Overcome Infertility: Anti-sperm Antibody

Posted by Chantel Martiromo

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Fertility is a natural process to insure the survival of human species. Through natural selection, we produce many offspring when the reproductive system works at it's peak in the suitable environment with plenty of food around. On the other hand, the reproductive system may completely shut down or work at it's minimum state in reproduction of offspring, when the environment is hostile including less foods around, war, epidemic, but regardless of all these factors, most women are capable of conceiving during their menstrual stages before menopause.

Antisperm antibody can be produced by either partner. It is defined as a certain class of protein attaches themselves to the sperm, causing other cells in the immune system to attack them, leading to low quality sperm in men and effecting the ability of sperm to fertilize the egg in women.

1. Causes
Since the protein can attach to the sperm, it inhibits the sperm function in egg fertilization
a) Blood contamination
A Man may produce antisperm antibody, if he injures to his testicle or due to surgery such as undescent testicle surgery, testicle biopsy, testicle torsion, etc.
b) Break down of the test barrier
Normally sperm are kept separate from blood and immune system. If there are damage to the barrier for what ever reason, the immune system may recognize the sperm as the foreign intrusion and destroy them.
c) When it is formed
For what ever reasons, antisperm antibody can be formed due to infection, inflammation or medicine, etc. If it exist, it may interferes with quality of sperm in men and make cervical mucus hostile to sperm invasion, leading to infertility.

2. Treatments
a) Corticosteroids
Corticosteroids is a drug which normally used to treat any swelling condition such as skin problems, severe allergies, asthma, and arthritis. It works effectively in reducing the production of antisperm antibody, but it causes serious side effect including make infections harder to treat, nervousness, restlessness, sleep problems, and indigestion.
b) Sperm treatments that use for ertificila insemination such as rapid washing and freeze-thawing.
conventional medicine plays an important role and most of the time is the first treatment for a couple who for what ever reason cam not conceive after 1 year of unprotected sexual intercourse or can not carry the pregnancy to full term. With the advance of medical technology, conventional medicine has proven record in treating infertility but with some side effects. In this article, we will discuss Laparotomy microsurgery: definition, effects, side effects and risk of conventional medication in treating hormone imbalance.

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