by Juzyszyn Z1, Czerny B, Pawlik A, Droździk M. (PubMed)
(3) Effects of a high-fat diet on energy metabolism and ROS production in rat liver by Vial G1, Dubouchaud H, Couturier K, Cottet-Rousselle C, Taleux N, Athias A, Galinier A, Casteilla L, Leverve XM. (PubMed)
Sunday, April 28, 2019
Bilberry Protects the Lung Cells Integrity and Viability Against Lung Cancer, Scientists Say
Lung cancer is a chronic condition characterized by cell growth irregularly and disorderly in the lung tissue.
Most cases of lung cancer caused by the alternation of calls DNA begin in the cells on the surface of the inner lining of the lung.
At the advanced stage, the cancer cell from the lung can travel a distance away to infect other healthy tissue and organs through the circulation of fluid and blood, leading to the secondary metastasis.
According to statistics, in 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Also in 2017, lung cancer caused the death of 21,100 Canadians.
Smoking although is a major cause of lung cancer, however, not all lung cancer patients with lung cancer are smokers. Nonsmokers lung cancer may be caused by exposure to radon, secondhand smoke, air pollution, or other factors.
Some researchers suggested that lung cancer in many incidences are associated with oxidative stress as found in advanced lung cancer patients.
Dr. the lead scientist in the examination of the oxidative stress in the risk lung cancer said, "Oxidative stress also plays important roles in the pathogenesis of many diseases, including aging, degenerative disease, and cancer. Among cancers, lung cancer is the leading cause of cancer in the Western world".
And, "Distinct measures of primary and secondary prevention have been investigated to reduce the risk of morbidity and mortality caused by lung cancer. Among them, it seems that physical activity and nutrition have some beneficial effects".
The results clearly suggested that the external sources of dietary antioxidants from the food sources may be helpful in reducing the risk of lung cancer through suppressing the overexpression of free radicals before they can induce oxidative stress.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a replacement for the treatment of lung cancer with no side effects examined the berries' bioactive compound anthocyanidins and its derivative cyanidin, malvidin, peonidin, petunidin, and delphinidin anticancer effects.
A mixture, including blueberry, bilberry and Indian blackberry ('Jamun') was selected to test in two aggressive non-small-cell lung cancer cell lines.
Injection of the mixture exerted a higher induction of cell-cycle arrest, apoptosis, and suppression of NSCLC cell invasion and migration compared to individual anthocyanidins.
According to tested assays, the mixture inhibited lung cancer cells apoptosis by decreasing the expression of the genes associated with cells cycle division and cell survival and proliferation.
Futhermore, the mixture also elevated the protein involved in cancer cell death programming.
Interestingly, in vivo, both the mixture of anthocyanidins from bilberry (0.5mg/mouse) and the most potent anthocyanidin, delphinidin (1.5mg/mouse) significantly inhibited the growth of H1299 xenografts in nude mice by 60%.
Dr. Kausar H and colleagues said, in the final report "Our results thus demonstrate the therapeutic potential of berries rich in this mixture of diverse anthocyanidins for non-small-cell lung cancer treatment and to prevent its future recurrence and metastasis".
In order to reveal more information about bilberry anti-lung cancer activity, researchers assessed the involvement of oxidative stress in lung adenocarcinogenesis, using mice deficient in the 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene and wild-type mice (C57BL6/J origin) administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Where deficiency of 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene was found to associate with the advanced stage of cancer.
On week after induced lung cancer by administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), selected mice were treated with one of 4 antioxidants (phenyl N-tert-butyl nitrone 0.13% in drinking water, resveratrol 20 ppm in the diet, lactoferrin 2% in diet and bilberry powder 2% in diet) or no supplement for 33 weeks.
All antioxidant application demonstrated a strong inhibition against lung adenocarcinogenesis, through modulating the gene expression of gene deficiency such as 8-hydroxyguanine DNA glycosylase 1 (Ogg1) and genes mutation such as Egfr and K-ras.
Taken altogether, bilberry processed abundantly bioactive compounds me be considered a functional remedy for the prevention and treatment of lung cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells by Kausar H1, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh IP, Gupta RC. (PubMed)
(2) Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice by Igarashi M1, Watanabe M, Yoshida M, Sugaya K, Endo Y, Miyajima N, Abe M, Sugano S, Nakae D.(PubMed)
(3) Lung cancer: what are the links with oxidative stress, physical activity and nutrition by Filaire E1, Dupuis C, Galvaing G, Aubreton S, Laurent H, Richard R, Filaire M. (PubMed)
Most cases of lung cancer caused by the alternation of calls DNA begin in the cells on the surface of the inner lining of the lung.
At the advanced stage, the cancer cell from the lung can travel a distance away to infect other healthy tissue and organs through the circulation of fluid and blood, leading to the secondary metastasis.
According to statistics, in 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Also in 2017, lung cancer caused the death of 21,100 Canadians.
Smoking although is a major cause of lung cancer, however, not all lung cancer patients with lung cancer are smokers. Nonsmokers lung cancer may be caused by exposure to radon, secondhand smoke, air pollution, or other factors.
Some researchers suggested that lung cancer in many incidences are associated with oxidative stress as found in advanced lung cancer patients.
Dr. the lead scientist in the examination of the oxidative stress in the risk lung cancer said, "Oxidative stress also plays important roles in the pathogenesis of many diseases, including aging, degenerative disease, and cancer. Among cancers, lung cancer is the leading cause of cancer in the Western world".
And, "Distinct measures of primary and secondary prevention have been investigated to reduce the risk of morbidity and mortality caused by lung cancer. Among them, it seems that physical activity and nutrition have some beneficial effects".
The results clearly suggested that the external sources of dietary antioxidants from the food sources may be helpful in reducing the risk of lung cancer through suppressing the overexpression of free radicals before they can induce oxidative stress.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a replacement for the treatment of lung cancer with no side effects examined the berries' bioactive compound anthocyanidins and its derivative cyanidin, malvidin, peonidin, petunidin, and delphinidin anticancer effects.
A mixture, including blueberry, bilberry and Indian blackberry ('Jamun') was selected to test in two aggressive non-small-cell lung cancer cell lines.
Injection of the mixture exerted a higher induction of cell-cycle arrest, apoptosis, and suppression of NSCLC cell invasion and migration compared to individual anthocyanidins.
According to tested assays, the mixture inhibited lung cancer cells apoptosis by decreasing the expression of the genes associated with cells cycle division and cell survival and proliferation.
Futhermore, the mixture also elevated the protein involved in cancer cell death programming.
Interestingly, in vivo, both the mixture of anthocyanidins from bilberry (0.5mg/mouse) and the most potent anthocyanidin, delphinidin (1.5mg/mouse) significantly inhibited the growth of H1299 xenografts in nude mice by 60%.
Dr. Kausar H and colleagues said, in the final report "Our results thus demonstrate the therapeutic potential of berries rich in this mixture of diverse anthocyanidins for non-small-cell lung cancer treatment and to prevent its future recurrence and metastasis".
In order to reveal more information about bilberry anti-lung cancer activity, researchers assessed the involvement of oxidative stress in lung adenocarcinogenesis, using mice deficient in the 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene and wild-type mice (C57BL6/J origin) administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Where deficiency of 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene was found to associate with the advanced stage of cancer.
On week after induced lung cancer by administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), selected mice were treated with one of 4 antioxidants (phenyl N-tert-butyl nitrone 0.13% in drinking water, resveratrol 20 ppm in the diet, lactoferrin 2% in diet and bilberry powder 2% in diet) or no supplement for 33 weeks.
All antioxidant application demonstrated a strong inhibition against lung adenocarcinogenesis, through modulating the gene expression of gene deficiency such as 8-hydroxyguanine DNA glycosylase 1 (Ogg1) and genes mutation such as Egfr and K-ras.
Taken altogether, bilberry processed abundantly bioactive compounds me be considered a functional remedy for the prevention and treatment of lung cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells by Kausar H1, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh IP, Gupta RC. (PubMed)
(2) Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice by Igarashi M1, Watanabe M, Yoshida M, Sugaya K, Endo Y, Miyajima N, Abe M, Sugano S, Nakae D.(PubMed)
(3) Lung cancer: what are the links with oxidative stress, physical activity and nutrition by Filaire E1, Dupuis C, Galvaing G, Aubreton S, Laurent H, Richard R, Filaire M. (PubMed)
Phytochemical Sinigrin Speeds Up Wound Healing
Wound healing is a natural process of immune systematic response to protect our body against the harmful pathogenic invasion.
After receiving the message from the neurons in the brain, the immune first line of defense including the macrophages stimulating the blood palettes to the site of infection to cover the injury and production of pro-inflammatory cytokines to kill off the stimuli and pathogens which try to enter the body through the wound.
Some anti-inflammatory cytokines under normal condition also switch to pro-inflammatory cytokines depending on the severity of the injury.
In some cases, overproduction of pro-inflammatory cytokines can cause damage or death of the nearby cells, leading to the formation of irreversible scars, such as hepatitis infection.
Even worse, if the immune system can not kill off all pathogens in the acute phase of infection, it will compromise to the new change, leading to chronic low-grade inflammation.
