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Tuesday, September 6, 2011

Soy and Lipotoxicity in Liver

Posted by Chantel M. Contributed by The Journal of Nutrition

In a study of "Soy Protein Affects Serum Insulin and Hepatic SREBP-1 mRNA and Reduces Fatty Liver in Rats" by Claudia Ascencio, Nimbe Torres, Fernando Isoard-Acosta, Francisco J. Gómez-Pérez, Rogelio Hernández-Pando and Armando R. Tovar (Departamentos de Fisiología de la Nutrición,; Endocrinología y Metabolismo, y; Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán," Mexico City, Mexico) posted in The Journal of Nutrition, researchers found that rats fed the soy protein diet had significantly lower expression of SREBP-1 mRNA than rats fed the casein diet. Soy protein intake also reduced the expression of fatty acid synthase (FAS) and malic enzyme, leading to low hepatic lipid depots of triglycerides and cholesterol, whereas rats fed the casein diet developed fatty liver. These data suggest that soy protein regulates SREBP-1 expression by modulating serum insulin concentration, thus preventing the development of fatty liver.

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