Posted by Chantel Martiromo
Fertility is a natural process to insure the survival of human
species. Through natural selection, we produce many offspring when the
reproductive system works at it's peak in the suitable environment with
plenty of food around. On the other hand, the reproductive system may
completely shut down or work at it's minimum state and we produce less
offspring, when the environment is hostile including less foods around,
war, epidemic, but regardless of all these factors, most women are
capable of conceiving during their menstrual cycle before menopause.
The test is to detect the inherited fertility disorder of the infertile male to avoid any unnecessary
fertility treatments for women.
semen sperm is taken from the infertile male in the clinic laboratory
and the surface of sperm is screened for ubiquintin which is a small,
highly-conserved regulatory protein that is ubiquitously expressed in
complex structures enclosed within membranes.
ubiquitnin is considered a universal marker of semen abnormalities,
including sperm head and tail defects and semen contaminants such as
spermatids, leukocytes and cellular debris.
The semen example is
screened through immunofluorescence and flow cytometry, if there is an
displays of increasing binding of anti-ubiquitin antibodies to sperm
surface, the sample sperm is considered abnormality which increases the
risk of infertility becasues elevated sperm ubiquitin levels have been
associated with reduced fertility or infertility.
This test is
still in developed state, if proven success, it not only helps to avoid
many unnecessary treatments for unfertile couple but also helps to
remove damaged sperm from semen sample before IVF and ICSC.
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