Bacterial pathogens often cause infection in specific areas of the body by overgrowth the numbers of bacteria in the site, including the gut.
According to the epidemiological studies, some bacteria are opportunistic pathogens, people with a weakened immune system are particularly prone to their invasion.
Dr. Dennis W. Metzger, the lead scientist wrote, " While it has been commonly thought that viral-induced epithelial cell damage allows bacterial invasiveness, recent studies by several groups have now implicated dysfunctional innate immune defenses following influenza as the primary culprit for enhanced susceptibility to secondary bacterial infections".
The results strongly indicated the increased risk of bacterial infection in people with a weakened immune system.
Researchers on finding a natural compound for speeding up wound healing explored on wound healing effect of sinigrin on HaCaT cells.
In the phytosome with sinigrin with an average particle size of 153 ± 39 nm, the zeta potential of 10.09 ± 0.98 mV and complex efficiency of 69.5 ± 5%.
The formulated sinigrin-phytosome complex significantly exhibited a greater wound healing effect compared to the use of sinigrin alone.
Compared to only 71% wound closer of sinigrin after 42 hours, the phytosome complex completely healed the wound.
At a lower concentration of 0.07 mg/mL, the sinigrin–phytosome complex displayed 79%, whilst sinigrin showed only 50% of wound closure.
At the higher concentration 0.14 mg/mL the sinigrin–phytosome complex completely cured the wound (100%), compared to only 71% wound healing of sinigrin.
Furthermore, The sinigrin-phytosome complex displayed minimal toxicity towards HaCaT cells.
Injection of the complex also exerted a strong effect towards A-375, a human melanoma cell line.
Dr. Mazumder A, after taking into account of co and confounders wrote at the end of the experiment, " sinigrin-phytosome complex augmented the therapeutic potential of sinigrin towards the wound healing activity".
Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for speedup wound healing, pending to the confirmation of large sample size and multicenter human study.
However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)
(2) In vitro wound healing and cytotoxic effects of sinigrin-phytosome complex by Mazumder A1, Dwivedi A1, du Preez JL1, du Plessis J2.(Pubmed)
(3) Immune Dysfunction and Bacterial Co-Infections following Influenza by Dennis W. Metzger and Keer Sun. (PMC)
After receiving the message from the neurons in the brain, the immune first line of defense including the macrophages stimulating the blood palettes to the site of infection to cover the injury and production of pro-inflammatory cytokines to kill off the stimuli and pathogens which try to enter the body through the wound.
Some anti-inflammatory cytokines under normal condition also switch to pro-inflammatory cytokines depending on the severity of the injury.
In some cases, overproduction of pro-inflammatory cytokines can cause damage or death of the nearby cells, leading to the formation of irreversible scars, such as hepatitis infection.
Even worse, if the immune system can not kill off all pathogens in the acute phase of infection, it will compromise to the new change, leading to chronic low-grade inflammation.
Bacterial pathogens often cause infection in specific areas of the body by overgrowth the numbers of bacteria in the site, including the gut.
According to the epidemiological studies, some bacteria are opportunistic pathogens, people with a weakened immune system are particularly prone to their invasion.
Dr. Dennis W. Metzger, the lead scientist wrote, " While it has been commonly thought that viral-induced epithelial cell damage allows bacterial invasiveness, recent studies by several groups have now implicated dysfunctional innate immune defenses following influenza as the primary culprit for enhanced susceptibility to secondary bacterial infections".
The results strongly indicated the increased risk of bacterial infection in people with a weakened immune system.
Researchers on finding a natural compound for speeding up wound healing explored on wound healing effect of sinigrin on HaCaT cells.
In the phytosome with sinigrin with an average particle size of 153 ± 39 nm, the zeta potential of 10.09 ± 0.98 mV and complex efficiency of 69.5 ± 5%.
The formulated sinigrin-phytosome complex significantly exhibited a greater wound healing effect compared to the use of sinigrin alone.
Compared to only 71% wound closer of sinigrin after 42 hours, the phytosome complex completely healed the wound.
At a lower concentration of 0.07 mg/mL, the sinigrin–phytosome complex displayed 79%, whilst sinigrin showed only 50% of wound closure.
At the higher concentration 0.14 mg/mL the sinigrin–phytosome complex completely cured the wound (100%), compared to only 71% wound healing of sinigrin.
Furthermore, The sinigrin-phytosome complex displayed minimal toxicity towards HaCaT cells.
Injection of the complex also exerted a strong effect towards A-375, a human melanoma cell line.
Dr. Mazumder A, after taking into account of co and confounders wrote at the end of the experiment, " sinigrin-phytosome complex augmented the therapeutic potential of sinigrin towards the wound healing activity".
Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for speedup wound healing, pending to the confirmation of large sample size and multicenter human study.
However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)
(2) In vitro wound healing and cytotoxic effects of sinigrin-phytosome complex by Mazumder A1, Dwivedi A1, du Preez JL1, du Plessis J2.(Pubmed)
(3) Immune Dysfunction and Bacterial Co-Infections following Influenza by Dennis W. Metzger and Keer Sun. (PMC)
Saturday, April 27, 2019
Whole Food Honey, the Herbal Remedy Which Suppresses Osteoarthritis
On seeking natural therapy with no side effects, scientists may have a herbal remedy for the prevention and treatment of osteoarthritis, according to studies.
Osteoarthritis (OA) is a common chronic inflammatory joint disease characterized by the breaking down of joint cartilage and the underlying bone.
Genetic preposition, overweight, and obesity, injury, and overuse of the joints are the most common risk factor associated with the onset of the disease.
Occupation with the repetitive movements of the joint is most affected by the disease.
Interestingly, osteoarthritis symptoms can come and go throughout the day and vary from person to person. Weather change has been one of the most complaints that trigger the symptoms of OA in the elderly.
Most common symptoms, according to epidemiological studies include joint pain, tenderness, and lack of flexibility and stiffness.
Some osteoporotic patient may also experience symptoms of grating sensation and bone spurs.
If you experience some of the above symptoms, you may have osteoarthritis.
Some researchers suggested that obesity may be one of the major risk factors besides the occupation with repetitive movement of osteoarthritis in the Western world.
Dr. Lauren K. King, the lead scientists in the investigation of obesity & osteoarthritis, wrote, "The most significant impact of obesity on the musculoskeletal system is associated with osteoarthritis (OA), a disabling degenerative joint disorder characterized by pain, decreased mobility and negative impact on quality of life".
And, "Obesity is associated with the incidence and progression of OA of both weight-bearing and non-weight-bearing joints, to rate of joint replacements as well as operative complications".
The finding strongly indicated the risk of osteoarthritis is increased by many folds in the obese population, compared to those with a healthy weight.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the concerns of widespread osteoarthritis (OA), a chronic degenerative joint disease, researchers investigated chrysin, a natural flavonoid extracted from honey and propolis anti-inflammatory effects.
The study included human OA chondrocytes pretreated with chrysin (1, 5, 10 μM) for 2 h and subsequently stimulated with IL-1β, an inflammatory cytokine for 24 h.
Injection of chrysin exerted a strong inhibition activity against the degradation of aggrecan and collagen-II.
Chrysin significantly inhibited the IL-1β-induced production inflammatory cytokines such as degradation of c of NO and PGE2; expression of COX-2, iNOS.
Futhermore, chrysin also reduced the expression of matrixes such as MMP-1, MMP-3, MMP-13 and enzymes ADAMTS-4, and ADAMTS-5 associated with the progression and destruction of joint in early osteoarthritis.
In the depth analysis researchers also found that chrysin dramatically blocked IL-1β-stimulated IκB-α degradation in the activation of protein NF-κB-induced production of proinflammatory cytokines.
The results suggested that chrysin inhibits the progression of OA through several mechanisms, including enzymes and proteins involving the destruction of joint tissues.
Taken altogether, honey processed a bioactive compound chrysin may be considered a functional remedy for the prevention and treatment of OA, with no side effects, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chrysin Attenuates IL-1β-Induced Expression of Inflammatory Mediators by Suppressing NF-κB in Human Osteoarthritis Chondrocytes by Zheng W1, Tao Z1, Cai L1, Chen C1, Zhang C1, Wang Q1, Ying X1, Hu W1, Chen H2. (PubMed)
(2) Obesity & osteoarthritis by Lauren K. King,* Lyn March,** and Ananthila Anandacoomarasamy. (PMC)
Osteoarthritis (OA) is a common chronic inflammatory joint disease characterized by the breaking down of joint cartilage and the underlying bone.
Genetic preposition, overweight, and obesity, injury, and overuse of the joints are the most common risk factor associated with the onset of the disease.
Occupation with the repetitive movements of the joint is most affected by the disease.
Interestingly, osteoarthritis symptoms can come and go throughout the day and vary from person to person. Weather change has been one of the most complaints that trigger the symptoms of OA in the elderly.
Most common symptoms, according to epidemiological studies include joint pain, tenderness, and lack of flexibility and stiffness.
Some osteoporotic patient may also experience symptoms of grating sensation and bone spurs.
If you experience some of the above symptoms, you may have osteoarthritis.
Some researchers suggested that obesity may be one of the major risk factors besides the occupation with repetitive movement of osteoarthritis in the Western world.
