Hyperlipidemia or high blood cholesterol is a medical condition characterized by abnormally high levels of lipids in the blood.
Cholesterol produced by the liver plays an essential role in moderate amount in orchestrating the production of steroid hormone and vitamin D, building strong cell walls and aiding the digestive system in absorbing nutrients and fluids.
There are 2 types of blood cholesterol
* The high-density lipoprotein is also known as good cholesterol processes a function to return cholesterol to the liver.
* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in moderate amount.
In a healthy individual, unused cholesterol is returned to the liver. However, overexpression of "bad" cholesterol due to the consumption of a high-fat diet and reduced levels of "good" cholesterol can cause bad cholesterol remaining in the bloodstream, leading to hyperlipidemia.
The healthy ratio of total blood cholesterol ("bad"/ "good") is any numbers that are less than 4.
Patients with hyperlipidemia are assymptomatic. However, over time hyperlipidemia can cause plaque accumulated on the arterial wall, that causes atherosclerosis, a leading cause of heart disease and stroke.
According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL in the US.
Believe it or not, hyperlipidemia, the life-long condition is treatable. By a change of diet and daily moderate exercise, you may control the condition without medication.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential and natural compound for the prevention and treatment hyperlipidemia, researchers examined the antihyperlipidemic and antioxidative potentials of onion (Allium cepa L.) extract fermented with a novel Lactobacillus casei HD-010.
Onion oral administration on ApoE-deficient mice, compared to bezafibrate (10 mg/kg, bw/day) as a positive control, showed a significant reduction of the levels of low-density lipoprotein (LDL), triglyceride (TG), and cholesterol.
Also, compared to the positive control, onion group displayed increased levels of high-density lipoprotein (HDL).
Furthermore, the levels of HMG-CoA reductase associated with the production of good cholesterol was increased by 20% in the fermented onion-treated group at 100 mg/kg.
Moreover, Cholesteryl Ester Transfer Protein (CETP) enzyme associated with moving cholesterol esters and triglycerides between VLDL, LDL, and HDL. LowerCETP levels promote HDL formation was inhibited by injection of onion compared to the control group.
Based on the findings, researchers said, "These results suggest that fermented onion has a preventive/therapeutic effect on the hyperlipidemic disease. It might have potential to be developed as a functional food".
In order to reveal more about the information about onion anti-hyperlipidemic activity, researchers evaluated the effects of raw red onion consumption on metabolic features in overweight and obese women with polycystic ovary syndrome.
The randomized controlled clinical trial, included a total of 54) patients randomly allocated to the intervention group as 'high-onion' (raw red onions: 2 × 40-50 g/day if overweight and 2 × 50-60 g/day if obese) or to the control group as 'low-onion' (raw red onions: 2 × 10-15 g/day) along with limited liliaceous vegetables for 8 weeks.
According to the tested analysis, onion administration significantly decreased the levels of total cholesterol in the high-onion group compared to the low-onion group.
Particularly, levels of low-density lipoprotein cholesterol decreased significantly in the high-onion group, compared to the low-onion group after treatment.
However, levels of triglycerides, high-density lipoprotein cholesterol and lipoprotein did not differ significantly after 8-week onion treatment.
These results strongly suggested that raw red onion consumption is effective in lower cholesterol in women with polycystic ovary syndrome.
Taken altogether, onion may be considered a remedy for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Effects of raw red onion consumption on metabolic features in overweight or obese women with polycystic ovary syndrome: a randomized controlled clinical trial by Ebrahimi-Mamaghani M1, Saghafi-Asl M, Pirouzpanah S, Asghari-Jafarabadi M. (PubMed)
(2)Antihyperlipidemic and Antioxidative Potentials of Onion (Allium cepa L.) Extract Fermented with a Novel Lactobacillus casei HD-010 by Yang WS1,2, Kim JC3, Lee JY4, Kim CH5, Hwang CW6. (PubMed)
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