Soy and Anti-Photoaging

Posted by Chantel M. ©2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution license
(http://creativecommons.org/licenses/by/3.0/).

In a study of "Anti-Photoaging Effects of Soy Isoflavone Extract (Aglycone and Acetylglucoside Form) from Soybean Cake" by Chieh-Chen Huang, Bo-Yang Hsu, Nan-Lin Wu, Wen-Huei Tsui, Tzu-Ju Lin, Ching-Chieh Su and Chi-Feng Hung. researchers found that
1. Soy Isoflavone Extract Fraction 3 Inhibits UVB-Induced Keratinocyte Death,
2. Soy Isoflavone Extract Fraction 3 Attenuates the Level of Erythema and TEWL after UVB.
3. Soy Isoflavone Extract Fraction 3 Reduces the Epidermal Thickness
Exposure
4. Soy Isoflavone Extract Fraction 3 Decreases the Depletion of Catalase after UVB Exposure
5. Soy Isoflavone Extract Fraction 3 Suppresses the Expression of COX-2 and PCNA after UVB
Exposure
and concluded that In summary, our results demonstrated that soy isoflavone extract Fraction 3 from soybean cake
could prevent human keratinocyte apoptosis, attenuate the level of erythema and TEWL, reduce the
epidermal thickness and increase the catalase activity and inhibit COX-2 and PCNA expression in
response to UVB exposure. The results imply that Fraction 3 could decrease the UVB-induced
oxidative stress, inflammation and skin cell damage. In addition, in comparison with soy isoflavone
extract ISO-1 and genistein, Fraction 3 possessed the highest efficiency in reducing UVB-induced
oxidative stress and preventing human keratinocyte death. Therefore, the soy isoflavone extract
Fraction 3 is a superior anti-photoaging agent for skin care, and the advantages include the properties
that it is non-toxic, easily accessible, economical, convenient and environmentally friendly.