Dr. Lauren K. King, the lead scientists in the investigation of obesity & osteoarthritis, wrote, "The most significant impact of obesity on the musculoskeletal system is associated with osteoarthritis (OA), a disabling degenerative joint disorder characterized by pain, decreased mobility and negative impact on quality of life".
And, "Obesity is associated with the incidence and progression of OA of both weight-bearing and non-weight-bearing joints, to rate of joint replacements as well as operative complications".
The finding strongly indicated the risk of osteoarthritis is increased by many folds in the obese population, compared to those with a healthy weight.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the concerns of widespread osteoarthritis (OA), a chronic degenerative joint disease, researchers investigated chrysin, a natural flavonoid extracted from honey and propolis anti-inflammatory effects.
The study included human OA chondrocytes pretreated with chrysin (1, 5, 10 μM) for 2 h and subsequently stimulated with IL-1β, an inflammatory cytokine for 24 h.
Injection of chrysin exerted a strong inhibition activity against the degradation of aggrecan and collagen-II.
Chrysin significantly inhibited the IL-1β-induced production inflammatory cytokines such as degradation of c of NO and PGE2; expression of COX-2, iNOS.
Futhermore, chrysin also reduced the expression of matrixes such as MMP-1, MMP-3, MMP-13 and enzymes ADAMTS-4, and ADAMTS-5 associated with the progression and destruction of joint in early osteoarthritis.
In the depth analysis researchers also found that chrysin dramatically blocked IL-1β-stimulated IκB-α degradation in the activation of protein NF-κB-induced production of proinflammatory cytokines.
The results suggested that chrysin inhibits the progression of OA through several mechanisms, including enzymes and proteins involving the destruction of joint tissues.
Taken altogether, honey processed a bioactive compound chrysin may be considered a functional remedy for the prevention and treatment of OA, with no side effects, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chrysin Attenuates IL-1β-Induced Expression of Inflammatory Mediators by Suppressing NF-κB in Human Osteoarthritis Chondrocytes by Zheng W1, Tao Z1, Cai L1, Chen C1, Zhang C1, Wang Q1, Ying X1, Hu W1, Chen H2. (PubMed)
(2) Obesity & osteoarthritis by Lauren K. King,* Lyn March,** and Ananthila Anandacoomarasamy. (PMC)
Bilberry Inhibits the Risk and Progression of Colon Cancer, According to Researchers
Colon cancer is a medical and chronic condition characterized by the growth of the cells disorderly and uncontrollably in the colon tissue.
Most cases of colon cancers begin in the cells on the surface of the inner lining due to the alternation of DNA.
Colon cancer is one most slow growing cancer. It may take years before patients experiencing the symptoms.
At the later stage, the larger size of the tumor may suppress the nearby blood vessels and nerve cells, leading to localized severe pain and bleeding.
Most common symptoms of colon cancer in the advanced stage, besides the general symptom of cancer such as reduced appetite, unintended weight loss include a change of bowel movement, rectal bleeding, and persistent abdominal pain and cramp.
If you experience some of the above symptoms, please check with your doctor to rule out the possibility of colon cancer.
According to the statistics, in 2017, approximately 26,800 Canadians were diagnosed with colorectal cancer, representing 13% of all new cancer cases.
Depending on the stage, early diagnosis of localized colon cancer has a 5-year relative survival rate of over 90%.
Out of a number of the risk factors, obesity may be one which causes the majority of colon cancer in the Western world, particularly in the North American.
Dr. E E Frezza, the lead scientist in the assessment of obesity on the risk of developing colon cancer, said, "Visceral abdominal fat has been identified as the essential fat depot for pathogenetic theories that relate obesity and colon cancer".
And, "Obesity imposes a greater risk of colon cancer for men of all ages and for premenopausal women than it does for postmenopausal women. Regular exercise reduces the risk of developing colon cancer and the risk of death from colon cancer should it develop. We believe that a combination of waist circumference (WC) and body mass index (BMI) measurements is recommended to assess the obesity-related risk of developing colon cancer".
The results suggested that if you are obese, your risk of colon cancer is increased much fold compared to healthy weight individual.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compounf for the treatment of colon cancer examined the bilberry derived anthocyanins chemopreventive properties.
The study included 50 female Balb/c mice induced colonic carcinogenesis by AOM and DSS 3 or 5%, respectively, Mice then are given either normal food (controls) or a diet containing either 10 or 1% anthocyanin-rich bilberry extract.
According to the colonoscopy taken place at week 4 and 9 after initiation of carcinogenesis, mice receiving 10% anthocyanins showed significantly (p < 0.004) less reduced colon length (12.1 cm [8.5-14.4 cm]) as compared to controls (11.2 cm [9.8-12.3]) indicating less inflammation.
Furthermore, mice fed with 10% anthocyanin-rich extract revealed significantly less mean tumor numbers, compared to control (n = 14) and anthocyanin 1% treated mice.
The results suggested that anthocyanins inhibited the formation and growth of colorectal cancer in an animal model.
In order to reveal more information about anthocyanins anti-colon cancer activity, researchers examined the compound on human colon and colorectal cancer cells (DLD-1 and COLO205).
Using the optimum process of A(V.uli) extraction involved conditions of temperature 20°C, pH 2.0, and diatomaceous earth 1.0 g/50 g of fruit weight. A(V.uli), 5 main components: delphinidin (40.70 ± 1.72)%, cyanidin (3.40 ± 0.68)%, petunidin (17.70 ± 0.54)%, peonidin (2.90 ± 0.63)% and malvidin (35.50 ± 1.11)% were found in the anthocyanins extract.
Malvidin, the derivatives found in the extracts exerted the strongest anti-colon cancer cell properties with dose-dependent repression of cancer cell proliferation with an IC(50) (50% inhibitory concentration) value of 50 µg/ml, compared to other derovatives.
Dr. Zu XY and colleagues wrote in the final report, "The extraction protocol and conditions we used were effective for anthocyanin extraction. A(V.uli) could be a feasible practical research tool and a promising therapeutic source to suppress human colon or colorectal cancers".
Taken altogether, bilberry processed abundantly bioactive compounds anthocyanin and malvidin may be considered a functional remedy for the prevention and treatment of colon cancer, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model by Lippert E1, Ruemmele P, Obermeier F, Goelder S, Kunst C, Rogler G, Dunger N, Messmann H, Hartmann A, Endlicher E. (PubMed)
(2) Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells by Zu XY1, Zhang ZY, Zhang XW, Yoshioka M, Yang YN, Li J. (PubMed)
(3) Influence of obesity on the risk of developing colon cancer by E E Frezza, M S Wachtel, and M Chiriva‐Internati. (PMC)
Most cases of colon cancers begin in the cells on the surface of the inner lining due to the alternation of DNA.
Colon cancer is one most slow growing cancer. It may take years before patients experiencing the symptoms.
At the later stage, the larger size of the tumor may suppress the nearby blood vessels and nerve cells, leading to localized severe pain and bleeding.
Most common symptoms of colon cancer in the advanced stage, besides the general symptom of cancer such as reduced appetite, unintended weight loss include a change of bowel movement, rectal bleeding, and persistent abdominal pain and cramp.
If you experience some of the above symptoms, please check with your doctor to rule out the possibility of colon cancer.
According to the statistics, in 2017, approximately 26,800 Canadians were diagnosed with colorectal cancer, representing 13% of all new cancer cases.
Depending on the stage, early diagnosis of localized colon cancer has a 5-year relative survival rate of over 90%.
Out of a number of the risk factors, obesity may be one which causes the majority of colon cancer in the Western world, particularly in the North American.
Dr. E E Frezza, the lead scientist in the assessment of obesity on the risk of developing colon cancer, said, "Visceral abdominal fat has been identified as the essential fat depot for pathogenetic theories that relate obesity and colon cancer".
And, "Obesity imposes a greater risk of colon cancer for men of all ages and for premenopausal women than it does for postmenopausal women. Regular exercise reduces the risk of developing colon cancer and the risk of death from colon cancer should it develop. We believe that a combination of waist circumference (WC) and body mass index (BMI) measurements is recommended to assess the obesity-related risk of developing colon cancer".
The results suggested that if you are obese, your risk of colon cancer is increased much fold compared to healthy weight individual.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compounf for the treatment of colon cancer examined the bilberry derived anthocyanins chemopreventive properties.
The study included 50 female Balb/c mice induced colonic carcinogenesis by AOM and DSS 3 or 5%, respectively, Mice then are given either normal food (controls) or a diet containing either 10 or 1% anthocyanin-rich bilberry extract.
According to the colonoscopy taken place at week 4 and 9 after initiation of carcinogenesis, mice receiving 10% anthocyanins showed significantly (p < 0.004) less reduced colon length (12.1 cm [8.5-14.4 cm]) as compared to controls (11.2 cm [9.8-12.3]) indicating less inflammation.
Furthermore, mice fed with 10% anthocyanin-rich extract revealed significantly less mean tumor numbers, compared to control (n = 14) and anthocyanin 1% treated mice.
The results suggested that anthocyanins inhibited the formation and growth of colorectal cancer in an animal model.
In order to reveal more information about anthocyanins anti-colon cancer activity, researchers examined the compound on human colon and colorectal cancer cells (DLD-1 and COLO205).
