Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
According to the study of "High dose of phytoestrogens can reverse the antiestrogenic effects of clomiphene citrate on the endometrium in patients undergoing intrauterine insemination: a randomized trial" by Unfer V, Casini ML, Costabile L, Mignosa M, Gerli S, Di Renzo GC. posted in US National Library of Medicine National Institutes of Health, researchers found that Both treatments increased follicle-stimulating hormone, luteinizing hormone, and 17beta-estradiol plasma concentrations, but the differences were not statistically significant. However, the differences in endometrial thickness of the two groups were statistically significant. No significant differences in the pulsatility index values and in the number of preovulatory follicles were noted, and concluded that a high dose of phytoestrogens can reverse the deleterious effects of clomiphene citrate on endometrial thickness and could contribute to higher pregnancy rates.