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Monday, May 19, 2014

Spicebush Root (Wu Yao) and Skin Lightening (Whitening)

 Posted by Chantel Martiromo  

Human skin pigmentation is the result of natural selection evolved to prevent damage to skin through regulation of ultraviolet radiated penetration depending to the production of melanin in the skin cells.
1. Hypo-pigment
a. Vitiligo is defined as a condition of destruction of cells that give your skin its color, causing white patches on your skin.
b. Albinism is a congenital disorder causes of complete or partial absence of pigment in the skin, hair and eyes as a result of restriction of the skin cells from producing melanin
2.Hyper pigment is a result of over production of pigments of certain cells in the skin, causing skin darkening in some area, such as tan or brown patches, commonly on the facial skin
3. Skin discoloring is a result of discoloring your skin in specific spots or very widespread
4. Chloasma is the appearance of brown patches of pigmentation on the forehead, cheeks, and neck
due to hormonal change during pregnancy.
5. Melasma happens to women who have fluctuation of hormones, are taking birth control pills and certain medications. with brownish-grayish patches on the skin, most often on the cheek.
Epidemiological studies, linking herbal medicine in skin lighting may have produced certain interest results(a)(b)(c).
Wu Yao is also known as Spicebush Root. The acrid and warm herb has been used in TCM  as   increased metabolism, antibiotic, anti-viral agent andto harmonize peristalsis of digestive tract, release intestinal gas, etc., as it moves Qi, warms the Kidneys. calms pain, etc. by enhancing the functions of lung, spleen, kidney and bladder.channels.
The study at Macao Polytechnic Institute, in the finding of herbal medicine used as tyrosinase inhibitors and for treatment of skin hyperpigmentation disorders, showed a promising result of
Spicebush Root's chemical constituents in tyrosinase binding scores and displayed good skin permeation properties and minimal potential for skin sensitization and irritation(5). Other study at the Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, found that Spicebush Root consists appreciable antityrosinase activity with more than 50% inhibition against mushroom tyrosinase activity(6).
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(a) Tyrosinase modulation by five Rwandese herbal medicines traditionally used for skin treatment by Kamagaju L1, Morandini R, Bizuru E, Nyetera P, Nduwayezu JB, Stévigny C, Ghanem G, Duez P.(PubMed)
(b) An ethnobotanical survey of medicinal plants used in Rwanda for voluntary depigmentation by Kamagaju L1, Bizuru E, Minani V, Morandini R, Stévigny C, Ghanem G, Duez P.(PubMed)
(c) Tyrosinase inhibition by extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening by Momtaz S1, Mapunya BM, Houghton PJ, Edgerly C, Hussein A, Naidoo S, Lall N.(PubMed))
(5) In silico prediction of the cosmetic whitening effects of naturally occurring lead compounds by Fong P1, Tong HH.(PubMed)
(6) Screening of Chinese herbal medicines for antityrosinase activity in a cell free system and B16 cells by Ye Y1, Chou GX, Mu DD, Wang H, Chu JH, Leung AK, Fong WF, Yu ZL.(PubMed)

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