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Sunday, June 23, 2019

Bromelain, the Natural Prevention and Treatment of Inflammatory Bowel Disease (IBD)

An inflammatory bowel (IBD) disease is a group of chronic inflammatory diseases associated with the digestive tract, including ulcerative colitis and Crohn's disease.

Ulcerative colitis has been found to induce chronic inflammation and ulcers in the inner lining of the large intestine (colon) and rectum.

Crohn's disease is a type of IBD associated with the inflammation of the lining of the digestive tract.

According to the statistics, provided by the CDC in the US, IBD affects over 1.3% or 3 million US adults including Crohn's disease or ulcerative colitis in 2015.

Most cases of IBD has been found in older adults in the age of 45 years or older.

Most common symptoms of IBD include diarrhea, fever, and fatigue, abdominal pain and cramping, loss of appetite and unintended weight loss.


In serious cases, some patients may also experience blood in the stool.

If you are experiencing the aforementioned symptoms, please check with your doctor to rule out the possibility.

Conventionally, most cases of IBD are treated with anti-inflammatory medicine, immune suppressor or antibiotics, and drugs that reduce symptoms, depending on the severity of the conditions.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a natural compound for the treatment of colitis, researchers examined the bromelain, a mixture of proteinases derived from pineapple stem in an animal model with inflammatory bowel disease (IBD).

The experiment included IL-10-/- mice treated orally with bromelain in vivo for 5 weeks.

During the study, daily treatment with oral bromelain beginning at age 5 weeks exerted a significant effect in decreased the incidence and severity of spontaneous colitis.

In IL-10-/- mice established colitis by administered to piroxicam, the proteolytic enzyme also significantly decreased the clinical and histologic severity of colonic inflammation.


In the examination of the bromelain adverse effect, researchers found that dermatitis, hair loss, and weight loss due to mucositis were rare in a dose-related manner.

In the wild-type mice, there was no adverse effect found in the dose of 1000 mg bromelain/kg/day for 18 weeks orally.


The findings clearly suggested the efficacy of bromelain for the treatment of inflammatory bowel disease (IBD).

Dr. Hale LP, the lead scientist after taking into account co confounders said, " Although the exact mechanisms by which exogenous proteinases affect bowel inflammation have not yet been determined, the results justify additional studies of this complementary biologically based approach to the treatment of IBD".

Taken altogether, bromelain may be considered supplements for the prevention and treatment of bowel disease (IBD), pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease by Hale LP1, Greer PK, Trinh CT, Gottfried MR. (PubMed)

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