Posted by Chantel Martiromo
Human skin pigmentation is the result of natural selection evolved to
prevent damage to skin through regulation of ultraviolet radiated
penetration depending to the production of melanin in the skin cells.
a. Vitiligo is defined as a condition of destruction of cells that give your skin its color, causing white patches on your skin.
b. Albinism is a congenital disorder causes of complete or
partial absence of pigment in the skin, hair and eyes as a result
of restriction of the skin cells from producing melanin
2.Hyper pigment is a result of over production of pigments of
certain cells in the skin, causing skin darkening in some area, such as
tan or brown patches, commonly on the facial skin
3. Skin discoloring is a result of discoloring your skin in specific spots or very widespread
4. Chloasma is the appearance of brown patches of pigmentation on the forehead, cheeks, and neck
due to hormonal change during pregnancy.
5. Melasma happens to women who have fluctuation of hormones, are
taking birth control pills and certain medications. with
brownish-grayish patches on the skin, most often on the cheek.
Epidemiological studies, linking herbal medicine in skin lighting may have produced certain interest results(a)(b)(c).
Nardostachys chinensis(Gan Song)
Gan Song also known as Nardostachyos Root and Rhizome. The herb has been
used in traditional Chinese medicine to treat melasma and lentigines,
move Qi, calm pain, eliminate stagnation and invigorate the Spleen.
According to Pusan National University, the active 20% methanol
chromatographic fraction from the ethyl acetate layer (PPNC) showed to
suppress the melanin synthesis s, through stimulated MEK/ERK
phosphorylation and PI3K/Akt signaling with suppressing cAMP levels and
subsequently stimulating MITF and TRPs down-regulation(10).
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(a) Tyrosinase modulation by five Rwandese herbal medicines traditionally used for skin treatment by Kamagaju L1, Morandini R, Bizuru E, Nyetera P, Nduwayezu JB, Stévigny C, Ghanem G, Duez P.(PubMed)
(b) An ethnobotanical survey of medicinal plants used in Rwanda for voluntary depigmentation by Kamagaju L1, Bizuru E, Minani V, Morandini R, Stévigny C, Ghanem G, Duez P.(PubMed)
(c) Tyrosinase inhibition by extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening by Momtaz S1, Mapunya BM, Houghton PJ, Edgerly C, Hussein A, Naidoo S, Lall N.(PubMed))
(10) Partially purified components of Nardostachys chinensis suppress
melanin synthesis through ERK and Akt signaling pathway with cAMP
down-regulation in B16F10 cells by Jang JY1, Kim HN, Kim YR, Choi WY, Choi YH, Shin HK, Choi BT.(PubMed)