In a study of " Does genotype and equol-production status affect response to isoflavones? Data from a pan-European study on the effects of isoflavones on cardiovascular risk markers in post-menopausal women" by Vafeiadou K, Hall WL, Williams CM. (Source: Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, Whiteknights, University of Reading, UK. firstname.lastname@example.org, Proc Nutr Soc. 2006 Feb;65(1):106-15), posted in
US National Library of Medicine National Institutes of Health, researchers found that there are no differences in response to isoflavones according to equol-production status. However, differences in HDL-cholesterol and vascular cell adhesion molecule 1 response to isoflavones v. placebo are evident with specific ERbeta genotypes. In conclusion, isoflavones have beneficial effects on C-reactive protein, but not other cardiovascular risk markers. However, specific ERbeta gene polymorphic subgroups may benefit from isoflavone supplementation.