Using the optimum process of A(V.uli) extraction involved conditions of temperature 20°C, pH 2.0, and diatomaceous earth 1.0 g/50 g of fruit weight. A(V.uli), 5 main components: delphinidin (40.70 ± 1.72)%, cyanidin (3.40 ± 0.68)%, petunidin (17.70 ± 0.54)%, peonidin (2.90 ± 0.63)% and malvidin (35.50 ± 1.11)% were found in the anthocyanins extract.
Malvidin, the derivatives found in the extracts exerted the strongest anti-colon cancer cell properties with dose-dependent repression of cancer cell proliferation with an IC(50) (50% inhibitory concentration) value of 50 µg/ml, compared to other derovatives.
Dr. Zu XY and colleagues wrote in the final report, "The extraction protocol and conditions we used were effective for anthocyanin extraction. A(V.uli) could be a feasible practical research tool and a promising therapeutic source to suppress human colon or colorectal cancers".
Taken altogether, bilberry processed abundantly bioactive compounds anthocyanin and malvidin may be considered a functional remedy for the prevention and treatment of colon cancer, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model by Lippert E1, Ruemmele P, Obermeier F, Goelder S, Kunst C, Rogler G, Dunger N, Messmann H, Hartmann A, Endlicher E. (PubMed)
(2) Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells by Zu XY1, Zhang ZY, Zhang XW, Yoshioka M, Yang YN, Li J. (PubMed)
(3) Influence of obesity on the risk of developing colon cancer by E E Frezza, M S Wachtel, and M Chiriva‐Internati. (PMC)
Friday, April 26, 2019
Herbal Artichoke Inhibits the Risk and Progression of Hepatic (Liver) Fibrosis, Researchers Reveal
Artichoke may be used as a natural remedy for the treatment of hepatic fibrosis with no side effects, according to studies.
Hepatic fibrosis is a chronic liver disease due to liver scars overwhelmingly building up in the connective tissue in the liver.
The severe case of hepatic fibrosis can lead to cirrhosis, affecting the liver function in filtering the blood. In the US, over 4.5 million people are affected by liver cirrhosis, leading to the death 12/100,000 of the population every year.
Most common causes of liver fibrosis are excessive alcohol drinking and infected by the hepatitis virus.
Other risk factors associated with the prevalent risk liver fibrosis are non-alcoholic steatohepatitis and autoimmune liver disease, including autoimmune hepatitis, primary biliary cirrhosis or primary sclerosing cholangitis.
However, the increase in age may also have a strong implication on the disease onset.
Dr. Bénédicte Delire, the lead scientists, in the concern of liver fibrosis in the aging mice population said, "Old mice developed more severe fibrosis compared to young ones as evaluated by Sirius red morphometry" and " While fibrosis resolution occurred in young mice within 96 hours, no significant fibrosis attenuation was observed in old mice".
"Although recruitment of monocytes-derived macrophages was similar in young and old livers, young macrophages had globally a remodeling phenotype while old ones, a pro-fibrogenic phenotype".
The results suggested that the elderly are associated with the more severe fibrosis, due to the weakened immune system
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of hepatic fibrosis, before the excessive connective tissue builds up in the liver progressing to chronic liver diseases such as cirrhosis and liver cancer examined the liver protective effect of artichoke against the liver fibrosis.
The study included 12 groups of rats were administered JAT, interferon, and ribavirin either separately or in combination from day one of CCL4 administration until the end of the study.
Observation of the killed animals after 8 weeks, CCL4- induced hepatotoxicity exerted a significant increase level of hepatic protein expression levels associated with cell cycle arrest through the function of tumor suppressive activity.
Furthermore, the levels of enzymes and protein associated with cell apoptosis such as p53, BAX, and TGF-β also were also increased in CCL-4 induced hepatotoxic rat group.
Injection JAT rats not only exerted a strong effect in normalizing the function of proteins and enzymes in the induction of liver cell death but also improved the liver response to ribavirin and interferon used for the treatment of HCV infection.
Dr. Abdel-Hamid NM and colleagues in the final report wrote, "addition of JAT as a supportive regimen to interferon and ribavirin effectively potentiates their anti-fibrotic effects".
Moreover, the observation of four mice groups infected with parasite S. mansoni with the first three groups received ALE, ALE + PZQ and PZQ respectively compared to the 4th and 5th group acted as the positive control and negative control, respectively suggested that ALE caused significant reduction of granuloma diameter, improvement of liver functions and liver fibrosis.
The efficacy of ALE was attributed to the increase the hepatic stellate cells (HSCs) recruitment inside granuloma associated with the liver response to infection, inflammation, or the presence of a foreign substance, and limited liver fibrosis by their inhibition in the peri- and inter-granuloma liver tissue.
However, in spite of the ALE liver protective activity against the formation of liver fibrosis and increased liver functioning, ALE showed no effect against parasite infection.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of liver fibrosis depending on the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Synergistic Effects of Jerusalem Artichoke in Combination with Pegylated Interferon Alfa-2a and Ribavirin Against Hepatic Fibrosis in Rats by Abdel-Hamid NM1, Wahid A, Nazmy MH, Eisa MA. (PubMed)
(2) Artichoke leaf extract protects liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cells recruitment by Sharaf El-Deen SA1, Brakat RM2, Mohamed ASED. (PubMed)
(3) Aging enhances liver fibrotic response in mice through hampering extracellular matrix remodeling by Bénédicte Delire,1 Valérie Lebrun,1 Charlotte Selvais,1 Patrick Henriet,2 Amélie Bertrand,1Yves Horsmans,1,3 and Isabelle A. Leclercq. (PMC)
Hepatic fibrosis is a chronic liver disease due to liver scars overwhelmingly building up in the connective tissue in the liver.
The severe case of hepatic fibrosis can lead to cirrhosis, affecting the liver function in filtering the blood. In the US, over 4.5 million people are affected by liver cirrhosis, leading to the death 12/100,000 of the population every year.
Most common causes of liver fibrosis are excessive alcohol drinking and infected by the hepatitis virus.
Other risk factors associated with the prevalent risk liver fibrosis are non-alcoholic steatohepatitis and autoimmune liver disease, including autoimmune hepatitis, primary biliary cirrhosis or primary sclerosing cholangitis.
However, the increase in age may also have a strong implication on the disease onset.
Dr. Bénédicte Delire, the lead scientists, in the concern of liver fibrosis in the aging mice population said, "Old mice developed more severe fibrosis compared to young ones as evaluated by Sirius red morphometry" and " While fibrosis resolution occurred in young mice within 96 hours, no significant fibrosis attenuation was observed in old mice".
"Although recruitment of monocytes-derived macrophages was similar in young and old livers, young macrophages had globally a remodeling phenotype while old ones, a pro-fibrogenic phenotype".
The results suggested that the elderly are associated with the more severe fibrosis, due to the weakened immune system
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of hepatic fibrosis, before the excessive connective tissue builds up in the liver progressing to chronic liver diseases such as cirrhosis and liver cancer examined the liver protective effect of artichoke against the liver fibrosis.
The study included 12 groups of rats were administered JAT, interferon, and ribavirin either separately or in combination from day one of CCL4 administration until the end of the study.
Observation of the killed animals after 8 weeks, CCL4- induced hepatotoxicity exerted a significant increase level of hepatic protein expression levels associated with cell cycle arrest through the function of tumor suppressive activity.
Furthermore, the levels of enzymes and protein associated with cell apoptosis such as p53, BAX, and TGF-β also were also increased in CCL-4 induced hepatotoxic rat group.
Injection JAT rats not only exerted a strong effect in normalizing the function of proteins and enzymes in the induction of liver cell death but also improved the liver response to ribavirin and interferon used for the treatment of HCV infection.
Dr. Abdel-Hamid NM and colleagues in the final report wrote, "addition of JAT as a supportive regimen to interferon and ribavirin effectively potentiates their anti-fibrotic effects".
Moreover, the observation of four mice groups infected with parasite S. mansoni with the first three groups received ALE, ALE + PZQ and PZQ respectively compared to the 4th and 5th group acted as the positive control and negative control, respectively suggested that ALE caused significant reduction of granuloma diameter, improvement of liver functions and liver fibrosis.
The efficacy of ALE was attributed to the increase the hepatic stellate cells (HSCs) recruitment inside granuloma associated with the liver response to infection, inflammation, or the presence of a foreign substance, and limited liver fibrosis by their inhibition in the peri- and inter-granuloma liver tissue.
However, in spite of the ALE liver protective activity against the formation of liver fibrosis and increased liver functioning, ALE showed no effect against parasite infection.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of liver fibrosis depending on the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Synergistic Effects of Jerusalem Artichoke in Combination with Pegylated Interferon Alfa-2a and Ribavirin Against Hepatic Fibrosis in Rats by Abdel-Hamid NM1, Wahid A, Nazmy MH, Eisa MA. (PubMed)
(2) Artichoke leaf extract protects liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cells recruitment by Sharaf El-Deen SA1, Brakat RM2, Mohamed ASED. (PubMed)
(3) Aging enhances liver fibrotic response in mice through hampering extracellular matrix remodeling by Bénédicte Delire,1 Valérie Lebrun,1 Charlotte Selvais,1 Patrick Henriet,2 Amélie Bertrand,1Yves Horsmans,1,3 and Isabelle A. Leclercq. (PMC)
Herbal Turmeric, the Natural Treatment for Hyperlipidemia with No Side Effects
Hyperlipidemia is a chronic condition of abnormally high levels of any or all lipoproteins in the bloodstream, including cholesterol and triglycerides.
