Posted by Chantel Martiromo
Decreased hormonal secretions due to aging stimulates the production of
the enzyme 5-alpha
reductase to converse testosterone to
gihydro-testosterones DHT, affecting hair to grow back thinner or not
grown back at all. DHT shrinks the follicles, causing hair thins and
hair receded at
the forehead, crown and temple for men and thins over the entire scalp
for women. Herbal treatment for hair loss has existed throughout human
history, but epidemiological studies, linking herbs effectiveness in
treating hair loss have produced inconsistent results.
Androgenetic alopecia is a common hair loss in men and women. In men, it
causes baldness patterns, receding at the forehead. In women, the hair
becomes thinner all over the head, and the hairline does not recede.
Thujae occidentalis is an evergreen coniferous tree, belonging to the
cypress family, native to the United States and the southeast of Canada.
the herb has been used in folk medicine in treating warts, ringworm and
In HEK 293 cell line derived from human embryonic kidney cells grown in
tissue culture, with expressing human 5alpha-reductase (type 2), Thujae
occidentalis semen (TOS) extract in comparison with gamma-linolenic acid
and finasteride (a synthetic drug used to be for the treatment of benign prostatic hyperplasia), topically applied to fuzzy rat and androchronogenetic alopecia
(AGA) mouse, showed effectiveness in treating male pattern baldness
by dictating androgen conversion with higher inhibition activity of
5alpha-reductase type 2 than that of gamma-linolenic acid, but lower
than that of
finasteride. These result indicated that the extract may be a potent
agent for treating male baldness(1).
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(1) The extract of Thujae occidentalis semen inhibited 5alpha-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse by Park WS, Lee CH, Lee BG, Chang IS.(PubMed)
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