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Wednesday, January 22, 2014

Triterpenoid and Non alcoholic liver disease

Triterpenoid is a various unsaturated hydrocarbons, found in essential oils and oleoresins of plants, including Ilex hainanensis Merr.

Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.  

Progression of nonalcoholic steatohepatitis (NASH) to Non alcoholic liver disease is inevitable if left untreated. Ilex hainanensis Merr. is the Chinese herb used to treat for hypertension, dyslipidemia and inflammation in Traditional Chinese Medicine (TCMs) and may be a potential medicine to treat Non alcoholic fatty disease. In the study to test the effect of Triterpenoid-rich fraction (TP) from Ilex hainanensis Merr. on NAFLD with Male Sprague-Dawley (SD) rats fed a normal diet (control) or high fat diet (NAFLD model), after 4 weeks, the high fat diet group was orally administrated TF (250 mg/kg) for another two weeks. TP not only improves the symptoms of the subjects, but also decreases the levels of triglyceride , total cholesterol, low-density lipoprotein cholesterol, abnormality of lipid accumulation , levels of inflammation and infection and apoptosis response in the liver. Of these results, TF is found to be effective in protecting liver against NAFLD by regulating lipids metabolism and alleviating insulin resistance, inflammation and oxidative stress.

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Reference
(1) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga, 1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(2) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)

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