Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
According to the study of "Dietary phytoestrogens maintain contractile responses to carbachol with age in the female rat isolated bladder" by Owen SJ, Rose'Meyer RB, Massa HM., posted in US National Library of Medicine National Institutes of Health, researchers found that The contractile response to carbachol, in 12 week old female rats did not change as a result of dietary phytoestrogens or ovariectomy (P>0.05). At 24 weeks of age, detrusor muscle strip responses to carbachol from non-soy fed ovariectomised rats were attenuated (P<0.05). At 52 weeks, bladder detrusor strip responses to carbachol were reduced in all treatment groups with the exception of the soy-fed sham operated rats and concluded that These results suggest an age-related reduction in the contractile response of the detrusor to the muscarinic receptor agonist carbachol, which may be prevented by long term dietary phytoestrogen intake.
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