The condition is normally known as high blood cholesterol in the general population.
People with hyperlipidemia are asymptomatic. Over time, the fat collection in the arteries accompanied by calcium or other substances form plague, leading to narrowing arteries and reduced function of the arteries to transport oxygen-rich blood to the parts of the body.
According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.
Believe it or not, about half of the U.S. adults (55%, or 43 million) are currently taking medicine associated with lower blood cholesterol.
There are many risk factors that cause the onset of hyperlipidemia, such as people with diabetes, being overweight gain, physical activity, and smoking.
Some researchers suggested the promotion of high-fat diet over past decades may be one of the silent cause of the hyperlipidemia in the Western world.
Dr. Charles Desmarchelier in the examined the risk of high blood cholesterol in a high-fat diet model said, "Mice on Western diet showed increased plasma cholesterol levels, associated with the higher dietary cholesterol supply, yet, significantly reduced cholesterol levels were found in intestine and liver".
And, "(The) intestine and liver react to a high dietary fat intake by activation of de novo cholesterol synthesis and other cholesterol-saving mechanisms, as well as with major changes in phospholipid metabolism, to accommodate to the fat load'.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural ingredient for the treatment of hyperlipidemia, researchers investigated the effects of curcumin on hyperlipidemia and hepatic steatosis in high-fructose-fed Wistar rats.
The study included 40 male Wistar rats divided into four groups with 10 rats in each. Two groups were fed with standard rodent diet and the other two with 60% high-fructose diet for 10 weeks. Curcumin (200 mg/kg body weight) was administered along with the diets simultaneously to each of the aforementioned diet groups.
After 10 weeks of the experiment, researchers found that curcumin decreased the levels of hyperlipidemia observed by reducing body weight, liver weight, adipose weight.
The plasma levels of triglyceride by inhibited the proteins associated with fat cell fat metabolism, lipid ratios and increased HDL-C (28.4 ± 4.5 mg/dL) in fructose-fed rats were also lower by the injection of curcumin.
Furthermore, curcumin also suppressed the lipogenic enzymes involved in regulating lipogenesis in fat cells.
Taken altogether, turmeric processed a high amount of curcumin may be used for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats by Maithilikarpagaselvi N1, Sridhar MG1, Swaminathan RP2, Sripradha R1, Badhe B. (PubMed)
(2) Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals by Kocher A1, Bohnert L1, Schiborr C1, Frank J, (PubMed)
(3) C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia by Charles Desmarchelier,
1 Christoph Dahlhoff,1,2 Sylvia Keller,3 Manuela Sailer,1Gerhard Jahreis,3 and Hannelore Daniel. (PMC)
The condition is normally known as high blood cholesterol in the general population.
People with hyperlipidemia are asymptomatic. Over time, the fat collection in the arteries accompanied by calcium or other substances form plague, leading to narrowing arteries and reduced function of the arteries to transport oxygen-rich blood to the parts of the body.
According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.
Believe it or not, about half of the U.S. adults (55%, or 43 million) are currently taking medicine associated with lower blood cholesterol.
There are many risk factors that cause the onset of hyperlipidemia, such as people with diabetes, being overweight gain, physical activity, and smoking.
Some researchers suggested the promotion of high-fat diet over past decades may be one of the silent cause of the hyperlipidemia in the Western world.
Dr. Charles Desmarchelier in the examined the risk of high blood cholesterol in a high-fat diet model said, "Mice on Western diet showed increased plasma cholesterol levels, associated with the higher dietary cholesterol supply, yet, significantly reduced cholesterol levels were found in intestine and liver".
And, "(The) intestine and liver react to a high dietary fat intake by activation of de novo cholesterol synthesis and other cholesterol-saving mechanisms, as well as with major changes in phospholipid metabolism, to accommodate to the fat load'.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural ingredient for the treatment of hyperlipidemia, researchers investigated the effects of curcumin on hyperlipidemia and hepatic steatosis in high-fructose-fed Wistar rats.
The study included 40 male Wistar rats divided into four groups with 10 rats in each. Two groups were fed with standard rodent diet and the other two with 60% high-fructose diet for 10 weeks. Curcumin (200 mg/kg body weight) was administered along with the diets simultaneously to each of the aforementioned diet groups.
After 10 weeks of the experiment, researchers found that curcumin decreased the levels of hyperlipidemia observed by reducing body weight, liver weight, adipose weight.
The plasma levels of triglyceride by inhibited the proteins associated with fat cell fat metabolism, lipid ratios and increased HDL-C (28.4 ± 4.5 mg/dL) in fructose-fed rats were also lower by the injection of curcumin.
Furthermore, curcumin also suppressed the lipogenic enzymes involved in regulating lipogenesis in fat cells.
Taken altogether, turmeric processed a high amount of curcumin may be used for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats by Maithilikarpagaselvi N1, Sridhar MG1, Swaminathan RP2, Sripradha R1, Badhe B. (PubMed)
(2) Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals by Kocher A1, Bohnert L1, Schiborr C1, Frank J, (PubMed)
(3) C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia by Charles Desmarchelier,
1 Christoph Dahlhoff,1,2 Sylvia Keller,3 Manuela Sailer,1Gerhard Jahreis,3 and Hannelore Daniel. (PMC)
Thursday, April 25, 2019
Phytochemical Betanin Gobbles Up Breast Cancer Cells in Vitro
Breast cancer is a chronic and medical condition characterized by cell growth irregularly in the breast tissues due to DNA alternation.
Most cases of breast cancer begin in the cell on the surface of the inner lining of the breast tissues before penetrating into the deeper layers.
According to the statistics, in the US the lifetime of breast cancer in women is 1/8. In other words, if you are women, your risk of breast cancer development during your lifetime is 12.5%.
According to the prediction using the historical data, in 2019, approximately 268,600 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S., along with 62,930 new cases of non-invasive (in situ) breast cancer.
The exact causes of breast cancer are not identified. However, according to the epidemiological studies, certain conditions may increase the risk of the disease such as being overweight, diet, inactivity, excessive alcohol consumption, smoking and exposure to xenoestrogen.
Some researchers suggested that the discovery of oral contraceptive pill over the past few decades may correlate to the rise if breast cancer.
In other words, if you currently use an oral contraceptive, you are at a higher risk of the disease onset.
Dr. Kathleen E. Malone in the examined the breast cancer risk in women who use oral contraceptives wrote, "Breast cancer incidence in Western countries is relatively high and apparently is increasing. That breast cancer appears to be influenced by other hormonally mediated factors leads to the hypothesis that the high rate of exposure to oral contraceptives among American women may also be associated with this increase".
And, "an increasing number of studies have appeared that suggest an elevated risk in relation to some aspects of oral contractive use".
Betanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential ingredient in plant phytochemicals for the treatment of breast cancer without inducing adverse effect compared to those of conventional medicine, researchers examined the extracts containing betanin and its stereoisomer isobetanin, which belongs to the betalain group of highly bioavailable antioxidants.
The study involved the analysis of the cytotoxicity of applying betanin-enriched extract then characterized on cancer and normal cells.
Betanin/isobetanin concentrate significantly decreased cancer cell proliferation and viability of MCF-7-treated cells, by inducing the production of proteins associated with proapoptosis and gene associated with tumor suppression.
Observation of the increased alternation of the mitochondrial membrane potential suggested that the extracts cause cancer cell death by both intrinsic and extrinsic apoptotic pathways.
The death of MCF-7-treated cells is also attributed to betanin/isobetanin induced autophagy.
Interestingly, injection of betanin-enriched extract showed no obvious effect towards normal cell lines.
Dr. Nowacki L, the lead scientist said, "the betanin/isobetanin mix as a therapeutic anticancer compound, alone or in combination with classical chemotherapeutic drugs, especially in functional p53 tumors".
In other words, betanin/isobetanin mix extracts processed anti-breast cancer cell proliferation by inducing cell death without affecting the integrity and viability of the normal breast cells.
In the analysis of the FDA approved red food color E162, used in suppressing the development of multi-organ tumors in experimental animals, researchers compared the cytotoxic effect of the red beetroot extract with an anticancer drug, doxorubicin (Adriamycin) in the estrogen receptor-positive human breast cancer cells (MCF-7).
Beetroot extract exerted a significantly lower cancer cell inhibition compared to that doxorubicin.
The findings suggested that betanin, the major betacyanin constituent, may play an important role in the cytotoxicity exhibited by the red beetroot extract, according to the study.
Taken altogether, betanin used alone or combined with other phytochemicals may be considered supplements for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin-Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells by Nowacki L1,2, Vigneron P2, Rotellini L2, Cazzola H1, Merlier F1, Prost E1, Ralanairina R3, Gadonna JP3, Rossi C1, Vayssade M2. (PubMed)
(2) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancercell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
(3) Oral Contraceptives and Breast Cancer: A Review of the Epidemiological Evidence with an Emphasis on Younger Women by Kathleen E. Malone. (NCBI)
Most cases of breast cancer begin in the cell on the surface of the inner lining of the breast tissues before penetrating into the deeper layers.
