Post by Chantel M. Contributed by 2010 American Society for Nutrition, previous posted in The American Journals in Clinical Nutrition
In a study of Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan" by Taichi Shimazu, Manami Inoue, Shizuka Sasazuki, Motoki Iwasaki, Norie Sawada, Taiki Yamaji, and Shoichiro Tsugane, for the Japan Public Health Center–based Prospective Study Group. The result during 11 y (671,864 person-years) of follow-up, we documented 481 male and 178 female lung cancer cases. In men we found an inverse association between isoflavone intake and risk of lung cancer in never smokers (n = 13,051; multivariate HR in the highest compared with the lowest quartile of isoflavone intake: 0.43; 95% CI: 0.21, 0.90; P for trend = 0.024) but not in current or past smokers. A similar, nonsignificant inverse association was seen in never-smoking women (n = 38,211; HR: 0.67; 95% CI: 0.41, 1.10; P for trend = 0.135). We also tested effect modification by smoking status (P for interaction = 0.085 in men and 0.055 in men and women combined), researchers concluded that In a large-scale, population-based, prospective study in Japan, isoflavone intake was associated with a decreased risk of lung cancer in never smokers.
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