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Monday, June 10, 2019

Turmeric, The Kitchen Spice Which Cures Rheumatoid Arthritis in Vivo with No Side Effects

Rheumatoid Arthritis (RA) is a type of arthritis associated with inflammation that affects mostly the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many older adults.

According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.

Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation.

A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.

The symptoms of RA that affect
* The feet and joints
Patient with rheumatoid arthritis (RA) often associates to valgus deformities of the feet and deformities of gait due to body function in an effort to support the collapsing longitudinal arch of the foot.

* The gait
Dr. Weiss RJ. and the research team at the Karolinska Institutet showed that the kinematic and kinetic gait changes in rheumatoid arthritis (RA) patients are the result of a significant reduction in joint motions, joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range,

* The hands
The deformation of RA's hands can be described through the defects of bone ankylosis as a result of bone damage to the prolonged onset of the disease.

* The Muscle strength
The reduced muscle strength in patients with RA may contribute to the prevalence of functional limitations physically,

Other symptoms of RA include

* Rheumatoid Nodules
Rheumatoid nodules, lump on the skin, closed to the joint have been found to affect the joints of patients with rheumatoid nodules.

* Conjunctival nodules
Although is rare in patients with rheumatoid arthritis, the appearance of the nodules may exhibit the
severity of the underlying disease.

* Morning stiffness
Morning stiffness, as a marker of inflammatory activity in reflecting functional disability and pain is a very common symptom of patients in early rheumatoid arthritis.

If you have some of the aforementioned symptoms, you may have RA. Please make sure you check with your doctor to rule out the possibility.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential treatment of rheumatoid arthritis (RA), researchers investigated the protective activity of two different doses of a mixture of ginger and turmeric rhizomes powder suspended in distilled water (GTaq) against inflammation in an animal model.

Rats adjuvant-induced arthritis (AIA) by a single intradermal injection of 0.1 mL of Complete Freund's adjuvant (containing heat-killed Mycobacterium tuberculosis) into the palmar surface of the left hind paw were given orally and daily (for 28 consecutive days) distilled water as vehicle, indomethacin (1.0 mg/kg body weight), or GTaq (200 or 400 mg/kg body weight) from the day of arthritis induction.

Suspended in distilled water (GTaq)are more effective (4.2-38.4% higher, P < 0.05-0.001) than indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes in ankle joints.

Blood leukocytosis and thrombocytosis associated with the inflammation also reduced by suspended in distilled water (GTaq).

Risk factors involved the risk of cardiovascular disease and kidney damage rats adjuvant-induced arthritis were also decreased by the injection of GTaq.


Further differentiation of the anti-RA activity of GTaq, researchers found that the efficacy of the mixture was attributed to the increasing the food intake and decreasing the systemic inflammation associated with the inhibition of polyarthritis, oxidative stress, and dyslipidemia.
Based on the findings, researchers said, "Ginger-turmeric rhizomes mixture may be effective against RA severity and complications as shown in an AIA rat model".


In order to obtain more information about turmeric anti RA activity, researchers investigated the curcuminoid-containing turmeric extracts in the prevention or treatment of arthritis using streptococcal cell wall (SCW)-induced arthritis.

According to the tested assays, essential oil-depleted turmeric fraction containing 41% of the three major curcuminoids was efficacious in preventing joint inflammation at the start of the disease but not after, the onset of joint inflammation.


Interestingly, compared to other curcumin treatment groups, a commercial sample containing 94% of the three major curcuminoids was more potent in preventing arthritis in the same dose per weight.

These results strongly suggested only the three major curcuminoids found in turmeric process antiarthritic effect, compared to the treatment of the whole food.


In other words, all compounds except three major curcuminoids of the crude turmeric extract may inhibit this protective effect.

Taken altogether, turmeric used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of RA, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
rheumatoid arthritis
(1) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(2) Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis by Funk JL1, Oyarzo JN, Frye JB, Chen G, Lantz RC, Jolad SD, Sólyom AM, Timmermann BN. (PubMed)

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