Overcome Male Infertility: The Hemizona Assay

Posted by Chantel Martiromo

Fertility is a natural process to insure the survival of human species. Through natural selection, we produce many offspring when the reproductive system works at it's peak in the suitable environment with plenty of food around. On the other hand, the reproductive system may completely shut down or work at it's minimum state and we produce less offspring, when the environment is hostile including less foods around, war, epidemic, but regardless of all these factors, most women are capable of conceiving during their menstrual cycle before menopause.

Hemizona assay is an analysis to compare the binding capacity of sample sperm of the unfertilized male to the sperm of the fertilized male through manual hand cutting versus micro manipulation in IVF and IUI fertilization.

I. Diagnosis
After splitting the mature and normal egg in half. 1/2 is tested by sample sperm of the infertile male and the other half is tested by the fertilized male sperm through manual hand cutting or micro manipulation. Then the number of sperm bounds to each half and is calculated, and the infertile male's sperm is divided by that from the fertile male's sperm. A figure of less than 0.60 indicates abnormal infertile male's sperm.

Although the success rate of this test is not 100%, the HZA has been found to be predictive of IVF and IUI outcome with positive and negative values of 83% and 95% respectively, according to one study. Therefore, if an infertile couple decides to go through IUI or IVF for conception then the hemizoma test is necessary.

II. Risk
There is no guarantee that a couple who scores high in the hemizoma test will be successful to conceive via IVF or IUI, because there are other factors that may interfere with the process after the fertilized egg or embryo was implanted into the uterus.

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