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Fertility is a natural process to insure the survival of human species.
Through natural selection, we produce many offspring when the
reproductive system works at it's peak in the suitable environment with
plenty of food around. On the other hand, the reproductive system may
completely shut down or work at it's minimum state in reproduction of
offspring, when the environment is hostile including less foods around,
war, epidemic, but regardless of all these factors, most women are
capable of conceiving during their menstrual stages before menopause.
system helps to recognize the foreign invasion such as forming of free
radicals, bacteria and virus and destroy them. For some reasons, Some
women and men's immune system become abnormal, leading the immune system
to attach it's own body tissues or view the sperm as foreign invasion.
Types of immune dysfunction effecting infertility
a) Anti-phospholipid antibody syndrome
syndrome is defined as a condition which causes blood clotting in the
arteries or veins and various other problems. It also causes abnormal
production of antibody which attached not only the body invader but also
it' s body tissues including sperm in the test, leading to low quality
As of today, there is still no cure for the above syndrome,
but some convention medication can help to control it, thereby reducing
the risk of blood clotting and infertility.
b) Antinuclear antibody (ANA)
antibodies are as specific class of auto antibodies which have the
ability to attack structures in the nucleus of cells instead of
performing the normal antibody function. Since the nucleus of a cell
contains genetic material referred to as DNA (deoxyribonucleic acid),
ANA (antinuclear antibody) test can be performed on a patient's blood
sample as part of the diagnostic process to detect certain autoimmune
diseases caused by above.
c) Antithyroid antibodies
antibodies can be tested by diagnosing the patient thyroid hormone and
the thyroid stimulating hormone TSH in the blood sample. Only
hypothyroidism causes auto immune dysfunction. They are defined as
abnormal function of antibodies produced by immune system act directly
against the thyroid gland. It may be caused by inflammation of the
thyroid gland leading to abnormal production of certain antithyroid
antibodies such as antithyroglobulin and antimicrosomal that cause
miscarriage by attacking the placental or fetal tissues.
d) Anti-sperm antibody
antibody can be produced by either partner. It is defined as a certain
class of protein attaching themselves to the sperm, causing other cells
in the immune system to attack them, leading to low quality sperm in men
and effecting the ability of sperm to fertilize the egg in women.
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