Skin aging is one of most visible ageing process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
The degradation of the epidermal and dermal layers of the extracellular matrix (ECM), the non-cellular component present within all tissues and organs, such as UV Exposure, decline of lysosomal/endosomal cathepsin K, S and V activity(c) as well as environment factors such as irregular dryness, dark/light pigmentation, sallowness, severe atrophy, telangiectases, premalignant lesions, laxity, leathery appearance and deep wrinkling, etc., cause modification of the surface of skin and the physical properties of that lead to skin aging. Certain foods have been found to be effective in protect the skin against natural aging, including green tea and garlic.
Lemon is a species of Citrus Aurantifolia, belongs to the family Rutaceae. It has around shape are with green to yellow in color and 3–6 cm in diameter and native to Southeast Asia.
According to University of Catania, Italy, a natural compound isolated from lemon oil (Lem1) not only showed to significantly increase the antioxidative potential of skin biosurface in healthy volunteers but lexhibited a strong antioxidant effects in inhibition of free radical-mediated reactions, as evaluated in vitro and in vivo(32) and may provide a better understanding of the endogenous antioxidant potential of skin and the real validity of a natural antioxidant biotechnology in the antiaging management of the skin(33).
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(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(c) Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis by Sage J1, De Quéral D2, Leblanc-Noblesse E2, Kurfurst R2, Schnebert S2, Perrier E2, Nizard C2, Lalmanach G3, Lecaille F4.(PubMed)
(32) Oxidative stress and antioxidants at skin biosurface: a novel antioxidant from lemon oil capable of inhibiting oxidative damage to the skin by Calabrese V1, Scapagnini G, Randazzo SD, Randazzo G, Catalano C, Geraci G, Morganti P(PubMed)
(33) Biochemical studies on a novel antioxidant from lemon oil and its biotechnological application in cosmetic dermatology by Calabrese V1, Randazzo SD, Catalano C, Rizza V.(PubMed)