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Monday, May 5, 2014

Healthy Food Grape and Skin Aging

Posted by Chantel Martiromo 

Skin aging is one of most visible ageing process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin,  affect skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading  injuries damage regulation pathways of skin,  including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
The degradation of the epidermal and dermal layers of the extracellular matrix (ECM), the non-cellular component present within all tissues and organs, such as UV Exposure, decline of lysosomal/endosomal cathepsin K, S and V activity(c) as well as environment factors such as irregular dryness, dark/light pigmentation, sallowness, severe atrophy, telangiectases, premalignant lesions, laxity, leathery appearance and deep wrinkling, etc.,  cause modification of the surface of skin and the physical properties of that lead to skin aging. Certain foods have been found to be effective in protect the skin against natural aging, including green tea and garlic.
Grape is a woody vines of the genus Vitis, belong to the family Vitaceae, native to southern Turkey.
Trans-resveratrol, a polyphenol extracted from grape, showed a remarkable improvement in decreased aging signs(18). In facial skin morphology and functionality, combination of grape seed extract and soy phospholipids showed to have the potential in induced signal transduction pathways in facial hypodermis, resulting in anti-aging effects throughout all skin compartments, including dermal and epidermal layers(19). Clinically and biometrically, composition of lycopene, acerola extract, grape seed extract and Biomarine ComplexT showed to  increase parameters of cutaneous hydration, reduction of pH, ultrasound density and a histological increment of collagen and elastic fibers (both on the face and arm), through a reduction of seborrhea (only on the face)(20).
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References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(c) Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis by Sage J1, De Quéral D2, Leblanc-Noblesse E2, Kurfurst R2, Schnebert S2, Perrier E2, Nizard C2, Lalmanach G3, Lecaille F4.(PubMed)
 
(18) Enhanced antioxidant effect of trans-resveratrol: potential of binary systems with polyethylene glycol and cyclodextrin by Moyano-Mendez JR1, Fabbrocini G, De Stefano D, Mazzella C, Mayol L, Scognamiglio I, Carnuccio R, Ayala F, La Rotonda MI, De Rosa G(PubMed)
(19) Hypodermal delivery of cosmetic actives for improved facial skin morphology and functionality by Bojanowski K.(PubMed)
(20) Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and Biomarine Complex in photoaged human skin by Costa A1, Lindmark L, Arruda LH, Assumpção EC, Ota FS, Pereira Mde O, Langen SS(PubMed)

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