Pruritus is a skin condition associated with severe itching of the affected area, particularly in people with dry skin.
The syndrome has been found mostly in older adults due to aging-induced dehydration of the surface of the skin.
Most common symptoms of the affect areas are redness, bumps, spots or blisters, cracked skin leathery or scaly skin due to scratching.
Most common causes of pruritus are associated with the immune system overreaction of the allergens, infection and other medical conditions, leading to the skin inflammation-induced itching.
Therefore by finding out the cause of the condition, pruritus can be treated successfully.
Some researchers suggested that people with psychological problems such as depression, anxiety or obsessive-compulsive disorder may also trigger the onset of skin itching.
Dr. Hong Liang Tey, the lead scientist in the analysis of the correlation between psychosomatic factors in pruritus said, "Pruritus and psyche are intricately and reciprocally related, with psychophysiological evidence and psychopathological explanations helping us to understand their complex association".
And, "Their interaction may be conceptualized and classified into 3 groups: pruritic diseases with psychiatric sequelae, pruritic diseases aggravated by psychosocial factors, and psychiatric disorders causing pruritus".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential ingredient for the treatment of pruritus, researchers examined the anti-allergic effect of Curcuma aromatic's constituents curcumin, demethoxycurcumin, and bisdemethoxycurcumin.
In subjects included pruritus by compound 48/80, curcuminoids inhibited the passive cutaneous anaphylaxis (PCA) reaction induced by the IgE-antigen complex (IAC) and the scratching behavior.
Where passive cutaneous anaphylaxis (PCA) is an animal model for Type I allergy.
Furthermore, curcumin, demethoxycurcumin, and bisdemethoxycurcumin. also inhibited proteins associated with the production of pro-inflammatory cytokines and IgE-antigen complex (IAC) induced RBL-2H3 cells.
Additional analysis of the efficacy of curcuminoids, researchers found that curcumin is the most potent compound followed by demethoxycurcumin and bisdemethoxycurcumin.
Based on the findings, researchers said, "curcuminoids, particularly curcumin, can improve the symptoms of allergic diseases, such as anaphylaxis and itching".
Moreover, scientists in the evaluation of an ethanol extract of turmeric ("Curcuma longa") and an ointment of curcumin (its active ingredient) in symptomatic relief in patients with external cancerous lesions found that the application reduced the smell in 90% of the cases and itching in almost all cases.
Both ethanol extract of turmeric and ointment of curcumin also inhibited dry lesions in 70% of the cases, and reduced lesion size and pain in 10% of patients.
Taken altogether, turmeric processed a high number of curcuminoids may be considered supplements for the treatment of pruritus, , pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Inhibitory effects of curcuminoids on passive cutaneous anaphylaxis reaction and scratching behavior in mice by Trinh HT1, Bae EA, Lee JJ, Kim DH. (PubMed)
(2) Turmeric and curcumin as topical agents in cancer therapy by Kuttan R, Sudheeran PC, Josph CD. (PubMed)
(3) Psychosomatic factors in pruritus by Hong Liang Tey, MD, Joanna Wallengren, MD and Gil Yosipovitch, MD. (PMC)
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