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Tuesday, January 21, 2014

Antioxidant Melatonin and Non alcoholic fatty liver disease

Melatonin supplement, a synthetic product of the vertebrate pineal gland was sfound to have significantly broader actions including oncostatic effects (Blask et al., 2002), immunesystem stimulation (Guerrero & Reiter, 2002)and anti-inflammatory functions.
Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.  

The benefits
In the study to investigate melatonin's preventive action in oxidative stress in a rat model with high fat diet-induced non-alcoholic fatty liver disease (NAFLD)in in adult, male, Wistar rats, Melatonin was ineffective in reverse the abnormal action of lipid accumulation and in enhancing normal lipidemic serum markers, but it enhanced the antioxidant effects by protecting the liver against the peroxidation and oxidative stress in liver tissue as well as a significant increasing of glutathione.

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The side effects of Melatonin may include nightmares, nausea, abdominal issues, an altered sleep pattern, etc.

(1) Melatonin as an antioxidant: biochemical mechanisms andpathophysiological implications in humans (Acta, Biochimica, Polonica)
(2) Melatonin attenuates high fat diet-induced fatty liver disease in rats by Hatzis G, Ziakas P, Kavantzas N, Triantafyllou A, Sigalas P, Andreadou I, Ioannidis K, Chatzis S, Filis K, Papalampros A, Sigala F.(PubMed)

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