According to the statistics, in the US the lifetime of breast cancer in women is 1/8. In other words, if you are women, your risk of breast cancer development during your lifetime is 12.5%.
According to the prediction using the historical data, in 2019, approximately 268,600 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S., along with 62,930 new cases of non-invasive (in situ) breast cancer.
The exact causes of breast cancer are not identified. However, according to the epidemiological studies, certain conditions may increase the risk of the disease such as being overweight, diet, inactivity, excessive alcohol consumption, smoking and exposure to xenoestrogen.
Some researchers suggested that the discovery of oral contraceptive pill over the past few decades may correlate to the rise if breast cancer.
In other words, if you currently use an oral contraceptive, you are at a higher risk of the disease onset.
Dr. Kathleen E. Malone in the examined the breast cancer risk in women who use oral contraceptives wrote, "Breast cancer incidence in Western countries is relatively high and apparently is increasing. That breast cancer appears to be influenced by other hormonally mediated factors leads to the hypothesis that the high rate of exposure to oral contraceptives among American women may also be associated with this increase".
And, "an increasing number of studies have appeared that suggest an elevated risk in relation to some aspects of oral contractive use".
Betanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential ingredient in plant phytochemicals for the treatment of breast cancer without inducing adverse effect compared to those of conventional medicine, researchers examined the extracts containing betanin and its stereoisomer isobetanin, which belongs to the betalain group of highly bioavailable antioxidants.
The study involved the analysis of the cytotoxicity of applying betanin-enriched extract then characterized on cancer and normal cells.
Betanin/isobetanin concentrate significantly decreased cancer cell proliferation and viability of MCF-7-treated cells, by inducing the production of proteins associated with proapoptosis and gene associated with tumor suppression.
Observation of the increased alternation of the mitochondrial membrane potential suggested that the extracts cause cancer cell death by both intrinsic and extrinsic apoptotic pathways.
The death of MCF-7-treated cells is also attributed to betanin/isobetanin induced autophagy.
Interestingly, injection of betanin-enriched extract showed no obvious effect towards normal cell lines.
Dr. Nowacki L, the lead scientist said, "the betanin/isobetanin mix as a therapeutic anticancer compound, alone or in combination with classical chemotherapeutic drugs, especially in functional p53 tumors".
In other words, betanin/isobetanin mix extracts processed anti-breast cancer cell proliferation by inducing cell death without affecting the integrity and viability of the normal breast cells.
In the analysis of the FDA approved red food color E162, used in suppressing the development of multi-organ tumors in experimental animals, researchers compared the cytotoxic effect of the red beetroot extract with an anticancer drug, doxorubicin (Adriamycin) in the estrogen receptor-positive human breast cancer cells (MCF-7).
Beetroot extract exerted a significantly lower cancer cell inhibition compared to that doxorubicin.
The findings suggested that betanin, the major betacyanin constituent, may play an important role in the cytotoxicity exhibited by the red beetroot extract, according to the study.
Taken altogether, betanin used alone or combined with other phytochemicals may be considered supplements for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin-Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells by Nowacki L1,2, Vigneron P2, Rotellini L2, Cazzola H1, Merlier F1, Prost E1, Ralanairina R3, Gadonna JP3, Rossi C1, Vayssade M2. (PubMed)
(2) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancercell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
(3) Oral Contraceptives and Breast Cancer: A Review of the Epidemiological Evidence with an Emphasis on Younger Women by Kathleen E. Malone. (NCBI)
Herbal Artichoke Protects the Brian Neurons Against Learning and Memory Impairment
Learning is an action of acquired skill or knowledge in a short or lifelong process.
Memory is an action of storing the acquired knowledge expressed them when they are needed.
In other words, learning and memory is a process involved different stages including acquisition, consolidation, and retrieval.
There are many causes of neurons loss in facilitating the onset of learning and memory impairment. In fact, neuronal apoptosis has been reported to play a key role in the impairment of learning and memory processes.
Several toxins such as scopolamine, streptozotocin, quinolinic acid, and domoic acid have been found to utilize based on their mechanism of action for learning and memory impairment.
Toxins induced amyloid-β deposits are known to cause specific learning and memory impairment in patients with Parkinson's disease dementia and Alzheimer's disease dementia.
Environmental pollutant, such as botulinum, and lipopolysaccharide are also considered various classes of neurotoxin models for learning and memory impairment.
Although the increase in aging has been well known to be a major factor in the initiation of the learning and memory impairment in patients with neurodegenerative disease, genetic mutation also have a strong implication on cognitive functions that can lead to either impairment in learning and memory.
Dr. Niu Q, the lead scientist, in the assessment of the acquired genetic mutation in patients with learning and memory impairment said, "Neuronal apoptosis has become a focus of interest, as it has been reported to play a key role in the impairment of learning and memory processes (Thompson, Science 267:1456, 1995). The Bcl-2 gene acts as an important effector for inhibiting apoptosis".
"Neuronal apoptosis was extensive in the brain of Al-exposed groups, and the expressions of Bcl-2 protein in the frontal cortex, cerebellum, and hippocampus of Al-exposed rats was stronger... and chronic Al-exposure in rats is associated with neuronal apoptosis in the brain, and impaired learning and memory. Augmented Bcl-2 protein expression may be a stimulated compensatory mechanism".
The findings strongly suggested that gene alternation due to long-term exposure to toxic chemical cause gradual loss and death neurons, leading to learning and memory impairment.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the treatment of learning and memory impairment investigated the Stachys sieboldii (Chinese artichoke) neuroprotective effects of S. sieboldii tuber extract in alleviating learning and memory dysfunction associated with vascular dementia or Alzheimer's disease.
Ginkgo biloba leaf extract (ginkgo extract) used as a positive control. Mice were subjected to bilateral carotid artery occlusion (BCAO) for 30 min.
Oral administration of chorogi or ginkgo extracts significantly reduced post-ischemic glucose intolerance on day 1 and neuronal damage including memory impairment on day 3 after BCAO without affecting the locomotor activity.
Furthermore, both chorogi or ginkgo extract insignificantly alleviated scopolamine-induced learning and memory impairments.
In primary neurons, the neuronal survival rate was significantly reduced by hydrogen peroxide was significantly suppressed by chorogi extract and ginkgo extract.
These results suggested, chorogi or ginkgo extract protected the neurons integrity and viability by inhibiting the overexpression of free radicals through improving the antioxidant enzymes produced by the mice.
Researchers at the final report wrote. "chorogi extract, as well as ginkgo extract, can protect against learning and memory dysfunction associated with ischemic brain injury through an antioxidative mechanism".
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of p learning and memory impairment with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Stachys sieboldii (Labiatae, Chorogi) Protects against Learning and MemoryDysfunction Associated with Ischemic Brain Injury by Harada S1, Tsujita T, Ono A, Miyagi K, Mori T, Tokuyama S. (PubMed)
(2) Toxin-Induced Experimental Models of Learning and Memory Impairment by More SV1, Kumar H2, Cho DY3, Yun YS4, Choi DK. (PubMed)
(3) The relationship between Bcl-gene expression and learning and memory impairment in chronic aluminum-exposed rats by Niu Q1, Yang Y, Zhang Q, Niu P, He S, Di Gioacchino M, Conti P, Boscolo P. (PubMed)
Memory is an action of storing the acquired knowledge expressed them when they are needed.
In other words, learning and memory is a process involved different stages including acquisition, consolidation, and retrieval.
There are many causes of neurons loss in facilitating the onset of learning and memory impairment. In fact, neuronal apoptosis has been reported to play a key role in the impairment of learning and memory processes.
Several toxins such as scopolamine, streptozotocin, quinolinic acid, and domoic acid have been found to utilize based on their mechanism of action for learning and memory impairment.
Toxins induced amyloid-β deposits are known to cause specific learning and memory impairment in patients with Parkinson's disease dementia and Alzheimer's disease dementia.
Environmental pollutant, such as botulinum, and lipopolysaccharide are also considered various classes of neurotoxin models for learning and memory impairment.
Although the increase in aging has been well known to be a major factor in the initiation of the learning and memory impairment in patients with neurodegenerative disease, genetic mutation also have a strong implication on cognitive functions that can lead to either impairment in learning and memory.
Dr. Niu Q, the lead scientist, in the assessment of the acquired genetic mutation in patients with learning and memory impairment said, "Neuronal apoptosis has become a focus of interest, as it has been reported to play a key role in the impairment of learning and memory processes (Thompson, Science 267:1456, 1995). The Bcl-2 gene acts as an important effector for inhibiting apoptosis".
"Neuronal apoptosis was extensive in the brain of Al-exposed groups, and the expressions of Bcl-2 protein in the frontal cortex, cerebellum, and hippocampus of Al-exposed rats was stronger... and chronic Al-exposure in rats is associated with neuronal apoptosis in the brain, and impaired learning and memory. Augmented Bcl-2 protein expression may be a stimulated compensatory mechanism".
