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Tuesday, September 9, 2014

Herbal Thujae occidentalis and Hair Loss (Androgenetic alopecia)

Posted by Chantel Martiromo

Decreased hormonal secretions due to aging stimulates the production of the enzyme 5-alpha reductase to converse testosterone to gihydro-testosterones DHT, affecting hair to grow back thinner or not grown back at all.  DHT shrinks the follicles, causing hair thins and hair receded at the forehead, crown and temple for men and thins over the entire scalp for women. Herbal treatment for hair loss has existed throughout human history, but epidemiological studies, linking herbs effectiveness in treating hair loss have produced inconsistent results.
Androgenetic alopecia 
Androgenetic alopecia is a common hair loss in men and women. In men, it causes baldness patterns, receding at the forehead. In women, the hair becomes thinner all over the head, and the hairline does not recede.

Thujae occidentalis is an evergreen coniferous tree, belonging to the cypress family, native to the United States and the southeast of Canada. the herb has been used in folk medicine in treating warts, ringworm and thrush.
In HEK 293 cell line derived from human embryonic kidney cells grown in tissue culture, with expressing human 5alpha-reductase (type 2), Thujae occidentalis semen (TOS) extract in comparison with gamma-linolenic acid and finasteride (a synthetic drug used to be for the treatment of benign prostatic hyperplasia), topically applied to fuzzy rat and androchronogenetic alopecia (AGA) mouse, showed  effectiveness in treating male pattern baldness by dictating androgen conversion with higher inhibition activity of 5alpha-reductase type 2 than that of gamma-linolenic acid, but lower than that of finasteride. These result indicated that the extract may be a potent agent for treating male baldness(1).

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References
(1) The extract of Thujae occidentalis semen inhibited 5alpha-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse by Park WS, Lee CH, Lee BG, Chang IS.(PubMed)

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