Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
In the study of "Genistein reduces glycosaminoglycan levels in a mouse model of mucopolysaccharidosis type II" by Friso A, Tomanin R, Salvalaio M, Scarpa M, posted in US National Library of Medicine National Institutes of Health, found that Urinary GAG levels were reduced after 10 weeks' treatment with genistein at either 5 or 25 mg.kg(-1).day(-1). In tissue samples from liver, spleen, kidney and heart, a reduction in GAG content was observed with both dosages, after 10 weeks' treatment. Decreased GAG deposits in brain were observed after genistein treatment in some animals.
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