The findings strongly suggested that gene alternation due to long-term exposure to toxic chemical cause gradual loss and death neurons, leading to learning and memory impairment.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the treatment of learning and memory impairment investigated the Stachys sieboldii (Chinese artichoke) neuroprotective effects of S. sieboldii tuber extract in alleviating learning and memory dysfunction associated with vascular dementia or Alzheimer's disease.
Ginkgo biloba leaf extract (ginkgo extract) used as a positive control. Mice were subjected to bilateral carotid artery occlusion (BCAO) for 30 min.
Oral administration of chorogi or ginkgo extracts significantly reduced post-ischemic glucose intolerance on day 1 and neuronal damage including memory impairment on day 3 after BCAO without affecting the locomotor activity.
Furthermore, both chorogi or ginkgo extract insignificantly alleviated scopolamine-induced learning and memory impairments.
In primary neurons, the neuronal survival rate was significantly reduced by hydrogen peroxide was significantly suppressed by chorogi extract and ginkgo extract.
These results suggested, chorogi or ginkgo extract protected the neurons integrity and viability by inhibiting the overexpression of free radicals through improving the antioxidant enzymes produced by the mice.
Researchers at the final report wrote. "chorogi extract, as well as ginkgo extract, can protect against learning and memory dysfunction associated with ischemic brain injury through an antioxidative mechanism".
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of p learning and memory impairment with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Stachys sieboldii (Labiatae, Chorogi) Protects against Learning and MemoryDysfunction Associated with Ischemic Brain Injury by Harada S1, Tsujita T, Ono A, Miyagi K, Mori T, Tokuyama S. (PubMed)
(2) Toxin-Induced Experimental Models of Learning and Memory Impairment by More SV1, Kumar H2, Cho DY3, Yun YS4, Choi DK. (PubMed)
(3) The relationship between Bcl-gene expression and learning and memory impairment in chronic aluminum-exposed rats by Niu Q1, Yang Y, Zhang Q, Niu P, He S, Di Gioacchino M, Conti P, Boscolo P. (PubMed)
Wednesday, April 24, 2019
Ginger Reverses the Cognitive Impairment Caused by Oxidative Stress
Scientists may have found a pungent spice which processes a potential to inhibit the early onset of cognitive impairment, a major cause of neurodegenerative diseases in the elderly, according to studies.
Cognitive impairment is a medical condition characterized by a noticeable loss of cognitive abilities, involved memory and thinking skill. Cognitive impairment in the elderly is an early sign that can lead to the progression of dementia, including Alzheimer's.
The neuro impairment can be caused by brain damage due to physical impact, a medical condition such as mild stroke. In the elderly, the syndrome was associated with the build-up of plagues or tangles in the neurons that affect the cells in transmitting information to the others.
Some researchers suggested that enlargement of the brain's fluid-filled spaces and shrinkage of the hippocampus may also cause the onset of cognitive impairment.
Dr. Terry L. Davidson PhD and colleagues in examing the risk of cognitive impairment of people who follow the Western diet suggested that the Western diet may play a critic role in facilitating the widespread of cognitive impairment in the elderly in the Western world compared to the people who follow the traditional diet with a high amount of fruits and vegetables.
The doctoral team wrote, "Epidemiological studies indicate that Western diet intake, and the weight gain and obesity that it promotes, are associated not only with late-life dementia but also with poorer cognitive flexibility and inhibitory control across the lifespan".
And, " In addition, rodents maintained on a Western diet are impaired on hippocampal-dependent inhibitory learning and memory tasks and exhibit increased blood-brain barrier permeability, hippocampal inflammation, and decreased hippocampal neurogenesis and plasticity. Interference with neuroendocrine signaling may also contribute to hippocampal dysfunction".
The results strongly suggested the negative impacts of the Western diet in the initiation of a vicious cycle of progressive weight gain and cognitive decline.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of cognitive impairment examined the ginger effect on oxidative stress in the induction of cognitive impairment.
The study included 60 participants randomly assigned to receive a placebo or standardized plant extract at doses of 400 and 800 mg once daily for 2 months.
Ginger-treated groups had significantly decreased P300 latencies, increased N100 and P300 amplitudes, and exhibited enhanced working memory.
After one month of treatment, Zingiber officinale treated group at a dose of 800 mg showed a significant increase in N100 amplitude. After two months, Zingiber officinale treated group at doses of 400 and 800 mg showed a significant increase in P300 amplitude.
Furthermore, Zinigber officinale treated group at a dose of 800 mg showed a significant increase in N100 amplitude and decreased P300 latency.
Therefore, ginger is a potential cognitive enhancer for middle-aged women.
The P300 wave is a measurable direct reaction of the brain to a certain sensory, cognitive or mechanical stimulus against cognitive dysfunction. P300 latency is found to increase in patients with Alzheimer's disease.
The increase of N100 and N300 auditory sensory gating could reflect mechanisms involved in protecting higher-order cognitive functions. P300 measurements are used to measure the increasing sensitivity to early cognitive decline or disease progression in AD patients.
In order to reveal more information about the ginger activity against cognitive impairment, researchers examined the ginger effects on healthy brains in mice.
GE administration significantly improved the ability of mice to recognize novel objects, indicating improvements in learning and memory.
GE administration led to elevated NGF levels in both the mouse hippocampus and rat glioma C6 cells.
Where nerve growth factor (NGF) is involved primarily in the growth, and maintenance, proliferation, and survival of neurons, thus improving the cognitive function.
Moreover, GE administration also resulted in phosphorylation of extracellular-signal-regulated kinase (ERK) and cyclic AMP response element-binding protein (CREB), linking to the regulation of synaptic plasticity and memory formation revealed by Western blotting analysis.
Additionally, GE treatment significantly increased pre- and post-synaptic markers that pass nerve impulse from an axon terminal to a neuron, muscle cell, or gland cell, and synaptophysin, and PSD-95, which are related to synapse formation in the brain.
Dr. Lim S, the lead scientist in the final report wrote, "GE has a synaptogenic effect via NGF-induced ERK/CREB activation, resulting in memory enhancement".
Where The MAPK/ERK pathway is a chain of proteins in the cell that transmits information from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
Taken altogether, ginger processed a high amount antioxidant bioactive compounds may be considered a functional remedy for the prevention and combined with the primary therapy for the treatment of cognitive impairment, pending to the confirmation of large sample and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Zingiber officinale Improves Cognitive Function of the Middle-Aged Healthy Women by Naritsara Saenghong, 1 Jintanaporn Wattanathorn, 2 ,* Supaporn Muchimapura, 2Terdthai Tongun, 2 Nawanant Piyavhatkul, 3 Chuleratana Banchonglikitkul, 4 andTanwarat Kajsongkram. (PubMed)
(2) Ginger improves cognitive function via NGF-induced ERK/CREB activation in the hippocampus of the mouse by Lim S1, Moon M2, Oh H1, Kim HG1, Kim SY3, Oh MS. (PubMed)
(3) Chapter 27 - Western Diet and Cognitive Impairment by Terry L.Davidson Ph.D., Camille H.Sample Ph.D., Scott E.Kanoski Ph.D. (Science Direct)
Cognitive impairment is a medical condition characterized by a noticeable loss of cognitive abilities, involved memory and thinking skill. Cognitive impairment in the elderly is an early sign that can lead to the progression of dementia, including Alzheimer's.
The neuro impairment can be caused by brain damage due to physical impact, a medical condition such as mild stroke. In the elderly, the syndrome was associated with the build-up of plagues or tangles in the neurons that affect the cells in transmitting information to the others.
Some researchers suggested that enlargement of the brain's fluid-filled spaces and shrinkage of the hippocampus may also cause the onset of cognitive impairment.
Dr. Terry L. Davidson PhD and colleagues in examing the risk of cognitive impairment of people who follow the Western diet suggested that the Western diet may play a critic role in facilitating the widespread of cognitive impairment in the elderly in the Western world compared to the people who follow the traditional diet with a high amount of fruits and vegetables.
The doctoral team wrote, "Epidemiological studies indicate that Western diet intake, and the weight gain and obesity that it promotes, are associated not only with late-life dementia but also with poorer cognitive flexibility and inhibitory control across the lifespan".
And, " In addition, rodents maintained on a Western diet are impaired on hippocampal-dependent inhibitory learning and memory tasks and exhibit increased blood-brain barrier permeability, hippocampal inflammation, and decreased hippocampal neurogenesis and plasticity. Interference with neuroendocrine signaling may also contribute to hippocampal dysfunction".
The results strongly suggested the negative impacts of the Western diet in the initiation of a vicious cycle of progressive weight gain and cognitive decline.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of cognitive impairment examined the ginger effect on oxidative stress in the induction of cognitive impairment.
The study included 60 participants randomly assigned to receive a placebo or standardized plant extract at doses of 400 and 800 mg once daily for 2 months.
Ginger-treated groups had significantly decreased P300 latencies, increased N100 and P300 amplitudes, and exhibited enhanced working memory.
After one month of treatment, Zingiber officinale treated group at a dose of 800 mg showed a significant increase in N100 amplitude. After two months, Zingiber officinale treated group at doses of 400 and 800 mg showed a significant increase in P300 amplitude.
Furthermore, Zinigber officinale treated group at a dose of 800 mg showed a significant increase in N100 amplitude and decreased P300 latency.
