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Thursday, September 11, 2014

Herbal Citrullus colocynthis Schrad and Hair Loss (Androgenetic alopecia)

Posted by Chantel Martiromo

Decreased hormonal secretions due to aging stimulates the production of the enzyme 5-alpha reductase to converse testosterone to gihydro-testosterones DHT, affecting hair to grow back thinner or not grown back at all.  DHT shrinks the follicles, causing hair thins and hair receded at the forehead, crown and temple for men and thins over the entire scalp for women. Herbal treatment for hair loss has existed throughout human history, but epidemiological studies, linking herbs effectiveness in treating hair loss have produced inconsistent results.

Androgenetic alopecia is a common hair loss in men and women. In men, it causes baldness patterns, receding at the forehead. In women, the hair becomes thinner all over the head, and the hairline does not recede.
Citrullus colocynthis is a desert viny plant native to the Mediterranean Basin and Asia. The herb has been used in folk medicine for treatments of cancer, carcinoma, endothelioma, leukemia, corns, tumors, etc. In androgen-induced alopecia mice, the petroleum ether extract of C. colocynthis showed an effectiveness in enhancing follicular density, exhibited hair growth-promoting activity in anagenic phase than the standard finasteride(3).
 
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References
(3) Effect of Citrullus colocynthis Schrad fruits on testosterone-induced alopecia by Dhanotia R, Chauhan NS, Saraf DK, Dixit VK.(PubMed)

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