Posted by Chantel M. Contributed by American Association for cancer research.
According to a study of " Soy Phytochemicals Prevent Orthotopic Growth and Metastasis of Bladder Cancer in Mice by Alterations of Cancer Cell Proliferation and Apoptosis and Tumor Angiogenesis." by Ajita V. Singh, Adrian A. Franke, George L. Blackburn, and Jin-Rong Zhou, researchers indicated in the section of "Effects of soy phytochemicals on orthotopic growth and metastasis of bladder tumors", the intrabladder 253J B-V human bladder tumor model was used as a clinically relevant in vivo model to evaluate the effects of SPC and genistin on tumor growth and metastasis. We used genistin because it is the natural form of genistein in soy. We used SPC because it represents soy phytochemicals that are consumed by humans. Dietary soy treatments did not significantly reduce body weight or food intake (data not shown). The effects of dietary treatments on tumor growth and metastasis are shown in Fig. 5 . Tumors from those treated with SPC and genistin were reduced by 52% (P < 0.05) and 54% (P < 0.05), respectively, compared with the control group ( Fig. 5A).....
In the section of "Effects of soy phytochemicals on tumor apoptosis, angiogenesis, and proliferation." researchers also indicated that tumor cell apoptotic index and tumor angiogenesis were measured by TUNEL assay and factor VIII staining, respectively. Apoptotic indices of primary tumors in mice treated with SPC and genistin were significantly increased by 263% (P < 0.01) and 265% (P < 0.01), respectively, whereas microvessel densities of primary tumors in mice treated with SPC and genistin were significantly reduced by 35% (P < 0.05) and 50% (P < 0.05), respectively, compared with the control.
In conclusion, researchers wrote that we found that genistin and SPC significantly inhibited the growth of a poorly differentiated human bladder tumor associated with induction of tumor cell apoptosis and inhibition of tumor angiogenesis. In particular, SPC, but not genistin, significantly inhibited lung metastases and reduced NF-κB expression and circulating level of IGF-I. The results from this study, together with our previous studies, suggest that SPC may contain potent antimetastasis component(s). The results from our studies suggest further clinical studies should be warranted to apply soy phytochemicals, such as SPC, as a potent prevention regimen for bladder cancer progression. This orthotopic human bladder tumor model also provides a clinically relevant experimental tool for assessing potential preventive activity of other dietary components against bladder tumor growth and metastasis.
Now, we have contradiction evidences that soy can cause and treat bladder cancer in studies. Further of clarification should be necessary.
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