Therefore, ginger is a potential cognitive enhancer for middle-aged women.
The P300 wave is a measurable direct reaction of the brain to a certain sensory, cognitive or mechanical stimulus against cognitive dysfunction. P300 latency is found to increase in patients with Alzheimer's disease.
The increase of N100 and N300 auditory sensory gating could reflect mechanisms involved in protecting higher-order cognitive functions. P300 measurements are used to measure the increasing sensitivity to early cognitive decline or disease progression in AD patients.
In order to reveal more information about the ginger activity against cognitive impairment, researchers examined the ginger effects on healthy brains in mice.
GE administration significantly improved the ability of mice to recognize novel objects, indicating improvements in learning and memory.
GE administration led to elevated NGF levels in both the mouse hippocampus and rat glioma C6 cells.
Where nerve growth factor (NGF) is involved primarily in the growth, and maintenance, proliferation, and survival of neurons, thus improving the cognitive function.
Moreover, GE administration also resulted in phosphorylation of extracellular-signal-regulated kinase (ERK) and cyclic AMP response element-binding protein (CREB), linking to the regulation of synaptic plasticity and memory formation revealed by Western blotting analysis.
Additionally, GE treatment significantly increased pre- and post-synaptic markers that pass nerve impulse from an axon terminal to a neuron, muscle cell, or gland cell, and synaptophysin, and PSD-95, which are related to synapse formation in the brain.
Dr. Lim S, the lead scientist in the final report wrote, "GE has a synaptogenic effect via NGF-induced ERK/CREB activation, resulting in memory enhancement".
Where The MAPK/ERK pathway is a chain of proteins in the cell that transmits information from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
Taken altogether, ginger processed a high amount antioxidant bioactive compounds may be considered a functional remedy for the prevention and combined with the primary therapy for the treatment of cognitive impairment, pending to the confirmation of large sample and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Zingiber officinale Improves Cognitive Function of the Middle-Aged Healthy Women by Naritsara Saenghong, 1 Jintanaporn Wattanathorn, 2 ,* Supaporn Muchimapura, 2Terdthai Tongun, 2 Nawanant Piyavhatkul, 3 Chuleratana Banchonglikitkul, 4 andTanwarat Kajsongkram. (PubMed)
(2) Ginger improves cognitive function via NGF-induced ERK/CREB activation in the hippocampus of the mouse by Lim S1, Moon M2, Oh H1, Kim HG1, Kim SY3, Oh MS. (PubMed)
(3) Chapter 27 - Western Diet and Cognitive Impairment by Terry L.Davidson Ph.D., Camille H.Sample Ph.D., Scott E.Kanoski Ph.D. (Science Direct)
Phytochemical 3,3'-Diindolylmethane, The Potential Melanoma Inhibitor, According to Studies
3,3'-Diindolylmethane may be the next bioactive compound for the treatment of melanoma with no side effects, according to studies.
Melanoma is skin cancer caused by the alternation of melanocytes DNA in the skin pigment, leading to the formation of moles that change in the color, size or shape on the skin.
Most cases of melanoma start in the melanocytes or pigment-producing cells in the outer layer of the skin. However, at the later stage, the cancer cells can travel through the circulation of blood and fluids to infect other healthy cells and tissue, leading to secondary metastasis.
The liver, lungs, bones, and brain are most often affected by melanoma metastases.
According to statistic, the risk of melanoma is largely depended on the race. the lifetime risk of getting melanoma is about 2.5% (1 in 40) for whites, 0.1% (1 in 1,000) for blacks, and 0.5% (1 in 200) for Hispanics.
The 5 years survival rate of melanoma is closed to 100% if the disease is diagnosed in the localized stages.
In the US, every year, approximately 96,480 new melanomas are diagnosed, leading to the death of 7,000 people.
In North America, most cases of melanoma are associated with UVB exposure, causing the alteration of the cell DNA.
Dr. S A Oliveria, the lead scientist said, "Sun-sensitive phenotypes and reported sunburn were associated with an increased risk of melanoma" and "intense sun exposure is causal for melanoma in those prone to sunburn".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a natural compound for the treatment of melanoma compared the effects of
kaempferol (Kem), genistein (Gen), and 3'3-diindolylmethane (DIM) on melanoma cell viability.
Treatment of A375SM melanoma cells with the tested phytochemicals resulted in inhibition of cell growth.
DIM exerted the strong inhibition against the A375SM melanoma cells by increasing the tumor suppressive gene expression, p21 and decreasing the gene expression associated with the cancer cell proliferation and survival.
Injection of DIM and other tested phytochemical also induced the expression of pro-apoptotic pathways against the tested cancer cell line and deactivated the anti-apoptotic pathways.
Furthermore, DIM and tested phytochemical also enhanced the activity of ROS in the induction of cytotoxicity without causing harm to the healthy cells.
Dr. Heo JR and colleagues said, "These results indicate that phytochemicals (kaempferol (Kem), genistein (Gen), and 3'3-diindolylmethane (DIM)) are potentially useful in treatments for melanoma due to their ability to inhibit melanoma cell growth and division".
Taken altogether, 3,3'-Diindolylmethane may be considered a supplement for the prevention and combined with primary medicine for the treatment of melanoma, pending to the confirmation of large sample size and multicenter human study.
Injection of DIM in a form of supplement should be taken with exceptional care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phytochemical-induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis and differentiation in malignant melanoma cells by Heo JR1, Lee GA1, Kim GS1, Hwang KA1, Choi KC. (PubMed)
(2) Novel 3,3'-diindolylmethane derivatives: synthesis and cytotoxicity, structural characterization in solid state by Maciejewska D1, Rasztawicka M, Wolska I, Anuszewska E, Gruber B. (PubMed)
(3) Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate by Julia A Newton-Bishop, Yu-Mei Chang, Faye Elliott, May Chan, Susan Leake, Birute Karpavicius, Sue Haynes, Elaine Fitzgibbon, Kairen Kukalizch, Juliette Randerson-Moor, David E Elder,* D Timothy Bishop, and Jennifer H Barrett. (PMC)
Melanoma is skin cancer caused by the alternation of melanocytes DNA in the skin pigment, leading to the formation of moles that change in the color, size or shape on the skin.
Most cases of melanoma start in the melanocytes or pigment-producing cells in the outer layer of the skin. However, at the later stage, the cancer cells can travel through the circulation of blood and fluids to infect other healthy cells and tissue, leading to secondary metastasis.
The liver, lungs, bones, and brain are most often affected by melanoma metastases.
According to statistic, the risk of melanoma is largely depended on the race. the lifetime risk of getting melanoma is about 2.5% (1 in 40) for whites, 0.1% (1 in 1,000) for blacks, and 0.5% (1 in 200) for Hispanics.
The 5 years survival rate of melanoma is closed to 100% if the disease is diagnosed in the localized stages.
In the US, every year, approximately 96,480 new melanomas are diagnosed, leading to the death of 7,000 people.
In North America, most cases of melanoma are associated with UVB exposure, causing the alteration of the cell DNA.
Dr. S A Oliveria, the lead scientist said, "Sun-sensitive phenotypes and reported sunburn were associated with an increased risk of melanoma" and "intense sun exposure is causal for melanoma in those prone to sunburn".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a natural compound for the treatment of melanoma compared the effects of
kaempferol (Kem), genistein (Gen), and 3'3-diindolylmethane (DIM) on melanoma cell viability.
Treatment of A375SM melanoma cells with the tested phytochemicals resulted in inhibition of cell growth.
DIM exerted the strong inhibition against the A375SM melanoma cells by increasing the tumor suppressive gene expression, p21 and decreasing the gene expression associated with the cancer cell proliferation and survival.
Injection of DIM and other tested phytochemical also induced the expression of pro-apoptotic pathways against the tested cancer cell line and deactivated the anti-apoptotic pathways.
Furthermore, DIM and tested phytochemical also enhanced the activity of ROS in the induction of cytotoxicity without causing harm to the healthy cells.
Dr. Heo JR and colleagues said, "These results indicate that phytochemicals (kaempferol (Kem), genistein (Gen), and 3'3-diindolylmethane (DIM)) are potentially useful in treatments for melanoma due to their ability to inhibit melanoma cell growth and division".
Taken altogether, 3,3'-Diindolylmethane may be considered a supplement for the prevention and combined with primary medicine for the treatment of melanoma, pending to the confirmation of large sample size and multicenter human study.
Injection of DIM in a form of supplement should be taken with exceptional care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phytochemical-induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis and differentiation in malignant melanoma cells by Heo JR1, Lee GA1, Kim GS1, Hwang KA1, Choi KC. (PubMed)
(2) Novel 3,3'-diindolylmethane derivatives: synthesis and cytotoxicity, structural characterization in solid state by Maciejewska D1, Rasztawicka M, Wolska I, Anuszewska E, Gruber B. (PubMed)
(3) Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate by Julia A Newton-Bishop, Yu-Mei Chang, Faye Elliott, May Chan, Susan Leake, Birute Karpavicius, Sue Haynes, Elaine Fitzgibbon, Kairen Kukalizch, Juliette Randerson-Moor, David E Elder,* D Timothy Bishop, and Jennifer H Barrett. (PMC)
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