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Friday, September 2, 2011

Soy and Renal Cell Carcinoma

Potsed ed by Chantel M. contributed by The Official Journal of Societe Internationale D' Urology

In a study of "Antiproliferative and antiangiogenic activities of genistein in human renal cell carcinoma" by Hiroto Sasamura, Atsushi Takahashi, Jinyang Yuan, Hiroshi Kitamura, Naoya Masumori, Noriomi Miyao, Naoki Itoh,Taiji Tsukamoto posted in The Official Journal of Societe Internationale D' Urology, researchers found that Treatment with genistein for 48 hours inhibited cell proliferation in a dose-dependent manner and 100 μg/mL genistein inhibited it in a time-dependent manner. A dose of 50 μg/mL genistein clearly induced cell apoptosis. The vascular volume after implantation of the Millipore filter chamber containing RCC cells increased to threefold that without RCC cells. Genistein in the Millipore filter chamber significantly decreased the neovascularization induced by human RCC cells in vivo. and concluded that the results of this study demonstrated that genistein inhibited cell proliferation, induced apoptosis, and suppressed in vivo angiogenesis in human RCC cells. Genistein may be a promising antitumorigenic and antiangiogenic agent for the treatment and prevention of RCC.

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