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Sunday, August 18, 2019

Yoga In Reduced Psychological symptoms in HIV-1 Infected Patients

Yoga may be used as an integrated form of exercise in reduced psychological symptoms of anxiety and patients with Human immunodeficiency virus (HIV) infected individuals, randomized controlled pilot studies suggested.

Yoga, the ancient practical technique for harmonized external and internal body well beings, through breath control, meditation, bodily movement, and gesture..... has been best known for people in the Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

Human immunodeficiency virus (HIV) is a lentivirus with function in induced acquired immunodeficiency syndrome, if not treated.

According to the Yoga Anusandhana Samsthana (SVYASA) University study with an aim to contribute towards the understanding the therapeutic benefits of specific yoga modulation in HIV-1 infected subjects, yoga participated group displayed an indirect effect of HIV-1 induced hematopoietic inhibition of CD34+ progenitor stem cells, a hematopoietic progenitor cells found in bone marrow and cord blood with loss of human hematopoietic precursor cell function, via the CD4+ T lymphocytes in signaling immune response to destroy the infectious particle.

In other words, yoga practice normalized the inhibition of replication and enhancement of levels of hematopoiesis in HIV-1 infected subjects, through infected of CD34+ progenitor stem cells by activated immune action.

The hematopoietic stem cell has long been hypothesized to be a target of human immunodeficiency virus type-1 (HIV) infection.

Additionally, Yoga participant also showed to improve the self renewal capacity of numbers of cycles of cell division while maintaining the undifferentiated state to differentiate into CD34+ progenitor cells, through STAT5 gene in activated hematopoietic cytokines in modulates cytokine responses, including interleukin-2 and 15, transforming growth factor-β (TGF-β) and tumor necrosis factor-α (TNF-α) in development of Tregs in immune regulation.

CD34+, undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells.

Transforming growth factor-β (TGF-β) is a secreted protein in the regulated cellular process including the control of cell growth, cell proliferation, cell differentiation, and apoptosis.

Tumor necrosis factor-alpha, TNFα, cachexin, or cachectin) is a cell-signaling cytokine involved in systemic inflammation in the acute phase infection.

Interleukin-2 and 15 are cell-signaling proteins in the immune system in regulated the activities of white blood cells of the immunity.

More interesting, in psychological aspects, yoga induced hematopoietic inhibition in HIV-1 infection was contributed by the role of reduced stress involved sycho-neuroimmunological axis (PNI), the interaction between psychological processes and the nervous and immune systems of the human body in the induction of psychological symptoms, such as anxiety and depression and quality of life

In deed, physical postures (asanas), breathing practices (pranayama), relaxation techniques, and meditation have shown to bring back consciousness in the present moment and increased the ability to maintain or positive feelings to minimize or regulate stress feelings or letting them go, thus decreasing stress effect in suppressed body's immune system and neuro-humoral actions in transmitting information from cells to cells, thereby affecting normal psychological state.

Additionally, researchers at the study also said, "Yoga therapy is introduced and its effectiveness in terms of evidence in the relevant area is reviewed. Further, the basic principles of Integrated Approach of Yoga Therapy [IAYT] are described and depending on the potential mechanisms through which yoga therapy may act, both modern scientific research and ancient "scriptural" evidence are provided at all the five levels of existence (body, life force, emotional, intellectual and bliss)" and "This will enable to design comprehensive yoga modules that may intervene in this indirect inhibition of hematopoiesis in HIV-1 infected individuals and potentially restore normal levels of hematopoiesis".

Furthermore, in a study of 44 HIV-1 infected individuals from two HIV rehabilitation centers of Manipur State of India randomized into two groups: Yoga (n = 22; 12 males) group received IY intervention, which included physical postures (asanas), breathing practices (pranayama), relaxation techniques, and meditation, given 60 min/day, 6 days a week for 1 month and Control group (n = 22; 14 males), followed daily routine during this period, researchers found that yoga group showed a significant reduction in depression scores along with non significant increment in CD4 counts in surface of the immune cells but non-significant reduction in anxiety scores in compared to the control group.

An at the end of the experiment, researchers concluded that short term yoga participated may have a positive effect in reduced depression and improved immunity in HIV-1 infected adults.

Taking all together, Yoga intervention as an adjunct therapy may have a profound effect in reduced psychological symptoms and treatment of inhibited hematopoiesis in HIV-1 infected individuals by regulating the immune function in restore normal function of hematologists in production of blood cells and platelets.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Effect of Integrated Yoga (IY) on psychological states and CD4 counts of HIV-1infected patients: A randomized controlled pilot study by Naoroibam R1, Metri KG1, Bhargav H1, Nagaratna R2, Nagendra HR1(PubMed)
(2) Potential yoga modules for treatment of hematopoietic inhibition in HIV-1 infection by Bhargav H1, Raghuram N, Rao NH, Tekur P, Koka PS.(PubMed)

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