Overcome Infertility: Immune Dysfunction

Posted by Chantel Martiromo

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Fertility is a natural process to insure the survival of human species. Through natural selection, we produce many offspring when the reproductive system works at it's peak in the suitable environment with plenty of food around. On the other hand, the reproductive system may completely shut down or work at it's minimum state in reproduction of offspring, when the environment is hostile including less foods around, war, epidemic, but regardless of all these factors, most women are capable of conceiving during their menstrual stages before menopause.

Immune system helps to recognize the foreign invasion such as forming of free radicals, bacteria and virus and destroy them. For some reasons, Some women and men's immune system become abnormal, leading the immune system to attach it's own body tissues or view the sperm as foreign invasion.

 Types of immune dysfunction effecting infertility
a) Anti-phospholipid antibody syndrome
Antiphospholipid syndrome is defined as a condition which causes blood clotting in the arteries or veins and various other problems. It also causes abnormal production of antibody which attached not only the body invader but also it' s body tissues including sperm in the test, leading to low quality of sperm.
As of today, there is still no cure for the above syndrome, but some convention medication can help to control it, thereby reducing the risk of blood clotting and infertility.

b) Antinuclear antibody (ANA)
Antinuclear antibodies are as specific class of auto antibodies which have the ability to attack structures in the nucleus of cells instead of performing the normal antibody function. Since the nucleus of a cell contains genetic material referred to as DNA (deoxyribonucleic acid), ANA (antinuclear antibody) test can be performed on a patient's blood sample as part of the diagnostic process to detect certain autoimmune diseases caused by above.

c) Antithyroid antibodies
Antithyroid antibodies can be tested by diagnosing the patient thyroid hormone and the thyroid stimulating hormone TSH in the blood sample. Only hypothyroidism causes auto immune dysfunction. They are defined as abnormal function of antibodies produced by immune system act directly against the thyroid gland. It may be caused by inflammation of the thyroid gland leading to abnormal production of certain antithyroid antibodies such as antithyroglobulin and antimicrosomal that cause miscarriage by attacking the placental or fetal tissues.

d) Anti-sperm antibody
Antisperm antibody can be produced by either partner. It is defined as a certain class of protein attaching themselves to the sperm, causing other cells in the immune system to attack them, leading to low quality sperm in men and effecting the ability of sperm to fertilize the egg in women.

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