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Monday, December 12, 2011

Soy and carnitine palmitoyl transferase 1A (CPT1A) activities

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the study of "Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L-carnitine" by Shin ES, Cho SY, Lee EH, Lee SJ, Chang IS, Lee TR, posted in US National Library of Medicine National Institutes of Health, found that Genistein and daidzein can up-regulate CPT1A enzyme activity through up-regulation of CPT1A transcription. Co-treatment of L-carnitine and genistein additively increases CPT1A enzyme activity in HepG2 cells. A stable Huh7 cell line transfected with the CPT1A promoter luciferase reporter gene was established and characterized.

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