Ampelopsis japonica (Bai Lian) and Skin Lightening (Whitening)

 Posted by Chantel Martiromo  

Human skin pigmentation is the result of natural selection evolved to prevent damage to skin through regulation of ultraviolet radiated penetration depending to the production of melanin in the skin cells.
Hypo-pigment
a. Vitiligo is defined as a condition of destruction of cells that give your skin its color, causing white patches on your skin.
b. Albinism is a congenital disorder causes of complete or partial absence of pigment in the skin, hair and eyes as a result of restriction of the skin cells from producing melanin
2.Hyper pigment is a result of over production of pigments of certain cells in the skin, causing skin darkening in some area, such as tan or brown patches, commonly on the facial skin
3. Skin discoloring is a result of discoloring your skin in specific spots or very widespread
4. Chloasma is the appearance of brown patches of pigmentation on the forehead, cheeks, and neck
due to hormonal change during pregnancy.
5. Melasma happens to women who have fluctuation of hormones, are taking birth control pills and certain medications. with brownish-grayish patches on the skin, most often on the cheek.
Epidemiological studies, linking herbal medicine in skin lighting may have produced certain interest results(a)(b)(c).
Ampelopsis japonica (Bai Lian)
Bai Lian is also known as Japanese Ampelopsis Root, the bitter, sweet, acrid and cool herb has been used in TCM to redice infection and to treat carbuncles, sores, scalding injuries, dysentery with blood, intestine pain, hemorrhoids as it clears Heat, expels toxins, resolves ulcers, promotes muscle regeneration, etc, by promoting the function of liver channel.

Ampelopsis japonica  may process the property in treating skin hyperpigmentation disorders, such as melisma. According to the study at the Macao Polytechnic Institute,  Linderagalactone c and (+)-n-methyllaurotetanine found in  Ampelopsis japonica  exhibited the strongest prospects in topical formulations, through high predicted tyrosinase binding scores and displayed good skin permeation properties in Surflex-Dock and the QSAR-based Dermal Permeability Coefficient Program (DERMWIN) and Skin Irritation Corrosion Rules Estimation Tool (SICRET) implemented in Toxtree.(1). The screening of 50 extracts from traditional Chinese medicines (TCM) used for tyrosinase activity-inhibiting agents, Ampelopsis japonica showed similar or greater ratio of cell growth IC(50) to cellular tyrosinase IC(50) when compared with other herbs(2).

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References
(a) Tyrosinase modulation by five Rwandese herbal medicines traditionally used for skin treatment by Kamagaju L¹, Morandini R, Bizuru E, Nyetera P, Nduwayezu JB, Stévigny C, Ghanem G, Duez P.(PubMed)
(b) An ethnobotanical survey of medicinal plants used in Rwanda for voluntary depigmentation by Kamagaju L¹, Bizuru E, Minani V, Morandini R, Stévigny C, Ghanem G, Duez P.(PubMed)
(c) Tyrosinase inhibition by extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening by Momtaz S¹, Mapunya BM, Houghton PJ, Edgerly C, Hussein A, Naidoo S, Lall N.(PubMed))
(1) In silico prediction of the cosmetic whitening effects of naturally occurring lead compounds by Fong P¹, Tong HH.(PubMed)
(2) Screening of Chinese herbal medicines for antityrosinase activity in a cell free system and B16 cells by Ye Y¹, Chou GX, Mu DD, Wang H, Chu JH, Leung AK, Fong WF, Yu ZL(PubMed)